SK51052006A3 - Pyridínové deriváty alkyloxindolov ako aktívne látky voči 5-HT7 receptoru - Google Patents
Pyridínové deriváty alkyloxindolov ako aktívne látky voči 5-HT7 receptoru Download PDFInfo
- Publication number
- SK51052006A3 SK51052006A3 SK5105-2006A SK51052006A SK51052006A3 SK 51052006 A3 SK51052006 A3 SK 51052006A3 SK 51052006 A SK51052006 A SK 51052006A SK 51052006 A3 SK51052006 A3 SK 51052006A3
- Authority
- SK
- Slovakia
- Prior art keywords
- dihydro
- formula
- indol
- pharmaceutically acceptable
- acid addition
- Prior art date
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- 150000003222 pyridines Chemical class 0.000 title claims description 3
- 108091005436 5-HT7 receptors Proteins 0.000 title description 4
- 239000013543 active substance Substances 0.000 title description 2
- 150000005623 oxindoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 70
- -1 3,3-disubstituted indol-2-one Chemical class 0.000 claims abstract description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 15
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- 238000011321 prophylaxis Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 32
- 239000002253 acid Substances 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 150000002367 halogens Chemical class 0.000 claims description 14
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
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- 229910052736 halogen Inorganic materials 0.000 claims description 10
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- UKSQAJPCZKUHNI-UHFFFAOYSA-N 3-[4-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)butyl]-6-fluoro-1,3-dihydroindol-2-one Chemical compound O=C1NC2=CC(F)=CC=C2C1CCCCN(C1)CCC2=C1C=CS2 UKSQAJPCZKUHNI-UHFFFAOYSA-N 0.000 claims 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400956A HU0400956D0 (en) | 2004-05-11 | 2004-05-11 | Pyridine derivatives of alkyl oxindoles |
| HU0500462A HUP0500462A3 (en) | 2005-05-05 | 2005-05-05 | Pyridine derivatives of alkyloxindoles as 5ht7 receptor active agents |
| PCT/HU2005/000047 WO2005108388A1 (en) | 2004-05-11 | 2005-05-10 | Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK51052006A3 true SK51052006A3 (sk) | 2007-05-03 |
Family
ID=89985996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK5105-2006A SK51052006A3 (sk) | 2004-05-11 | 2005-05-10 | Pyridínové deriváty alkyloxindolov ako aktívne látky voči 5-HT7 receptoru |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20070265300A1 (bg) |
| EP (1) | EP1751134A1 (bg) |
| JP (1) | JP2007537225A (bg) |
| KR (1) | KR20070011552A (bg) |
| AU (1) | AU2005240841A1 (bg) |
| BG (1) | BG109767A (bg) |
| CA (1) | CA2565061A1 (bg) |
| CZ (1) | CZ2006769A3 (bg) |
| EA (1) | EA010154B1 (bg) |
| HR (1) | HRP20060402A2 (bg) |
| IL (1) | IL178891A0 (bg) |
| MX (1) | MXPA06012991A (bg) |
| NO (1) | NO20065696L (bg) |
| NZ (1) | NZ551543A (bg) |
| PL (1) | PL381612A1 (bg) |
| RS (1) | RS20060619A (bg) |
| SK (1) | SK51052006A3 (bg) |
| WO (1) | WO2005108388A1 (bg) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| EP3371168B1 (en) * | 2015-11-06 | 2020-05-27 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives |
| CN108137555B (zh) | 2015-11-06 | 2021-02-19 | 豪夫迈·罗氏有限公司 | 可用于治疗cns疾病的二氢吲哚-2-酮衍生物 |
| CN108349942B (zh) * | 2015-11-06 | 2021-03-30 | 豪夫迈·罗氏有限公司 | 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物 |
