MA33904B1 - Utilisation d'un agent de modification d'hormones surrénaliennes - Google Patents

Utilisation d'un agent de modification d'hormones surrénaliennes

Info

Publication number
MA33904B1
MA33904B1 MA35039A MA35039A MA33904B1 MA 33904 B1 MA33904 B1 MA 33904B1 MA 35039 A MA35039 A MA 35039A MA 35039 A MA35039 A MA 35039A MA 33904 B1 MA33904 B1 MA 33904B1
Authority
MA
Morocco
Prior art keywords
change factor
adrenal hormone
hormone change
subject
adrenal
Prior art date
Application number
MA35039A
Other languages
Arabic (ar)
English (en)
Inventor
Qi-Ying Hu
Gary Ksander
Erik Meredith
Lauren G Monovich
Julien Papillon
Christoph Schumacher
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43735742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33904(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33904B1 publication Critical patent/MA33904B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un procédé de traitement d'une maladie ou d'un trouble caractérisé par des taux accrus de l'hormone du stress et/ou des taux diminués d'hormones androgènes dans un sujet. Ce procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'un composé représenté par la formule (i) : dans laquelle n vaut 1 ou 3 ; r représente l'hydrogène ou c(o)n(r
MA35039A 2010-01-14 2011-01-13 Utilisation d'un agent de modification d'hormones surrénaliennes MA33904B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29498010P 2010-01-14 2010-01-14
PCT/US2011/021100 WO2011088188A1 (fr) 2010-01-14 2011-01-13 Utilisation d'un agent de modification d'hormones surrénaliennes

Publications (1)

Publication Number Publication Date
MA33904B1 true MA33904B1 (fr) 2013-01-02

Family

ID=43735742

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35039A MA33904B1 (fr) 2010-01-14 2011-01-13 Utilisation d'un agent de modification d'hormones surrénaliennes

Country Status (34)

Country Link
US (2) US8609862B2 (fr)
EP (2) EP3527208A1 (fr)
JP (4) JP5602250B2 (fr)
KR (1) KR101412206B1 (fr)
CN (2) CN102711916B (fr)
AU (1) AU2011205290C1 (fr)
BR (1) BR112012017458B1 (fr)
CA (1) CA2786443C (fr)
CL (1) CL2012001961A1 (fr)
CY (2) CY1121320T1 (fr)
DK (1) DK2523731T3 (fr)
ES (1) ES2707596T3 (fr)
HR (1) HRP20190064T1 (fr)
HU (2) HUE041967T2 (fr)
IL (1) IL220804A0 (fr)
LT (2) LT2523731T (fr)
LU (1) LUC00159I2 (fr)
MA (1) MA33904B1 (fr)
ME (1) ME03371B (fr)
MX (2) MX354022B (fr)
NL (1) NL301043I2 (fr)
NO (1) NO2020012I1 (fr)
NZ (1) NZ601077A (fr)
PH (1) PH12012501422B1 (fr)
PL (1) PL2523731T3 (fr)
PT (1) PT2523731T (fr)
RS (1) RS58234B1 (fr)
RU (1) RU2598708C2 (fr)
SG (1) SG182393A1 (fr)
SI (1) SI2523731T1 (fr)
TN (1) TN2012000352A1 (fr)
TR (1) TR201900515T4 (fr)
WO (1) WO2011088188A1 (fr)
ZA (1) ZA201205058B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2786443C (fr) * 2010-01-14 2018-12-11 Novartis Ag Utilisation d'un agent de modification d'hormones surrenaliennes
JP2013528658A (ja) 2010-06-16 2013-07-11 エンベラ ニューロセラピューティクス，インコーポレイティド 依存、精神疾患、及び神経変性病の治療のための組成物と方法
TWI518073B (zh) 2011-06-14 2016-01-21 美國禮來大藥廠 醛固酮合成酶抑制劑
WO2013043518A1 (fr) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Composés imidazopyridyliques utilisables en tant qu'inhibiteurs de l'aldostérone synthase
WO2013043521A1 (fr) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Composés pyrazolopyridyle à utiliser en tant qu'inhibiteurs de l'aldostérone synthase
WO2013043520A1 (fr) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Composés triazolopyridyle à utiliser en tant qu'inhibiteurs de l'aldostérone synthase
WO2013109514A1 (fr) * 2012-01-17 2013-07-25 Novartis Ag Nouvelles formes et sels d'un inhibiteur de l'aldostérone synthase imidazole dihydropyrrolo [1,2-c] ou ou de l'inhibiteur de l'aromatase
RU2663455C2 (ru) * 2012-04-12 2018-08-06 Новартис Аг КОМБИНАЦИЯ АНАЛОГОВ СОМАТОСТАТИНА С ИНГИБИТОРАМИ 11β- ГИДРОКСИЛАЗЫ
US9550750B2 (en) 2012-10-05 2017-01-24 Merck Sharp & Dohme Corp. Indoline compounds as aldosterone synthase inhibitors
JP2015093832A (ja) * 2013-11-08 2015-05-18 日本メジフィジックス株式会社 放射性ハロゲン標識化合物又はその塩、これを含む医薬
TWI707682B (zh) 2014-07-07 2020-10-21 瑞士商瑞科戴迪股份有限公司 醫藥劑型
WO2016048984A1 (fr) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Méthodes et compositions pour le traitement du syndrome de cushing basées sur le 2s,4r kétoconazole
RU2734818C2 (ru) 2015-01-29 2020-10-23 Рекордати АГ Способ получения конденсированных производных имидазола
WO2016164476A2 (fr) 2015-04-06 2016-10-13 Millendo Therapeutics, Inc. Polythérapie pour le traitement de troubles liés à un excès de production de cortisol
EP3310358A4 (fr) * 2015-06-22 2019-08-28 Embera Neurotherapeutics, Inc. Compositions et procédés pour le traitement de troubles d'utilisation de substances, d'accoutumance, et de troubles psychiatriques
BR112019018700A2 (pt) 2017-03-10 2020-04-07 Embera Neurotherapeutics Inc composições farmacêuticas e seus usos

Family Cites Families (22)

* Cited by examiner, † Cited by third party
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US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US4814333A (en) 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
US5658881A (en) 1994-10-14 1997-08-19 Twk, Inc. Method for topical inhibition of the metabolic activity of cytochrome P450
DE19814087A1 (de) 1998-03-30 1999-10-14 Lohmann Therapie Syst Lts Feuchtigkeitsaktivierbares therapeutisches System
EP1121111B1 (fr) 1998-10-15 2010-02-10 Imperial Innovations Limited Compositions pour traiter la perte de poids
ES2275853T3 (es) * 2001-02-16 2007-06-16 Aventis Pharmaceuticals Inc. Derivados heterociclicos de urea y su uso como ligandos de receptores de dopamina d3.
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
GB0212412D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
JP5138875B2 (ja) 2005-07-19 2013-02-06 株式会社デンソー センサ装置
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
AR056888A1 (es) 2005-12-09 2007-10-31 Speedel Experimenta Ag Derivados de heterociclil imidazol
WO2007105203A2 (fr) 2006-03-16 2007-09-20 Yeda Research And Development Co. Ltd. Procede et composition pour la protection du tissu neuronal de degats induits par des niveaux eleves de glutamate
AU2007267793A1 (en) * 2006-05-26 2007-12-06 Novartis Ag Aldosterone synthase and/or 11beta-hydroxylase inhibitors
EP1886695A1 (fr) 2006-06-27 2008-02-13 Speedel Experimenta AG Combinaisons pharmacéutiques avec inhibiteurs de l'aldosterone synthase et antagonistes du recepteur de glucocorticoides où inhibiteurs de la synthese de cortisol où antagonistes du facteur de libération de la corticotropine
RU2009110442A (ru) * 2006-08-25 2010-09-27 Новартис АГ (CH) Конденсированные производные имидазола для лечения нарушений, опосредованных альдостеронсинтазой, и/или 11-бета-гидроксилазой, и/или ароматазой
AU2007333902A1 (en) * 2006-12-18 2008-06-26 Novartis Ag 4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors
EP2095819A1 (fr) 2008-02-28 2009-09-02 Maastricht University Dérivés de N-benzyle imidazole et leur utilisation comme inhibiteurs de l'aldosterone synthase
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
CA2786443C (fr) * 2010-01-14 2018-12-11 Novartis Ag Utilisation d'un agent de modification d'hormones surrenaliennes
WO2013109514A1 (fr) * 2012-01-17 2013-07-25 Novartis Ag Nouvelles formes et sels d'un inhibiteur de l'aldostérone synthase imidazole dihydropyrrolo [1,2-c] ou ou de l'inhibiteur de l'aromatase
RU2663455C2 (ru) * 2012-04-12 2018-08-06 Новартис Аг КОМБИНАЦИЯ АНАЛОГОВ СОМАТОСТАТИНА С ИНГИБИТОРАМИ 11β- ГИДРОКСИЛАЗЫ

Also Published As

Publication number Publication date
MX2012008212A (es) 2012-08-03
KR101412206B1 (ko) 2014-06-25
MX354022B (es) 2018-02-08
JP2018150326A (ja) 2018-09-27
ZA201205058B (en) 2014-04-30
LT2523731T (lt) 2019-02-11
SI2523731T1 (sl) 2019-02-28
PL2523731T3 (pl) 2019-04-30
JP5602250B2 (ja) 2014-10-08
EP2523731B1 (fr) 2018-10-24
JP6181610B2 (ja) 2017-08-16
LUC00159I1 (fr) 2020-06-16
HUS2000018I1 (hu) 2020-07-28
BR112012017458B1 (pt) 2020-10-20
AU2011205290C1 (en) 2014-11-06
US9434754B2 (en) 2016-09-06
US20120295888A1 (en) 2012-11-22
HRP20190064T1 (hr) 2019-03-08
PH12012501422B1 (en) 2018-09-12
DK2523731T3 (en) 2019-02-04
BR112012017458A2 (pt) 2017-12-19
AU2011205290A1 (en) 2012-08-02
NO2020012I1 (no) 2020-06-09
IL220804A0 (en) 2012-08-30
CA2786443A1 (fr) 2011-07-21
RS58234B1 (sr) 2019-03-29
PT2523731T (pt) 2019-01-21
ME03371B (fr) 2020-01-20
JP2015013859A (ja) 2015-01-22
KR20120116482A (ko) 2012-10-22
RU2598708C2 (ru) 2016-09-27
WO2011088188A1 (fr) 2011-07-21
US8609862B2 (en) 2013-12-17
ES2707596T3 (es) 2019-04-04
LTC2523731I2 (lt) 2022-05-10
CY1121320T1 (el) 2020-05-29
HUS000508I2 (hu) 2021-03-29
LTPA2020512I1 (lt) 2020-07-27
TN2012000352A1 (en) 2014-01-30
JP2013517280A (ja) 2013-05-16
NZ601077A (en) 2014-07-25
HUE041967T2 (hu) 2019-06-28
NL301043I2 (nl) 2020-07-06
SG182393A1 (en) 2012-08-30
US20140171392A1 (en) 2014-06-19
TR201900515T4 (tr) 2019-02-21
CN102711916B (zh) 2015-09-02
JP6425688B2 (ja) 2018-11-21
CN105440038A (zh) 2016-03-30
CY2020018I1 (el) 2020-11-25
CN102711916A (zh) 2012-10-03
AU2011205290B2 (en) 2014-06-26
RU2012134510A (ru) 2014-02-20
CA2786443C (fr) 2018-12-11
NL301043I1 (nl) 2020-06-17
LUC00159I2 (fr) 2021-07-06
CL2012001961A1 (es) 2013-03-22
EP3527208A1 (fr) 2019-08-21
EP2523731A1 (fr) 2012-11-21
CY2020018I2 (el) 2020-11-25
PH12012501422A1 (en) 2012-10-22
JP2017002063A (ja) 2017-01-05

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