SU458976A3 - Способ получени -(транс-4оксициклогексил-2-амино-3,5дибромбензил)-амина - Google Patents
Способ получени -(транс-4оксициклогексил-2-амино-3,5дибромбензил)-аминаInfo
- Publication number
- SU458976A3 SU458976A3 SU1911298A SU1911298A SU458976A3 SU 458976 A3 SU458976 A3 SU 458976A3 SU 1911298 A SU1911298 A SU 1911298A SU 1911298 A SU1911298 A SU 1911298A SU 458976 A3 SU458976 A3 SU 458976A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- trans
- amino
- dibromobenzyl
- amine
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- -1 trans-4-hydroxycyclohexyl-2-amino-3, 5-dibromobenzyl Chemical group 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000012280 lithium aluminium hydride Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PACIGGABLPTEDO-XYPYZODXSA-N NC1=C(C=N[C@@H]2CC[C@H](CC2)O)C=C(C=C1Br)Br Chemical compound NC1=C(C=N[C@@H]2CC[C@H](CC2)O)C=C(C=C1Br)Br PACIGGABLPTEDO-XYPYZODXSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722218647 DE2218647A1 (de) | 1972-04-18 | 1972-04-18 | Neues verfahren zur herstellung von n-(trans-4-hydroxy-cyclohexyl)-(2-amino3,5-dibrom-benzyl)-amin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU458976A3 true SU458976A3 (ru) | 1975-01-30 |
Family
ID=5842287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1911298A SU458976A3 (ru) | 1972-04-18 | 1973-04-16 | Способ получени -(транс-4оксициклогексил-2-амино-3,5дибромбензил)-амина |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS554096B2 (cg-RX-API-DMAC7.html) |
| AT (1) | AT321270B (cg-RX-API-DMAC7.html) |
| BG (1) | BG22807A3 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1003441A (cg-RX-API-DMAC7.html) |
| CH (1) | CH575907A5 (cg-RX-API-DMAC7.html) |
| CS (1) | CS174876B2 (cg-RX-API-DMAC7.html) |
| DD (1) | DD107261A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2218647A1 (cg-RX-API-DMAC7.html) |
| DK (2) | DK139515C (cg-RX-API-DMAC7.html) |
| ES (2) | ES413827A1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI56522C (cg-RX-API-DMAC7.html) |
| HU (1) | HU165758B (cg-RX-API-DMAC7.html) |
| NO (1) | NO137086C (cg-RX-API-DMAC7.html) |
| PL (1) | PL86344B1 (cg-RX-API-DMAC7.html) |
| RO (1) | RO65104A (cg-RX-API-DMAC7.html) |
| SE (2) | SE415970B (cg-RX-API-DMAC7.html) |
| SU (1) | SU458976A3 (cg-RX-API-DMAC7.html) |
| YU (1) | YU35573B (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2223193C3 (de) * | 1972-05-12 | 1975-05-28 | Dr. Karl Thomae Gmbh, 7950 Biberach | Verfahren zur Herstellung von 2-Amino-benzylaminen |
| US4020104A (en) * | 1976-09-20 | 1977-04-26 | The Upjohn Company | Process for isomerizing cis,cis- and cis,trans-isomers of di-(p-aminocyclohexyl)methane to the corresponding trans,trans-isomer |
| DE2720867C2 (de) * | 1977-05-10 | 1979-05-31 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Verfahren zur quantitativen Abtrennung von Uran aus Proben natürlichen Wassers |
| DE3366070D1 (en) * | 1983-06-29 | 1986-10-16 | Heumann Ludwig & Co Gmbh | Process for the preparation of 2-amino-3,5-dibromobenzyl amines |
| IT1216837B (it) * | 1987-01-07 | 1990-03-14 | Erregierre Ind Chim | Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica. |
| HU207834B (en) * | 1989-12-22 | 1993-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing n-/2-amino-3,5-dibromo-benzyl/-trans-4-amino-cyclohexanol |
-
1972
- 1972-04-18 DE DE19722218647 patent/DE2218647A1/de active Pending
-
1973
- 1973-03-14 RO RO7416173A patent/RO65104A/ro unknown
- 1973-03-22 DD DD16964973A patent/DD107261A5/xx unknown
- 1973-04-06 AT AT302573A patent/AT321270B/de not_active IP Right Cessation
- 1973-04-13 CS CS264873A patent/CS174876B2/cs unknown
- 1973-04-13 CH CH537473A patent/CH575907A5/xx not_active IP Right Cessation
- 1973-04-16 JP JP4298973A patent/JPS554096B2/ja not_active Expired
- 1973-04-16 BG BG023331A patent/BG22807A3/xx unknown
