PE20142358A1 - Nuevas formas y sales de un dihidropirrolo[1,2-c]imidazolilo, inhibidor de la aldosterona sintasa o aromatasa - Google Patents
Nuevas formas y sales de un dihidropirrolo[1,2-c]imidazolilo, inhibidor de la aldosterona sintasa o aromatasaInfo
- Publication number
- PE20142358A1 PE20142358A1 PE2014001112A PE2014001112A PE20142358A1 PE 20142358 A1 PE20142358 A1 PE 20142358A1 PE 2014001112 A PE2014001112 A PE 2014001112A PE 2014001112 A PE2014001112 A PE 2014001112A PE 20142358 A1 PE20142358 A1 PE 20142358A1
- Authority
- PE
- Peru
- Prior art keywords
- aromatase
- aldosterone synthase
- dihydropirrole
- imidazolyl
- inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UNA SAL FOSFATO DE 4-(R)-(6,7-DIHIDRO-5H-PIRROLO[1,2-c]IMIDAZOL-5-IL)-3-FLUORO-BENZONITRILO EN FORMA CRISTALINA A QUE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X CON PICOS TALES COMO 6,0, 12,9, 15,5, 16,0, 16,3, 19,7, 20,4, 22,1, 24,3 Y 29,2 (+/-0,2 GRADOS). TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHA SAL TIENE ACTIVIDAD SOBRE LA ALDOSTERONA SINTASA Y/O AROMATASA Y ES UTIL EN EL TRATAMIENTO DE LA ENFERMEDAD DE CUSHING, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587280P | 2012-01-17 | 2012-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20142358A1 true PE20142358A1 (es) | 2015-01-30 |
Family
ID=47604250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014001112A PE20142358A1 (es) | 2012-01-17 | 2013-01-15 | Nuevas formas y sales de un dihidropirrolo[1,2-c]imidazolilo, inhibidor de la aldosterona sintasa o aromatasa |
Country Status (41)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG182393A1 (en) * | 2010-01-14 | 2012-08-30 | Novartis Ag | Use of an adrenal hormone-modifying agent |
| EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
| US10143680B2 (en) * | 2014-07-07 | 2018-12-04 | Novartis Ag | Pharmaceutical dosage forms |
| AU2016210899B2 (en) | 2015-01-29 | 2019-03-07 | Recordati Ag | Process for the production of condensed imidazolo Derivatives |
| WO2016164476A2 (en) * | 2015-04-06 | 2016-10-13 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
| BR112019007954A2 (pt) * | 2016-10-27 | 2019-07-02 | Damian Pharma Ag | inibidor da aldosterona sintase |
| WO2018078049A1 (en) * | 2016-10-27 | 2018-05-03 | Damian Pharma Ag | Aldosterone synthase inhibitor |
| MX2020011471A (es) | 2018-05-03 | 2020-12-07 | Damian Pharma Ag | R-fadrozol para usar en el tratamiento de aldosteronismo. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1315449A (en) * | 1918-11-15 | 1919-09-09 | Frank B Yingling | Shaper-feed. |
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5066656A (en) | 1989-11-01 | 1991-11-19 | Janssen Pharmaceutica N.V. | Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives |
| MTP1076B (en) * | 1990-01-12 | 1991-09-30 | Ciba Geigy Ag | Hemihydrate |
| CA2127689A1 (en) | 1992-01-27 | 1993-08-05 | Marcel A. C. Janssen | Pyrroloimidazolyl and imidazopyridinyl substituted 1h-benzimidazole derivatives as aromatase inhibitors |
| EP1565463B1 (en) * | 2002-11-18 | 2008-06-11 | Novartis AG | Imidazo[1,5a] pyridine derivatives and methods for treating aldosterone mediated diseases |
| GT200600381A (es) * | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| US20100041722A1 (en) | 2006-12-18 | 2010-02-18 | Qi-Ying Hu | Organic compounds |
| JP5575913B2 (ja) | 2009-11-30 | 2014-08-20 | ノバルティス アーゲー | アルドステロン合成酵素阻害剤としてのイミダゾール誘導体 |
