GT201400155A - Nuevas formas y sales de un dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa - Google Patents

Nuevas formas y sales de un dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa

Info

Publication number
GT201400155A
GT201400155A GT201400155A GT201400155A GT201400155A GT 201400155 A GT201400155 A GT 201400155A GT 201400155 A GT201400155 A GT 201400155A GT 201400155 A GT201400155 A GT 201400155A GT 201400155 A GT201400155 A GT 201400155A
Authority
GT
Guatemala
Prior art keywords
salts
aldosterone
aromatase
imidazolilo
dihydropirrolo
Prior art date
Application number
GT201400155A
Other languages
English (en)
Inventor
Paul Sutton
Eric Loeser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47604250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201400155(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of GT201400155A publication Critical patent/GT201400155A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCIÓN SE REFIERE A UNA SAL DE FOSFATO O UNA SAL DE NITRATO DE 4- (R) -6,7- DIHIDRO-5H-PIRROLO [1, 2-C] IMIDAZOL-5-IL-3-FLUORO-BENZONITRILO QUE TIENE LA SIGUIENTE FÓRMULA: ESPECIALMENTE EN FORMA CRISTALINA, Y FORMAS ESPECÍFICAS DE ESTAS SALES, ASÍ COMO REALIZACIONES DE LA INVENCIÓN RELACIONADAS. LAS SALES Y FORMAS DE SAL PERMITEN EL TRATAMIENTO PROFILÁCTICO Y/O TERAPÉUTICO DE ENFERMEDADES Y TRASTORNOS MEDIADOS POR LA ALDOSTERONA SINTASA Y/O AROMATASA, COMO LA ENFERMEDAD DE CUSHING.
GT201400155A 2012-01-17 2014-07-17 Nuevas formas y sales de un dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa GT201400155A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261587280P 2012-01-17 2012-01-17

Publications (1)

Publication Number Publication Date
GT201400155A true GT201400155A (es) 2017-09-28

Family

ID=47604250

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201400155A GT201400155A (es) 2012-01-17 2014-07-17 Nuevas formas y sales de un dihidropirrolo [1,2-c] imidazolilo, inhibidor de la aldosterona sintasa o aromatasa

Country Status (41)

Country Link
US (2) US9334276B2 (es)
EP (1) EP2804863B1 (es)
JP (1) JP5749410B2 (es)
KR (2) KR20140093726A (es)
CN (1) CN104039793B (es)
AP (1) AP2014007762A0 (es)
AR (1) AR089728A1 (es)
AU (1) AU2013209952B2 (es)
BR (1) BR112014017260A8 (es)
CA (1) CA2863339C (es)
CL (1) CL2014001863A1 (es)
CO (1) CO7000775A2 (es)
CR (1) CR20140345A (es)
CU (1) CU20140086A7 (es)
CY (1) CY1117914T1 (es)
DK (1) DK2804863T3 (es)
EA (1) EA026232B1 (es)
ES (1) ES2564143T3 (es)
GT (1) GT201400155A (es)
HK (1) HK1198536A1 (es)
HR (1) HRP20160178T1 (es)
HU (1) HUE026984T2 (es)
IL (1) IL233541B (es)
IN (1) IN2014DN06781A (es)
JO (1) JO3137B1 (es)
MA (1) MA35858B1 (es)
MX (1) MX2014008686A (es)
NZ (1) NZ626277A (es)
PE (1) PE20142358A1 (es)
PH (1) PH12014501638A1 (es)
PL (1) PL2804863T3 (es)
RS (1) RS54589B1 (es)
SG (1) SG11201404061YA (es)
SI (1) SI2804863T1 (es)
SM (1) SMT201600083B (es)
TN (1) TN2014000256A1 (es)
TW (1) TWI609869B (es)
UA (1) UA114803C2 (es)
UY (1) UY34576A (es)
WO (1) WO2013109514A1 (es)
ZA (1) ZA201404314B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME03371B (me) * 2010-01-14 2020-01-20 Novartis Ag Upotreba agensa za modifikovanje hormona adrenalina
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
PL3166596T3 (pl) 2014-07-07 2018-11-30 Novartis Ag Farmaceutyczne postaci dawkowania
WO2016120821A1 (en) 2015-01-29 2016-08-04 Novartis Ag Process for the production of condensed imidazolo derivatives
US20160287565A1 (en) * 2015-04-06 2016-10-06 Millendo Therapeutics, Inc. Combination therapy for treating disorders associated with excess cortisol production
SG11201903803UA (en) * 2016-10-27 2019-05-30 Damian Pharma Ag Aldosterone synthase inhibitor
WO2018078049A1 (en) * 2016-10-27 2018-05-03 Damian Pharma Ag Aldosterone synthase inhibitor
CN112055590A (zh) 2018-05-03 2020-12-08 达米安制药股份公司 用于治疗醛固酮增多症的r-法屈唑

