NO20065696L - Piperazinderivater av alkyloksindoler som 5-HT7 reseptoraktive midler. - Google Patents

Piperazinderivater av alkyloksindoler som 5-HT7 reseptoraktive midler.

Info

Publication number
NO20065696L
NO20065696L NO20065696A NO20065696A NO20065696L NO 20065696 L NO20065696 L NO 20065696L NO 20065696 A NO20065696 A NO 20065696A NO 20065696 A NO20065696 A NO 20065696A NO 20065696 L NO20065696 L NO 20065696L
Authority
NO
Norway
Prior art keywords
alkyloxindoles
active agents
piperazine derivatives
receptor active
derivatives
Prior art date
Application number
NO20065696A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Tibor Mezei
Gyula Simig
Balazs Volk
Dezsofi Rita Kapillerne
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0400956A external-priority patent/HU0400956D0/hu
Priority claimed from HU0500462A external-priority patent/HUP0500462A3/hu
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Publication of NO20065696L publication Critical patent/NO20065696L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det beskrives nye 3,3-disubstituerte indol-2-on-derivater med den generelle formel (I). Forbindelsene er nyttige for profilakse eller terapi av forstyrrelser i sentralnervesystemet.
NO20065696A 2004-05-11 2006-12-11 Piperazinderivater av alkyloksindoler som 5-HT7 reseptoraktive midler. NO20065696L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0400956A HU0400956D0 (en) 2004-05-11 2004-05-11 Pyridine derivatives of alkyl oxindoles
HU0500462A HUP0500462A3 (en) 2005-05-05 2005-05-05 Pyridine derivatives of alkyloxindoles as 5ht7 receptor active agents
PCT/HU2005/000047 WO2005108388A1 (en) 2004-05-11 2005-05-10 Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents

Publications (1)

Publication Number Publication Date
NO20065696L true NO20065696L (no) 2007-02-08

Family

ID=89985996

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065696A NO20065696L (no) 2004-05-11 2006-12-11 Piperazinderivater av alkyloksindoler som 5-HT7 reseptoraktive midler.

Country Status (18)

Country Link
US (2) US20070265300A1 (no)
EP (1) EP1751134A1 (no)
JP (1) JP2007537225A (no)
KR (1) KR20070011552A (no)
AU (1) AU2005240841A1 (no)
BG (1) BG109767A (no)
CA (1) CA2565061A1 (no)
CZ (1) CZ2006769A3 (no)
EA (1) EA010154B1 (no)
HR (1) HRP20060402A2 (no)
IL (1) IL178891A0 (no)
MX (1) MXPA06012991A (no)
NO (1) NO20065696L (no)
NZ (1) NZ551543A (no)
PL (1) PL381612A1 (no)
RS (1) RS20060619A (no)
SK (1) SK51052006A3 (no)
WO (1) WO2005108388A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
CN108137561B (zh) 2015-11-06 2021-03-26 豪夫迈·罗氏有限公司 二氢吲哚-2-酮衍生物
EP3371169B1 (en) 2015-11-06 2019-07-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
CN108349944B (zh) * 2015-11-06 2021-03-30 豪夫迈·罗氏有限公司 二氢吲哚-2-酮衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
EP0937715B1 (en) * 1996-06-28 2005-06-01 Meiji Seika Kaisha Ltd. Tetrahydrobenzindole compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
JPH11189585A (ja) * 1997-12-25 1999-07-13 Meiji Seika Kaisha Ltd ５−ｈｔ７受容体結合能を有するテトラヒドロベンズインドール誘導体
KR100588249B1 (ko) * 1997-12-25 2006-06-13 메이지 세이카 가부시키가이샤 테트라하이드로벤즈인돌 유도체
CN1168716C (zh) * 1998-04-22 2004-09-29 明治制果株式会社 光学活性四氢苯并吲哚衍生物
JP2004231514A (ja) * 2000-08-31 2004-08-19 Meiji Seika Kaisha Ltd ５−ｈｔ７受容体結合能を有し、かつ代謝的に安定なテトラヒドロベンズインドール誘導体
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
RS20060622A (en) * 2004-05-11 2008-06-05 Egis Gyogyszergyar Nyrt., Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders

Also Published As

Publication number Publication date
JP2007537225A (ja) 2007-12-20
RS20060619A (sr) 2008-06-05
US20070265300A1 (en) 2007-11-15
CZ2006769A3 (cs) 2007-03-14
AU2005240841A1 (en) 2005-11-17
KR20070011552A (ko) 2007-01-24
US20090306144A1 (en) 2009-12-10
NZ551543A (en) 2009-12-24
IL178891A0 (en) 2007-03-08
HRP20060402A2 (en) 2007-06-30
EA200602081A1 (ru) 2007-04-27
BG109767A (bg) 2008-05-30
EP1751134A1 (en) 2007-02-14
WO2005108388A1 (en) 2005-11-17
CA2565061A1 (en) 2005-11-17
EA010154B1 (ru) 2008-06-30
SK51052006A3 (sk) 2007-05-03
MXPA06012991A (es) 2007-05-04
PL381612A1 (pl) 2007-06-11

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