SMT201600083B - Nuove forme e sali di un inibitore di diidropirrolo[1,2-c]imidazolil aldosterone sintasi o aromatasi - Google Patents
Nuove forme e sali di un inibitore di diidropirrolo[1,2-c]imidazolil aldosterone sintasi o aromatasiInfo
- Publication number
- SMT201600083B SMT201600083B SM201600083T SM201600083T SMT201600083B SM T201600083 B SMT201600083 B SM T201600083B SM 201600083 T SM201600083 T SM 201600083T SM 201600083 T SM201600083 T SM 201600083T SM T201600083 B SMT201600083 B SM T201600083B
- Authority
- SM
- San Marino
- Prior art keywords
- synthasis
- diidropirrol
- aromatasis
- aldosterone
- imidazolyl
- Prior art date
Links
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 title 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 title 1
- -1 IMIDAZOLYL Chemical class 0.000 title 1
- 229960002478 aldosterone Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587280P | 2012-01-17 | 2012-01-17 | |
| PCT/US2013/021521 WO2013109514A1 (en) | 2012-01-17 | 2013-01-15 | New forms and salts of a dihydropyrrolo[1,2-c]imidazolyl aldosterone synthase or aromatase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600083B true SMT201600083B (it) | 2016-04-29 |
Family
ID=47604250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600083T SMT201600083B (it) | 2012-01-17 | 2016-03-23 | Nuove forme e sali di un inibitore di diidropirrolo[1,2-c]imidazolil aldosterone sintasi o aromatasi |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US9334276B2 (pl) |
| EP (1) | EP2804863B1 (pl) |
| JP (1) | JP5749410B2 (pl) |
| KR (2) | KR20140093726A (pl) |
| CN (1) | CN104039793B (pl) |
| AP (1) | AP2014007762A0 (pl) |
| AR (1) | AR089728A1 (pl) |
| AU (1) | AU2013209952B2 (pl) |
| BR (1) | BR112014017260A8 (pl) |
| CA (1) | CA2863339C (pl) |
| CL (1) | CL2014001863A1 (pl) |
| CO (1) | CO7000775A2 (pl) |
| CR (1) | CR20140345A (pl) |
| CU (1) | CU20140086A7 (pl) |
| CY (1) | CY1117914T1 (pl) |
| DK (1) | DK2804863T3 (pl) |
| EA (1) | EA026232B1 (pl) |
| ES (1) | ES2564143T3 (pl) |
| GT (1) | GT201400155A (pl) |
| HR (1) | HRP20160178T1 (pl) |
| HU (1) | HUE026984T2 (pl) |
| IL (1) | IL233541B (pl) |
| IN (1) | IN2014DN06781A (pl) |
| JO (1) | JO3137B1 (pl) |
| MA (1) | MA35858B1 (pl) |
| MX (1) | MX2014008686A (pl) |
| NZ (1) | NZ626277A (pl) |
| PE (1) | PE20142358A1 (pl) |
| PH (1) | PH12014501638A1 (pl) |
| PL (1) | PL2804863T3 (pl) |
| RS (1) | RS54589B1 (pl) |
| SG (1) | SG11201404061YA (pl) |
| SI (1) | SI2804863T1 (pl) |
| SM (1) | SMT201600083B (pl) |
| TN (1) | TN2014000256A1 (pl) |
| TW (1) | TWI609869B (pl) |
| UA (1) | UA114803C2 (pl) |
| UY (1) | UY34576A (pl) |
| WO (1) | WO2013109514A1 (pl) |
| ZA (1) | ZA201404314B (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA33904B1 (fr) * | 2010-01-14 | 2013-01-02 | Novartis Ag | Utilisation d'un agent de modification d'hormones surrénaliennes |
| EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
| TWI707682B (zh) | 2014-07-07 | 2020-10-21 | 瑞士商瑞科戴迪股份有限公司 | 醫藥劑型 |
| AU2016210899B2 (en) | 2015-01-29 | 2019-03-07 | Recordati Ag | Process for the production of condensed imidazolo Derivatives |
| WO2016164476A2 (en) * | 2015-04-06 | 2016-10-13 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
| JP7130636B2 (ja) * | 2016-10-27 | 2022-09-05 | ダミアン ファーマ アーゲー | アルドステロンシンターゼ阻害剤 |
| WO2018078049A1 (en) * | 2016-10-27 | 2018-05-03 | Damian Pharma Ag | Aldosterone synthase inhibitor |
| SG11202010906XA (en) | 2018-05-03 | 2020-12-30 | Damian Pharma Ag | R-fadrozole for use in the treatment of aldostonerism |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1315449A (en) * | 1918-11-15 | 1919-09-09 | Frank B Yingling | Shaper-feed. |
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5066656A (en) | 1989-11-01 | 1991-11-19 | Janssen Pharmaceutica N.V. | Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives |
| MTP1076B (en) | 1990-01-12 | 1991-09-30 | Ciba Geigy Ag | Hemihydrate |
| JPH07503242A (ja) | 1992-01-27 | 1995-04-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アロマターゼ阻害剤としてのピロロイミダゾリルおよびイミダゾピリジニル置換１ｈ−ベンズイミダゾール誘導体 |
| PT1565463E (pt) * | 2002-11-18 | 2008-09-10 | Novartis Ag | Derivados de imidazo[1,5-a]piridina e métodos para tratar doenças mediadas pela aldosterona |
| GT200600381A (es) * | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| MX2009006481A (es) | 2006-12-18 | 2009-06-26 | Novartis Ag | Derivados de imidazol 1-sustituidos, y su uso como inhibidores de la sintasa de aldosterona. |
| CN102666535B (zh) | 2009-11-30 | 2015-02-25 | 诺华股份有限公司 | 作为醛固酮合酶抑制剂的咪唑衍生物 |
| MA33904B1 (fr) * | 2010-01-14 | 2013-01-02 | Novartis Ag | Utilisation d'un agent de modification d'hormones surrénaliennes |
-
2013
- 2013-01-15 PL PL13701194T patent/PL2804863T3/pl unknown
- 2013-01-15 AU AU2013209952A patent/AU2013209952B2/en active Active
- 2013-01-15 NZ NZ626277A patent/NZ626277A/en not_active IP Right Cessation
- 2013-01-15 DK DK13701194.6T patent/DK2804863T3/en active
- 2013-01-15 WO PCT/US2013/021521 patent/WO2013109514A1/en not_active Ceased
- 2013-01-15 TW TW102101537A patent/TWI609869B/zh not_active IP Right Cessation
- 2013-01-15 MX MX2014008686A patent/MX2014008686A/es unknown
- 2013-01-15 SG SG11201404061YA patent/SG11201404061YA/en unknown
- 2013-01-15 JP JP2014552375A patent/JP5749410B2/ja active Active
- 2013-01-15 HR HRP20160178T patent/HRP20160178T1/hr unknown
- 2013-01-15 KR KR1020147016954A patent/KR20140093726A/ko not_active Ceased
- 2013-01-15 EA EA201491374A patent/EA026232B1/ru not_active IP Right Cessation
- 2013-01-15 US US14/370,124 patent/US9334276B2/en active Active
- 2013-01-15 UA UAA201406492A patent/UA114803C2/uk unknown
- 2013-01-15 AP AP2014007762A patent/AP2014007762A0/xx unknown
- 2013-01-15 SI SI201330142A patent/SI2804863T1/sl unknown
- 2013-01-15 KR KR20147030158A patent/KR20140141687A/ko not_active Ceased
- 2013-01-15 CA CA2863339A patent/CA2863339C/en active Active
- 2013-01-15 JO JOP/2013/0014A patent/JO3137B1/ar active
- 2013-01-15 IN IN6781DEN2014 patent/IN2014DN06781A/en unknown
- 2013-01-15 ES ES13701194.6T patent/ES2564143T3/es active Active
- 2013-01-15 HU HUE13701194A patent/HUE026984T2/en unknown
- 2013-01-15 CN CN201380005054.0A patent/CN104039793B/zh active Active
- 2013-01-15 PE PE2014001112A patent/PE20142358A1/es not_active Application Discontinuation
- 2013-01-15 RS RS20160109A patent/RS54589B1/sr unknown
- 2013-01-15 AR ARP130100119A patent/AR089728A1/es unknown
- 2013-01-15 BR BR112014017260A patent/BR112014017260A8/pt not_active Application Discontinuation
- 2013-01-15 EP EP13701194.6A patent/EP2804863B1/en active Active
- 2013-01-15 UY UY0001034576A patent/UY34576A/es not_active Application Discontinuation
-
2014
- 2014-06-11 ZA ZA2014/04314A patent/ZA201404314B/en unknown
- 2014-06-12 TN TNP2014000256A patent/TN2014000256A1/en unknown
- 2014-07-07 IL IL233541A patent/IL233541B/en active IP Right Grant
- 2014-07-08 CO CO14146898A patent/CO7000775A2/es unknown
- 2014-07-11 MA MA37199A patent/MA35858B1/fr unknown
- 2014-07-15 CU CU2014000086A patent/CU20140086A7/es unknown
- 2014-07-15 CL CL2014001863A patent/CL2014001863A1/es unknown
- 2014-07-17 CR CR20140345A patent/CR20140345A/es unknown
- 2014-07-17 GT GT201400155A patent/GT201400155A/es unknown
- 2014-07-17 PH PH12014501638A patent/PH12014501638A1/en unknown
-
2016
- 2016-02-09 US US15/018,953 patent/US20160176883A1/en not_active Abandoned
- 2016-02-26 CY CY20161100163T patent/CY1117914T1/el unknown
- 2016-03-23 SM SM201600083T patent/SMT201600083B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR22C1030I2 (fr) | Formes cristallines d'un inhibiteur de la prolyle hydroxylase | |
| SMT201600083B (it) | Nuove forme e sali di un inibitore di diidropirrolo[1,2-c]imidazolil aldosterone sintasi o aromatasi | |
| SMT201700052B (it) | 2-(azaindol-2-il)benzimidazoli come inibitori di pad4 | |
| CR20120576A (es) | Inhibidores de pirazolil quinazolina cinasa | |
| IL237582A0 (en) | Cdk inhibitors | |
| EP2710007A4 (en) | Kinase inhibitors | |
| CO6970602A2 (es) | Inhibidores de quinasa | |
| SMT201500291B (it) | Nuovi agenti antimalarici | |
| HRP20151310T1 (xx) | Spojevi piridazinona i njihova uporaba kao inhibitori daao | |
| BR112013025761A2 (pt) | inibidores de hsp90 | |
| IL224178A (en) | Heterogeneous history of cervix as hcv inhibitors | |
| LT3070091T (lt) | Benzodioksolo dariniai kaip fosfodiesterazės inhibitoriai | |
| EP2623763A4 (en) | Cylinder head | |
| EP2933248A4 (en) | NOVEL RENIN INHIBITOR | |
| IL233712A0 (en) | Sulfonamide derivatives used as mogat–2 inhibitors | |
| BR112013030341A2 (pt) | inibidores de glutaminil ciclase radiomarcados | |
| BR112013014148A2 (pt) | inibidores de corrosão | |
| EP2629616A4 (en) | SUBSTITUTED AMINO-TRIAZOLYL-PDE10-HEMMER | |
| EP2753623A4 (en) | GAMMASEKRETASEHEMMER | |
| EP2694057A4 (en) | LIPOXYGENASE INHIBITORS | |
| BR112013010699A2 (pt) | derivados de pirrolidina usados como inibidores de catepsina | |
| BR112013014484A2 (pt) | compostos inibidores de metaloenzimas | |
| EP2861071A4 (en) | ALDOSTERONSYNTHASEHEMMER | |
| IL227814A0 (en) | Cathepsin c inhibitors | |
| FI20105909A0 (fi) | Suutinpää |