CL2014002326A1 - Combinacion que comprende benzodioxanos y uno o mas agentes activos y su uso en el tratamiento de enfermedades tales como ateroesclerosis e infarto al miocardio. - Google Patents
Combinacion que comprende benzodioxanos y uno o mas agentes activos y su uso en el tratamiento de enfermedades tales como ateroesclerosis e infarto al miocardio.Info
- Publication number
- CL2014002326A1 CL2014002326A1 CL2014002326A CL2014002326A CL2014002326A1 CL 2014002326 A1 CL2014002326 A1 CL 2014002326A1 CL 2014002326 A CL2014002326 A CL 2014002326A CL 2014002326 A CL2014002326 A CL 2014002326A CL 2014002326 A1 CL2014002326 A1 CL 2014002326A1
- Authority
- CL
- Chile
- Prior art keywords
- benzodioxanes
- atherosclerosis
- diseases
- treatment
- combination
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 239000013543 active substance Substances 0.000 title 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical class C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000010125 myocardial infarction Diseases 0.000 title 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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KR101893756B1 (ko) | 2011-03-14 | 2018-09-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 류코트리엔 생성의 벤조디옥산 억제제 |
WO2013012844A1 (en) | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
AR091315A1 (es) * | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
MX2014010563A (es) | 2012-03-06 | 2014-12-05 | Boehringer Ingelheim Int | Benzodioxanos en combinacion con otros activos para inhibir la produccion de leucotrieno. |
US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
KR102153557B1 (ko) | 2013-03-27 | 2020-09-09 | 에프. 호프만-라 로슈 아게 | 치료에 대한 반응성을 예측하기 위한 유전 마커 |
EP3022193B1 (en) | 2013-07-15 | 2017-04-26 | Boehringer Ingelheim International GmbH | Inhibitors of leukotriene production |
US9573957B2 (en) | 2013-07-15 | 2017-02-21 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
ES2825675T3 (es) | 2014-07-30 | 2021-05-17 | Hoffmann La Roche | Marcadores genéticos para predecir la reactividad al tratamiento con un agente que aumenta las HDL o que imita las HDL |
US10968193B2 (en) * | 2014-08-08 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
CN104181252B (zh) * | 2014-09-01 | 2015-12-02 | 广东东阳光药业有限公司 | 一种分离检测安塞曲匹及其异构体的方法 |
CN105748469B (zh) * | 2016-02-24 | 2019-07-23 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹辛伐他汀药物组合物 |
US10610520B2 (en) | 2016-03-31 | 2020-04-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
EP4196478A1 (en) | 2020-08-14 | 2023-06-21 | Novartis AG | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
CN112076189B (zh) * | 2020-09-23 | 2021-11-12 | 唐怡庭 | 一种酰胺化合物在制备治疗脓毒症药物中的应用 |
AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
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US498770A (en) * | 1893-06-06 | Electrolytic apparatus | ||
US4918092A (en) * | 1983-12-21 | 1990-04-17 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
US5585492A (en) | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
DE19705450A1 (de) | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
DE19821003A1 (de) | 1998-05-11 | 1999-11-18 | Dresden Arzneimittel | Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2425280A1 (en) | 2000-10-26 | 2002-05-02 | Pfizer Products Inc. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
CA2509413C (en) | 2002-12-20 | 2012-05-01 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
DK1841757T3 (da) | 2005-01-07 | 2010-09-13 | Pfizer Prod Inc | Heteroaromatiske quinolin-forbindelser og deres anvendelse som PDE10-hæmmere |
CA2603122A1 (en) | 2005-03-31 | 2006-10-05 | Janssen Pharmaceutica N.V. | Phenyl and pyridyl lta4h modulators |
NZ566788A (en) | 2005-09-21 | 2012-10-26 | Decode Genetics Ehf | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation |
US7750012B2 (en) | 2005-12-21 | 2010-07-06 | Decode Genetics Ehf | Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation |
CA2634699A1 (en) | 2005-12-21 | 2007-06-28 | Decode Genetics Ehf | N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation |
AR063373A1 (es) | 2006-10-24 | 2009-01-21 | Wyeth Corp | Derivados de benzodioxano y sus usos |
DK2336125T3 (da) | 2008-04-11 | 2013-04-08 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl- og thioazolopyrazin-2-yloxy-phenyl-aminer som modulatorer af leukotrien-A4-hydrolase |
BRPI1014039A2 (pt) | 2009-04-08 | 2018-04-03 | Actelion Pharmaceuticals Ltd | 6-(3-aza-biciclo[3.1.0]hex-3-il)-2-fenil-pirimidinas |
US9481675B2 (en) | 2009-09-11 | 2016-11-01 | Merck Sharp & Dohme Corp. | Gyrase inhibitors |
CN102946877B (zh) | 2010-03-18 | 2019-07-05 | 香港科技大学 | 乳突果及其分离的化合物在制备用于治疗神经疾病的药物中的用途 |
KR101893756B1 (ko) * | 2011-03-14 | 2018-09-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 류코트리엔 생성의 벤조디옥산 억제제 |
WO2013012844A1 (en) | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
MX2014010563A (es) | 2012-03-06 | 2014-12-05 | Boehringer Ingelheim Int | Benzodioxanos en combinacion con otros activos para inhibir la produccion de leucotrieno. |
US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
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EA201400976A1 (ru) | 2015-02-27 |
NZ628587A (en) | 2016-07-29 |
PH12014501967B1 (en) | 2014-11-17 |
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AR090259A1 (es) | 2014-10-29 |
JP2015513552A (ja) | 2015-05-14 |
MX2014010563A (es) | 2014-12-05 |
KR20140138851A (ko) | 2014-12-04 |
JP6080226B2 (ja) | 2017-02-15 |
US9662339B2 (en) | 2017-05-30 |
US20130236468A1 (en) | 2013-09-12 |
EP2822941A1 (en) | 2015-01-14 |
AU2013229560A1 (en) | 2014-08-28 |
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