| EP3371174B1 (en) | 2015-11-06 | 2021-03-17 | H. Hoffnabb-La Roche Ag | Indolin-2-one derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| US6355642B1 (en) * | 1996-06-28 | 2002-03-12 | Meiji Seika Kaisha, Ltd. | Tetrahydrobenzindole compounds |
| WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| CA2316388C (en) * | 1997-12-25 | 2009-09-08 | Meiji Seika Kaisha Ltd. | Tetrahydrobenzindole derivative |
| JPH11189585A (ja) * | 1997-12-25 | 1999-07-13 | Meiji Seika Kaisha Ltd | ５−ｈｔ７受容体結合能を有するテトラヒドロベンズインドール誘導体 |
| EP1081136A4 (en) * | 1998-04-22 | 2002-07-03 | Meiji Seika Kaisha | OPTICALLY ACTIVE TETRAHYDROBENZINDOLES DERIVATIVES |
| JP2004231514A (ja) * | 2000-08-31 | 2004-08-19 | Meiji Seika Kaisha Ltd | ５−ｈｔ７受容体結合能を有し、かつ代謝的に安定なテトラヒドロベンズインドール誘導体 |
| AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
| AU2003257407A1 (en) * | 2002-08-29 | 2004-03-19 | H. Lundbeck A/S | S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
| ATE382045T1 (de) * | 2004-05-11 | 2008-01-15 | Egis Gyogyszergyar Nyrt | Indol-2-onderivate zur behandlung von erkrankungen des zentralen nervensystems, erkrankungen des magen-darm-trakts und herzkreislauferkankungen |
-
2005
- 2005-05-10 JP JP2007512355A patent/JP2007537225A/ja active Pending
- 2005-05-10 WO PCT/HU2005/000047 patent/WO2005108388A1/en active Application Filing
- 2005-05-10 NZ NZ551543A patent/NZ551543A/en unknown
- 2005-05-10 MX MXPA06012991A patent/MXPA06012991A/es not_active Application Discontinuation
- 2005-05-10 RS RSP-2006/0619A patent/RS20060619A/sr unknown
- 2005-05-10 CZ CZ20060769A patent/CZ2006769A3/cs unknown
- 2005-05-10 PL PL381612A patent/PL381612A1/pl not_active Application Discontinuation
- 2005-05-10 CA CA002565061A patent/CA2565061A1/en not_active Abandoned
- 2005-05-10 US US11/596,472 patent/US20070265300A1/en not_active Abandoned
- 2005-05-10 AU AU2005240841A patent/AU2005240841A1/en not_active Abandoned
- 2005-05-10 EA EA200602081A patent/EA010154B1/ru not_active IP Right Cessation
- 2005-05-10 SK SK5105-2006A patent/SK51052006A3/sk unknown
- 2005-05-10 EP EP05745441A patent/EP1751134A1/en not_active Withdrawn
- 2005-05-10 KR KR1020067025137A patent/KR20070011552A/ko not_active Application Discontinuation
-
2006
- 2006-10-26 IL IL178891A patent/IL178891A0/en unknown
- 2006-11-20 HR HR20060402A patent/HRP20060402A2/xx not_active Application Discontinuation
- 2006-12-11 NO NO20065696A patent/NO20065696L/no not_active Application Discontinuation
- 2006-12-11 BG BG109767A patent/BG109767A/bg unknown
-
2009
- 2009-07-28 US US12/510,872 patent/US20090306144A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005108388A1 (en) | 2005-11-17 |
| IL178891A0 (en) | 2007-03-08 |
| JP2007537225A (ja) | 2007-12-20 |
| NZ551543A (en) | 2009-12-24 |
| KR20070011552A (ko) | 2007-01-24 |
| EP1751134A1 (en) | 2007-02-14 |
| CA2565061A1 (en) | 2005-11-17 |
| US20070265300A1 (en) | 2007-11-15 |
| US20090306144A1 (en) | 2009-12-10 |
| MXPA06012991A (es) | 2007-05-04 |
| EA200602081A1 (ru) | 2007-04-27 |
| EA010154B1 (ru) | 2008-06-30 |
| HRP20060402A2 (en) | 2007-06-30 |
| NO20065696L (no) | 2007-02-08 |
| AU2005240841A1 (en) | 2005-11-17 |
| PL381612A1 (pl) | 2007-06-11 |
| CZ2006769A3 (cs) | 2007-03-14 |
| BG109767A (bg) | 2008-05-30 |
| RS20060619A (sr) | 2008-06-05 |
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