- 1973-04-16 HU HUTO000903 patent/HU165758B/hu unknown
- 1973-04-16 YU YU101773A patent/YU35573B/xx unknown
- 1973-04-16 SU SU1911298A patent/SU458976A3/ru active
- 1973-04-17 NO NO162073A patent/NO137086C/no unknown
- 1973-04-17 FI FI123273A patent/FI56522C/fi active
- 1973-04-17 CA CA168,938A patent/CA1003441A/en not_active Expired
- 1973-04-17 SE SE7305489A patent/SE415970B/sv unknown
- 1973-04-17 ES ES413827A patent/ES413827A1/es not_active Expired
- 1973-04-17 PL PL16196373A patent/PL86344B1/pl unknown
- 1973-04-17 DK DK212473A patent/DK139515C/da not_active IP Right Cessation
- 1973-12-04 ES ES421120A patent/ES421120A1/es not_active Expired
-
1975
- 1975-12-08 SE SE7513808A patent/SE421613B/xx not_active IP Right Cessation
-
1976
- 1976-12-17 DK DK570776A patent/DK570776A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE415970B (sv) | 1980-11-17 |
| DK139515B (da) | 1979-03-05 |
| HU165758B (cg-RX-API-DMAC7.html) | 1974-10-28 |
| DE2218647A1 (de) | 1973-10-25 |
| ES413827A1 (es) | 1976-01-16 |
| CA1003441A (en) | 1977-01-11 |
| SE421613B (sv) | 1982-01-18 |
| BG22807A3 (bg) | 1977-04-20 |
| CH575907A5 (cg-RX-API-DMAC7.html) | 1976-05-31 |
| NO137086B (no) | 1977-09-19 |
| JPS554096B2 (cg-RX-API-DMAC7.html) | 1980-01-29 |
| YU101773A (en) | 1980-10-31 |
| YU35573B (en) | 1981-04-30 |
| FI56522B (fi) | 1979-10-31 |
| AT321270B (de) | 1975-03-25 |
| NO137086C (no) | 1977-12-28 |
| DK139515C (da) | 1979-08-20 |
| DK570776A (da) | 1976-12-17 |
| RO65104A (fr) | 1979-08-15 |
| CS174876B2 (cg-RX-API-DMAC7.html) | 1977-04-29 |
| ES421120A1 (es) | 1976-06-16 |
| PL86344B1 (cg-RX-API-DMAC7.html) | 1976-05-31 |
| FI56522C (fi) | 1980-02-11 |
| SE7513808L (sv) | 1975-12-08 |
| DD107261A5 (cg-RX-API-DMAC7.html) | 1974-07-20 |
| JPS4914443A (cg-RX-API-DMAC7.html) | 1974-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU662005A3 (ru) | Способ получени замещенных бензамидов или их солей | |
| US2841584A (en) | Hexahydropyridazine, derivatives thereof, and process | |
| SU458976A3 (ru) | Способ получени -(транс-4оксициклогексил-2-амино-3,5дибромбензил)-амина | |
| US2626263A (en) | Hydantoin derivative | |
| SU541434A3 (ru) | "Способ получени производных изотиазола или их солей | |
| US3714241A (en) | PREPARATION OF alpha -METHYL-3,4-DISUBSTITUTED PHENYLALANINES | |
| US2519530A (en) | Biotin aliphatic amides and method for their preparation | |
| US2906772A (en) | Resolution of di-2, 2-diphenyl-3-methyl-4-dimethylaminobutyronitrile | |
| SU550976A3 (ru) | Способ получени 3-фтор- -ананина | |
| US2741614A (en) | N-isobutylnormorpfflne compounds | |
| US3553197A (en) | 3-(3',4'-disubstituted phenyl)-2-methyl-aziridine-2- carboxylic acid or esters | |
| US2970159A (en) | Hydrazine derivatives | |
| US2492373A (en) | Imidazolone preparation | |
| SU503523A3 (ru) | Способ получени -(гетероарилметил)- -дезокси-нормофинов или -норкодеинов | |
| SU426366A3 (ru) | Способ получения производных1-арил-2,3,4,5 тетрагидро-1 н-1,5-бензодиазепин-2-она | |
| US2846469A (en) | Method of preparing synthetic dl-3 monoamide of 1-aminoglutaric acid (dl-glutamine) | |
| Erhardt et al. | Facile Formation of Quaternary Azetidinium Compounds During Triflation of Dialkylaminopropanols | |
| SU455097A1 (ru) | Способ получени хлористоводородных солей амидов -аминопинановой кислоты | |
| GB2184726A (en) | Azoniaspironortropanol esters, processes for the preparation thereof and pharmaceutical compositions containing them | |
| SU501668A3 (ru) | Способ получени производных 2-аминобензиламина | |
| Garratt et al. | The Reaction of Diketene with Glycine | |
| Schaefgen et al. | Synthesis of an Octabasic Carboxylic Acid | |
| US4113948A (en) | 1-amino-1-phthalidyl alkanes and a method for producing same | |
| SU851930A1 (ru) | Способ получени 5-диаминотетразола | |
| SU422136A3 (ru) | Способ получения пентациклических соединений |