IT1216837B - Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica. - Google Patents

Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica.

Info

Publication number
IT1216837B
IT1216837B IT8719008A IT1900887A IT1216837B IT 1216837 B IT1216837 B IT 1216837B IT 8719008 A IT8719008 A IT 8719008A IT 1900887 A IT1900887 A IT 1900887A IT 1216837 B IT1216837 B IT 1216837B
Authority
IT
Italy
Prior art keywords
idrossi
cicloesil
benzylamine
dibromo
trans
Prior art date
Application number
IT8719008A
Other languages
English (en)
Other versions
IT8719008A0 (it
Inventor
Egidio Molinari
Original Assignee
Erregierre Ind Chim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre Ind Chim filed Critical Erregierre Ind Chim
Priority to IT8719008A priority Critical patent/IT1216837B/it
Publication of IT8719008A0 publication Critical patent/IT8719008A0/it
Priority to EP87118941A priority patent/EP0274106A3/en
Priority to US07/137,348 priority patent/US4845114A/en
Priority to JP63000782A priority patent/JPS63198653A/ja
Application granted granted Critical
Publication of IT1216837B publication Critical patent/IT1216837B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT8719008A 1987-01-07 1987-01-07 Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica. IT1216837B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT8719008A IT1216837B (it) 1987-01-07 1987-01-07 Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica.
EP87118941A EP0274106A3 (en) 1987-01-07 1987-12-21 N-(trans-p-hydroxy-cyclohexyl)-(2-amino-3,5-dibromo)benzylamine salts possessing mucolytic activity
US07/137,348 US4845114A (en) 1987-01-07 1987-12-23 N-(trans-p-hydroxy-cyclohexyl)-(2-amino-3,5-dibromo)benzylamine salts possessing mucolytic activity
JP63000782A JPS63198653A (ja) 1987-01-07 1988-01-07 ムコリチック活性をもつＮ−（トランス−ｐ−ビドロキシ−シクロヘキシル）−（２−アミノ−３，５−ジブロモ）ベンジルアミン塩及びその製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8719008A IT1216837B (it) 1987-01-07 1987-01-07 Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica.

Publications (2)

Publication Number Publication Date
IT8719008A0 IT8719008A0 (it) 1987-01-07
IT1216837B true IT1216837B (it) 1990-03-14

Family

ID=11153808

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8719008A IT1216837B (it) 1987-01-07 1987-01-07 Sali della n-(trans-p-idrossi-cicloesil)-(2ammino-3,5-dibromo) benzilammina dotati di attivita' mucolitica.

Country Status (4)

Country Link
US (1) US4845114A (it)
EP (1) EP0274106A3 (it)
JP (1) JPS63198653A (it)
IT (1) IT1216837B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1303065C (zh) * 2004-05-20 2007-03-07 江苏豪森药业股份有限公司 氨溴索半胱氨酸类似物盐及其制备方法和用途
CN112745251B (zh) * 2019-10-31 2023-10-27 华创合成制药股份有限公司 一种治疗祛痰化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218647A1 (de) * 1972-04-18 1973-10-25 Thomae Gmbh Dr K Neues verfahren zur herstellung von n-(trans-4-hydroxy-cyclohexyl)-(2-amino3,5-dibrom-benzyl)-amin
IT1165457B (it) * 1983-07-06 1987-04-22 Poli Ind Chimica Spa Teofillin-7-acetato di ambroxolo

Also Published As

Publication number Publication date
JPS63198653A (ja) 1988-08-17
EP0274106A3 (en) 1989-11-08
EP0274106A2 (en) 1988-07-13
IT8719008A0 (it) 1987-01-07
US4845114A (en) 1989-07-04

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