CL2012001961A1 - Método para tratar una enfermedad o trastorno en que aumentan los niveles de hormonas de estrés y/o disminuyen los niveles de hormonas de andrógenos, en que se administra un compuesto pirrolo-[1,2-c]-imidazol-bencil sustituido; su uso en insuficiencia cardíaca, entre otros; y compuestos pirrolo-[1,2-c]-imidazol-bencil sustituidos. - Google Patents

Método para tratar una enfermedad o trastorno en que aumentan los niveles de hormonas de estrés y/o disminuyen los niveles de hormonas de andrógenos, en que se administra un compuesto pirrolo-[1,2-c]-imidazol-bencil sustituido; su uso en insuficiencia cardíaca, entre otros; y compuestos pirrolo-[1,2-c]-imidazol-bencil sustituidos.

Info

Publication number
CL2012001961A1
CL2012001961A1 CL2012001961A CL2012001961A CL2012001961A1 CL 2012001961 A1 CL2012001961 A1 CL 2012001961A1 CL 2012001961 A CL2012001961 A CL 2012001961A CL 2012001961 A CL2012001961 A CL 2012001961A CL 2012001961 A1 CL2012001961 A1 CL 2012001961A1
Authority
CL
Chile
Prior art keywords
imidazol
levels
substituted pyrrolo
benzyl
hormones
Prior art date
Application number
CL2012001961A
Other languages
English (en)
Inventor
Qi-Ying Hu
Gary Ksander
Erik Meredith
Lauren G Monovich
Julien Papillon
Christoph Schumacher
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43735742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012001961(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2012001961A1 publication Critical patent/CL2012001961A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/6506Five-membered rings having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Método para tratar una enfermedad o trastorno en que aumentan los niveles de hormonas de estrés y/o disminuyen los niveles de hormonas de andrógenos, en que se administra un compuesto pirrolo-[1,2-c]-imidazol-bencil sustituido; su uso en insuficiencia cardíaca, entre otros; y compuestos pirrolo-[1,2-c]-imidazol-bencil sustituidos.
CL2012001961A 2010-01-14 2012-07-13 Método para tratar una enfermedad o trastorno en que aumentan los niveles de hormonas de estrés y/o disminuyen los niveles de hormonas de andrógenos, en que se administra un compuesto pirrolo-[1,2-c]-imidazol-bencil sustituido; su uso en insuficiencia cardíaca, entre otros; y compuestos pirrolo-[1,2-c]-imidazol-bencil sustituidos. CL2012001961A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29498010P 2010-01-14 2010-01-14

Publications (1)

Publication Number Publication Date
CL2012001961A1 true CL2012001961A1 (es) 2013-03-22

Family

ID=43735742

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012001961A CL2012001961A1 (es) 2010-01-14 2012-07-13 Método para tratar una enfermedad o trastorno en que aumentan los niveles de hormonas de estrés y/o disminuyen los niveles de hormonas de andrógenos, en que se administra un compuesto pirrolo-[1,2-c]-imidazol-bencil sustituido; su uso en insuficiencia cardíaca, entre otros; y compuestos pirrolo-[1,2-c]-imidazol-bencil sustituidos.

Country Status (33)

Country Link
US (2) US8609862B2 (es)
EP (2) EP2523731B1 (es)
JP (4) JP5602250B2 (es)
KR (1) KR101412206B1 (es)
CN (2) CN102711916B (es)
AU (1) AU2011205290C1 (es)
BR (1) BR112012017458B1 (es)
CA (1) CA2786443C (es)
CL (1) CL2012001961A1 (es)
CY (2) CY1121320T1 (es)
DK (1) DK2523731T3 (es)
ES (1) ES2707596T3 (es)
HR (1) HRP20190064T1 (es)
HU (2) HUE041967T2 (es)
IL (1) IL220804A0 (es)
LT (2) LT2523731T (es)
LU (1) LUC00159I2 (es)
MA (1) MA33904B1 (es)
ME (1) ME03371B (es)
MX (2) MX2012008212A (es)
NL (1) NL301043I2 (es)
NO (1) NO2020012I1 (es)
NZ (1) NZ601077A (es)
PL (1) PL2523731T3 (es)
PT (1) PT2523731T (es)
RS (1) RS58234B1 (es)
RU (1) RU2598708C2 (es)
SG (1) SG182393A1 (es)
SI (1) SI2523731T1 (es)
TN (1) TN2012000352A1 (es)
TR (1) TR201900515T4 (es)
WO (1) WO2011088188A1 (es)
ZA (1) ZA201205058B (es)

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KR101412206B1 (ko) * 2010-01-14 2014-06-25 노파르티스 아게 부신 호르몬 조절제의 용도
US9078886B2 (en) 2010-06-16 2015-07-14 Embera Neurotherapeutics, Inc. Compositions for the treatment of addiction, psychiatric disorders, and neurodegenerative disease
AR086665A1 (es) 2011-06-14 2014-01-15 Lilly Co Eli Inhibidor de aldosterona sintasa y composiciones farmaceuticas
EP2757884B1 (en) 2011-09-22 2022-07-27 Merck Sharp & Dohme LLC Pyrazolopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (en) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
EP2757882B1 (en) 2011-09-22 2020-11-04 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
UA114803C2 (uk) * 2012-01-17 2017-08-10 Новартіс Аг ФОРМИ І СОЛІ ДИГІДРОПІРОЛ[1,2-c]ІМІДАЗОЛІЛЬНОГО ІНГІБІТОРА АЛЬДОСТЕРОНСИНТАЗИ АБО АРОМАТАЗИ
AU2013246908B2 (en) * 2012-04-12 2016-06-30 Novartis Ag Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors
CA2886117C (en) 2012-10-05 2022-05-31 Merck Sharp & Dohme Corp. Indoline compounds and their use as aldosterone synthase inhibitors
JP2015093832A (ja) * 2013-11-08 2015-05-18 日本メジフィジックス株式会社 放射性ハロゲン標識化合物又はその塩、これを含む医薬
US10143680B2 (en) 2014-07-07 2018-12-04 Novartis Ag Pharmaceutical dosage forms
WO2016048984A1 (en) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole
PT3250555T (pt) 2015-01-29 2021-04-27 Recordati Ag Processo para a produção de derivados de imidazolo condensado
US20160287565A1 (en) 2015-04-06 2016-10-06 Millendo Therapeutics, Inc. Combination therapy for treating disorders associated with excess cortisol production
JP2018518524A (ja) * 2015-06-22 2018-07-12 エンベラ ニューロセラピューティクス,インコーポレイティド 物質使用障害、依存症及び精神障害の治療のための組成物及び方法
CA3055940A1 (en) 2017-03-10 2018-09-13 Embera Neurotherapeutics, Inc. Pharmaceutical compositions and uses thereof

