SU1313348A3 - Способ получени производных эрголина - Google Patents

Способ получени производных эрголина Download PDF

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Publication number
SU1313348A3
SU1313348A3 SU823519900A SU3519900A SU1313348A3 SU 1313348 A3 SU1313348 A3 SU 1313348A3 SU 823519900 A SU823519900 A SU 823519900A SU 3519900 A SU3519900 A SU 3519900A SU 1313348 A3 SU1313348 A3 SU 1313348A3
Authority
SU
USSR - Soviet Union
Prior art keywords
sub
central
theory
methyl
receptors
Prior art date
Application number
SU823519900A
Other languages
English (en)
Russian (ru)
Inventor
Хаффер Грегор
Зауер Герхард
Вахтель Хельмут
Шнайдер Херберт
Эдер Ульрих
Лоренц Ханс-Петер
Original Assignee
Шеринг Аг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Аг (Фирма) filed Critical Шеринг Аг (Фирма)
Application granted granted Critical
Publication of SU1313348A3 publication Critical patent/SU1313348A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SU823519900A 1981-12-23 1982-12-09 Способ получени производных эрголина SU1313348A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813151912 DE3151912A1 (de) 1981-12-23 1981-12-23 Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
SU1313348A3 true SU1313348A3 (ru) 1987-05-23

Family

ID=6150011

Family Applications (1)

Application Number Title Priority Date Filing Date
SU823519900A SU1313348A3 (ru) 1981-12-23 1982-12-09 Способ получени производных эрголина

Country Status (18)

Country Link
US (1) US4826852A (enExample)
EP (2) EP0185392A3 (enExample)
JP (1) JPS58150593A (enExample)
AT (1) ATE27458T1 (enExample)
AU (1) AU570621B2 (enExample)
CA (1) CA1319684C (enExample)
CS (1) CS235098B2 (enExample)
DD (1) DD208619A5 (enExample)
DE (2) DE3151912A1 (enExample)
DK (1) DK163240C (enExample)
ES (1) ES8400115A1 (enExample)
GR (1) GR78410B (enExample)
HU (1) HU191623B (enExample)
IE (1) IE56541B1 (enExample)
IL (1) IL67545A (enExample)
RO (2) RO85270B (enExample)
SU (1) SU1313348A3 (enExample)
YU (1) YU282382A (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8400333A (nl) * 1983-02-16 1984-09-17 Sandoz Ag Moederkoornalkaloiden, hun bereiding en hun toepassing.
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
NL8503426A (nl) * 1984-12-24 1986-07-16 Sandoz Ag 8alfa-acylamino-ergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
DE3528584A1 (de) * 1985-08-06 1987-02-19 Schering Ag Neue 1-alkyl-ergolin-thioharnstoffderivate
DE3528576A1 (de) * 1985-08-06 1987-02-19 Schering Ag Verfahren zur herstellung von ergolin-thioharnstoffen
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
HU196598B (en) * 1986-04-25 1988-12-28 Richter Gedeon Vegyeszet Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
DE3915950A1 (de) * 1989-05-12 1990-11-15 Schering Ag 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
US5229129A (en) * 1989-07-12 1993-07-20 Cygnus Therapeutic Systems Transdermal administration of lisuride
US5252335A (en) * 1989-07-12 1993-10-12 Cygnus Therapeutic Systems Transdermal administration of lisuride
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
US20060140820A1 (en) 2004-12-28 2006-06-29 Udo Mattern Use of a container of an inorganic additive containing plastic material
RU2480208C2 (ru) 2006-10-04 2013-04-27 М Унд П Патент Акциенгезелльшафт Система доставки с контролируемым высвобождением для назального применения нейротрансмиттеров
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
AR086400A1 (es) 2011-05-13 2013-12-11 Trimel Pharmaceuticals Corp Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533698A (en) * 1950-12-12 Urethanes containing the lysergic
US2864822A (en) * 1956-10-22 1958-12-16 Lilly Co Eli 9-amino-7-methyl-belta10-ergolene and derivatives thereof
DE1212097B (de) * 1962-09-05 1966-03-10 Sdruzeni Podnikuu Pro Zdravotn Verfahren zur Herstellung von N-[D-1, 6-Dimethylisoergolenyl-(8)]-N', N'-dialkylharnstoffen
FR1339406A (fr) * 1962-11-23 1963-10-04 Farmaceutici Italia Procédé de préparation de nouveaux dérivés de 6-méthylergoline pi et de 1, 6-diméthylergoline pi
BR6915443D0 (pt) * 1969-07-18 1973-03-13 Farmaceutici Italia Processo para a preparacao de derivados de ergolina
CH573936A5 (enExample) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
GB1573621A (en) * 1976-01-02 1980-08-28 Sandoz Ltd Acylated 6-methyl-8a-amino-ergoline i compounds
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
US3922347A (en) * 1974-12-19 1975-11-25 Lilly Co Eli Method of inhibiting prolactin secretion with 8-acylaminoergolenes
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3063869D1 (en) * 1979-06-13 1983-07-28 Schering Ag (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them
DE3127845A1 (de) * 1980-07-25 1982-04-22 Sandoz-Patent-GmbH, 7850 Lörrach Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen und ihre anwendung bei der therapeutischen behandlung
DE3135305C2 (de) * 1981-09-03 1983-07-21 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen
GB2112382B (en) * 1981-11-06 1985-03-06 Erba Farmitalia Ergoline derivatives
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Патент Швейцарии 605938, кл. С 07 D 57/12, опублик.1978. Патент Швейцарии № 573937, кл. С 07 D 457/12, опублик. 1976. Патент DE № 2924102, кл. С 07 О 457/12, опублик. 1980. *

Also Published As

Publication number Publication date
DE3276433D1 (en) 1987-07-02
YU282382A (en) 1986-12-31
RO87945A (ro) 1986-09-30
CS235098B2 (en) 1985-04-16
ATE27458T1 (de) 1987-06-15
DK566982A (da) 1983-06-24
IL67545A (en) 1986-09-30
IE823051L (en) 1983-06-23
ES518482A0 (es) 1983-11-01
EP0185392A3 (en) 1987-05-13
DE3151912A1 (de) 1983-06-30
US4826852A (en) 1989-05-02
DK163240B (da) 1992-02-10
IL67545A0 (en) 1983-05-15
AU570621B2 (en) 1988-03-24
IE56541B1 (en) 1991-08-28
EP0082808A1 (en) 1983-06-29
JPS58150593A (ja) 1983-09-07
CA1319684C (en) 1993-06-29
GR78410B (enExample) 1984-09-27
EP0082808B1 (en) 1987-05-27
ES8400115A1 (es) 1983-11-01
DK163240C (da) 1992-06-29
CS955382A2 (en) 1984-02-13
EP0185392A2 (en) 1986-06-25
RO85270B (ro) 1984-10-30
JPH0352463B2 (enExample) 1991-08-12
DD208619A5 (de) 1984-04-04
HU191623B (en) 1987-03-30
RO85270A (ro) 1984-09-29
AU9146882A (en) 1983-06-30

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