| SG182393A1 (en) * | 2010-01-14 | 2012-08-30 | Novartis Ag | Use of an adrenal hormone-modifying agent |
-
2013
- 2013-01-15 JP JP2014552375A patent/JP5749410B2/ja active Active
- 2013-01-15 TW TW102101537A patent/TWI609869B/zh not_active IP Right Cessation
- 2013-01-15 AR ARP130100119A patent/AR089728A1/es unknown
- 2013-01-15 PL PL13701194T patent/PL2804863T3/pl unknown
- 2013-01-15 JO JOP/2013/0014A patent/JO3137B1/ar active
- 2013-01-15 CN CN201380005054.0A patent/CN104039793B/zh active Active
- 2013-01-15 BR BR112014017260A patent/BR112014017260A8/pt not_active Application Discontinuation
- 2013-01-15 UA UAA201406492A patent/UA114803C2/uk unknown
- 2013-01-15 AU AU2013209952A patent/AU2013209952B2/en active Active
- 2013-01-15 PE PE2014001112A patent/PE20142358A1/es not_active Application Discontinuation
- 2013-01-15 DK DK13701194.6T patent/DK2804863T3/en active
- 2013-01-15 SG SG11201404061YA patent/SG11201404061YA/en unknown
- 2013-01-15 ES ES13701194.6T patent/ES2564143T3/es active Active
- 2013-01-15 KR KR1020147016954A patent/KR20140093726A/ko not_active Application Discontinuation
- 2013-01-15 RS RS20160109A patent/RS54589B1/en unknown
- 2013-01-15 AP AP2014007762A patent/AP2014007762A0/xx unknown
- 2013-01-15 WO PCT/US2013/021521 patent/WO2013109514A1/en active Application Filing
- 2013-01-15 NZ NZ626277A patent/NZ626277A/en not_active IP Right Cessation
- 2013-01-15 HU HUE13701194A patent/HUE026984T2/en unknown
- 2013-01-15 MX MX2014008686A patent/MX2014008686A/es unknown
- 2013-01-15 UY UY0001034576A patent/UY34576A/es not_active Application Discontinuation
- 2013-01-15 CA CA2863339A patent/CA2863339C/en active Active
- 2013-01-15 SI SI201330142A patent/SI2804863T1/sl unknown
- 2013-01-15 EA EA201491374A patent/EA026232B1/ru not_active IP Right Cessation
- 2013-01-15 US US14/370,124 patent/US9334276B2/en active Active
- 2013-01-15 EP EP13701194.6A patent/EP2804863B1/en active Active
- 2013-01-15 IN IN6781DEN2014 patent/IN2014DN06781A/en unknown
- 2013-01-15 KR KR20147030158A patent/KR20140141687A/ko not_active Application Discontinuation
-
2014
- 2014-06-11 ZA ZA2014/04314A patent/ZA201404314B/en unknown
- 2014-06-12 TN TNP2014000256A patent/TN2014000256A1/en unknown
- 2014-07-07 IL IL233541A patent/IL233541B/en active IP Right Grant
- 2014-07-08 CO CO14146898A patent/CO7000775A2/es unknown
- 2014-07-11 MA MA37199A patent/MA35858B1/fr unknown
- 2014-07-15 CL CL2014001863A patent/CL2014001863A1/es unknown
- 2014-07-15 CU CU2014000086A patent/CU20140086A7/es unknown
- 2014-07-17 CR CR20140345A patent/CR20140345A/es unknown
- 2014-07-17 PH PH12014501638A patent/PH12014501638A1/en unknown
- 2014-07-17 GT GT201400155A patent/GT201400155A/es unknown
- 2014-11-28 HK HK14112037.4A patent/HK1198536A1/xx unknown
-
2016
- 2016-02-09 US US15/018,953 patent/US20160176883A1/en not_active Abandoned
- 2016-02-19 HR HRP20160178T patent/HRP20160178T1/hr unknown
- 2016-02-26 CY CY20161100163T patent/CY1117914T1/el unknown
- 2016-03-23 SM SM201600083T patent/SMT201600083B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20142358A1 (es) | Nuevas formas y sales de un dihidropirrolo[1,2-c]imidazolilo, inhibidor de la aldosterona sintasa o aromatasa | |
| CL2014002386A1 (es) | Compuesto inhibidor de cinasa de fosfoinositida 3 en forma anhidra cristalina solida; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento o prevencion de enfermedades tales como epoc, asma, entre otras. | |