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US4889861A (en) * 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US4814333A (en) 1987-07-28 1989-03-21 The Trustees Of Dartmouth College Method for treatment of hypercortisolemic, depressed patients
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
US5658881A (en) 1994-10-14 1997-08-19 Twk, Inc. Method for topical inhibition of the metabolic activity of cytochrome P450
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US7417038B1 (en) 1998-10-15 2008-08-26 Imperial Innovations Limited Methods of treating cachexia
ES2275853T3 (es) 2001-02-16 2007-06-16 Aventis Pharmaceuticals Inc. Derivados heterociclicos de urea y su uso como ligandos de receptores de dopamina d3.
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
GB0212412D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
JP5138875B2 (ja) 2005-07-19 2013-02-06 株式会社デンソー センサ装置
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
AR056888A1 (es) 2005-12-09 2007-10-31 Speedel Experimenta Ag Derivados de heterociclil imidazol
WO2007105203A2 (en) 2006-03-16 2007-09-20 Yeda Research And Development Co. Ltd. Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels
BRPI0712557A2 (pt) 2006-05-26 2013-07-02 Novartis Ag inibidores de aldosterona sintase e/ou 11 beta-hidrolase
EP1886695A1 (en) 2006-06-27 2008-02-13 Speedel Experimenta AG Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
CA2660701A1 (en) * 2006-08-25 2008-03-06 Novartis Ag Fused imidazole derivatives for the treatment of disorders mediated by aldosterone synthase and/or 11-beta-hydroxylase and/or aromatase
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EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
KR101412206B1 (ko) * 2010-01-14 2014-06-25 노파르티스 아게 부신 호르몬 조절제의 용도
UA114803C2 (uk) * 2012-01-17 2017-08-10 Новартіс Аг ФОРМИ І СОЛІ ДИГІДРОПІРОЛ[1,2-c]ІМІДАЗОЛІЛЬНОГО ІНГІБІТОРА АЛЬДОСТЕРОНСИНТАЗИ АБО АРОМАТАЗИ
AU2013246908B2 (en) * 2012-04-12 2016-06-30 Novartis Ag Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
BR112012017458B1 (pt) 2020-10-20
LUC00159I1 (es) 2020-06-16
CY1121320T1 (el) 2020-05-29
WO2011088188A1 (en) 2011-07-21
LTPA2020512I1 (lt) 2020-07-27
PT2523731T (pt) 2019-01-21
US20120295888A1 (en) 2012-11-22
KR20120116482A (ko) 2012-10-22
KR101412206B1 (ko) 2014-06-25
NZ601077A (en) 2014-07-25
DK2523731T3 (en) 2019-02-04
NL301043I1 (nl) 2020-06-17
NO2020012I1 (no) 2020-06-09
EP2523731A1 (en) 2012-11-21
HUE041967T2 (hu) 2019-06-28
JP6425688B2 (ja) 2018-11-21
CY2020018I1 (el) 2020-11-25
LTC2523731I2 (lt) 2022-05-10
ES2707596T3 (es) 2019-04-04
ME03371B (me) 2020-01-20
US9434754B2 (en) 2016-09-06
MX2012008212A (es) 2012-08-03
RS58234B1 (sr) 2019-03-29
IL220804A0 (en) 2012-08-30
CA2786443C (en) 2018-12-11
EP3527208A1 (en) 2019-08-21
US8609862B2 (en) 2013-12-17
TR201900515T4 (tr) 2019-02-21
AU2011205290A1 (en) 2012-08-02
CN105440038A (zh) 2016-03-30
JP2018150326A (ja) 2018-09-27
BR112012017458A2 (pt) 2017-12-19
EP2523731B1 (en) 2018-10-24
US20140171392A1 (en) 2014-06-19
TN2012000352A1 (en) 2014-01-30
CN102711916B (zh) 2015-09-02
NL301043I2 (nl) 2020-07-06
AU2011205290B2 (en) 2014-06-26
JP5602250B2 (ja) 2014-10-08
JP2017002063A (ja) 2017-01-05
ZA201205058B (en) 2014-04-30
MX354022B (es) 2018-02-08
CA2786443A1 (en) 2011-07-21
MA33904B1 (fr) 2013-01-02
HUS000508I2 (hu) 2021-03-29
CY2020018I2 (el) 2020-11-25
LUC00159I2 (es) 2021-07-06
PL2523731T3 (pl) 2019-04-30
SG182393A1 (en) 2012-08-30
JP2013517280A (ja) 2013-05-16
AU2011205290C1 (en) 2014-11-06
HRP20190064T1 (hr) 2019-03-08
RU2598708C2 (ru) 2016-09-27
SI2523731T1 (sl) 2019-02-28
JP6181610B2 (ja) 2017-08-16
LT2523731T (lt) 2019-02-11
HUS2000018I1 (hu) 2020-07-28
RU2012134510A (ru) 2014-02-20
CN102711916A (zh) 2012-10-03
JP2015013859A (ja) 2015-01-22

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