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1315449A (en) * 1918-11-15 1919-09-09 Frank B Yingling Shaper-feed.
US4617307A (en) * 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US5066656A (en) 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate
DK0625155T3 (da) 1992-01-27 2001-11-12 Janssen Pharmaceutica Nv Pyrroloimidazolyl- og imidazopyridinyl-substituerede 1H-benzimidazolderivater som aromataseinhibitorer
DE60321593D1 (de) * 2002-11-18 2008-07-24 Novartis Ag Imidazoä1,5üa pyridin-derivate und methoden zur behandlung von krankheiten in verbindung mit aldosteron
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
AU2007333904A1 (en) 2006-12-18 2008-06-26 Novartis Ag 1-substituted imidazole derivatives and their use as aldosterone synthase inhibitors
EP2507234B1 (en) 2009-11-30 2014-03-12 Novartis AG Imidazole derivatives as aldosterone synthase inhibitors
ME03371B (me) * 2010-01-14 2020-01-20 Novartis Ag Upotreba agensa za modifikovanje hormona adrenalina

Also Published As

Publication number Publication date
JO3137B1 (ar) 2017-09-20
EA026232B1 (ru) 2017-03-31
US20140364470A1 (en) 2014-12-11
RS54589B1 (en) 2016-08-31
BR112014017260A8 (pt) 2017-07-04
EA201491374A1 (ru) 2014-12-30
CA2863339A1 (en) 2013-07-25
WO2013109514A1 (en) 2013-07-25
AP2014007762A0 (en) 2014-07-31
HUE026984T2 (en) 2016-08-29
IN2014DN06781A (es) 2015-05-22
MX2014008686A (es) 2014-08-27
HK1198536A1 (en) 2015-05-15
EP2804863A1 (en) 2014-11-26
TW201335161A (zh) 2013-09-01
AU2013209952A1 (en) 2014-07-24
BR112014017260A2 (pt) 2017-06-13
CU20140086A7 (es) 2014-12-26
UY34576A (es) 2013-09-02
CO7000775A2 (es) 2014-07-21
NZ626277A (en) 2015-10-30
KR20140093726A (ko) 2014-07-28
PE20142358A1 (es) 2015-01-30
UA114803C2 (uk) 2017-08-10
JP2015503627A (ja) 2015-02-02
ZA201404314B (en) 2015-08-26
SG11201404061YA (en) 2014-08-28
PH12014501638B1 (en) 2014-10-13
CL2014001863A1 (es) 2014-11-07
AU2013209952B2 (en) 2016-09-01
CN104039793B (zh) 2017-05-10
EP2804863B1 (en) 2015-12-02
CY1117914T1 (el) 2017-05-17
CR20140345A (es) 2014-09-09
TN2014000256A1 (en) 2015-09-30
DK2804863T3 (en) 2016-03-07
PH12014501638A1 (en) 2014-10-13
US20160176883A1 (en) 2016-06-23
AR089728A1 (es) 2014-09-10
HRP20160178T1 (hr) 2016-03-25
CA2863339C (en) 2021-03-23
CN104039793A (zh) 2014-09-10
TWI609869B (zh) 2018-01-01
SI2804863T1 (sl) 2016-05-31
PL2804863T3 (pl) 2016-06-30
US9334276B2 (en) 2016-05-10
ES2564143T3 (es) 2016-03-18
IL233541A0 (en) 2014-08-31
JP5749410B2 (ja) 2015-07-15
MA35858B1 (fr) 2014-12-01
SMT201600083B (it) 2016-04-29
ES2564143T8 (es) 2020-11-18
KR20140141687A (ko) 2014-12-10
IL233541B (en) 2018-12-31

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