| CL2013002341A1 (es) | Compuestos derivados de 6-ciclobutil-1,5-dihidro-pirazolo [3,4 d]pirimidin-4-ona, inhibidores de pde9a; composicion farmaceutica; y su uso para el tratamiento de una enfermedad o afección relacionado con deterioro cognitivo, enfermedad de alzheimer, demencia vascular, entre otros | |
| UY35115A (es) | Imidazo[1,2-a]piridincarboxamidas aminosustituidas y su uso | |
| EP2773637A4 (en) | BENZOLSULFONAMIDE COMPOUNDS AND THEIR USE AS MEDICAMENTS | |
| CO6930363A2 (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
| CL2013002688A1 (es) | Compuestos derivados de 1,4-diazabiciclo[3,2,2]-nonano, quinuclidina, 1-azabiciclo[2,2,2]-octilo sustituidas; y uso como inhibidores de glucosilceramida sintasa, utiles en el tratamiento de enfermedades metabolicas, tales como almacenamiento lisosomico, solo en combinacion con terapia de reemplazo enzimatico y para el tratamiento del cancer. | |
| BR112015003376A8 (pt) | composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e usos de quantidade eficiente de composto ou sal farmaceuticamente aceitável do mesmo ou composição farmacêutica | |
| CU20120161A7 (es) | 5-fluoro-1h-pirazolopiridinas sustituidas | |
| CU20150163A7 (es) | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET | |
| PL2768937T3 (pl) | Preparaty, ich zastosowanie jako środków do mycia naczyń lub do wytwarzania środków do mycia naczyń i ich wytwarzanie | |
| EA201291310A1 (ru) | Композиция ингибитора jak для местного применения | |
| CL2014002326A1 (es) | Combinacion que comprende benzodioxanos y uno o mas agentes activos y su uso en el tratamiento de enfermedades tales como ateroesclerosis e infarto al miocardio. | |
| CO6791606A2 (es) | Composiciones y métodos para el tratamiento en aplicaciones clínicas de amplio espectro, no diferenciadas o combinadas | |
| CL2013001947A1 (es) | Composicion farmaceutica que comprende pioglitazona; uso de pioglitazona para tratar alzheimer; composicion que comprende pioglitazona. | |
| CL2012002317A1 (es) | Compuestos derivados de tienopirimidinas, inhibitores de quinasas mnk1/mnk2; composicion farmaceutica; y su uso para elt ratamiento o profilaxis de enfermedades metabolicas, tales como diabetes, daño renal, cancer, enfermedades inflamatorias, entre otras. | |
| CL2013000735A1 (es) | Uso de una composicion que comprende compuestos derivados de 1-h-imidazol-4-il sustituido para el tratamiento de enfermedades y condiciones de la piel, tales como rosacea, daño solar cronico, psoriasis, entre otras; kit farmaceutico. | |
| PT2804475T (pt) | Criopreservação de células, tecidos e órgãos | |
| BR112014020992A2 (pt) | Composto,uso de composto na fabricação de um medicamento e composição farmacêutica | |
| BR112014026828A2 (pt) | compostos de triazolo como inibidores de pde10 | |
| CL2013001482A1 (es) | Compuestos derivados de 3-metil-7-oxo-4-tia-1-aza-biciclo[3.2.0]heptano para utilizarse en la inhibicion de beta-lactamasas producidas por bacterias y restaurar/potenciar la actividad de antibioticos; y composicion farmaceutica que los comprende. | |
| BR112015029894A2 (pt) | forma de dosagem farmacêutica sólida | |
| WO2011117378A3 (en) | Compositions comprising brimonidine for the treatment of erythema | |
| EP2818154A4 (en) | TOPICAL PREPARATION FOR SKIN AND CELL ACTIVATION AGENT FOR HEALTHY SKIN | |
| EP2636414A4 (en) | PREVENTIVE OR THERAPEUTIC AGENT FOR PAIN ASSOCIATED WITH ACUTE ZONES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |