SK490689A3 - Peptides having antagonizing bradykinin effects and method of producing said peptides - Google Patents
Peptides having antagonizing bradykinin effects and method of producing said peptides Download PDFInfo
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- SK490689A3 SK490689A3 SK4906-89A SK490689A SK490689A3 SK 490689 A3 SK490689 A3 SK 490689A3 SK 490689 A SK490689 A SK 490689A SK 490689 A3 SK490689 A3 SK 490689A3
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 82
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 27
- 101800004538 Bradykinin Proteins 0.000 title claims abstract description 13
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- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title claims abstract description 13
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3839581 | 1988-11-24 | ||
| DE3916291 | 1989-05-19 | ||
| DE3918225 | 1989-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK279315B6 SK279315B6 (sk) | 1998-09-09 |
| SK490689A3 true SK490689A3 (en) | 1998-09-09 |
Family
ID=27198531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK4906-89A SK490689A3 (en) | 1988-11-24 | 1989-08-21 | Peptides having antagonizing bradykinin effects and method of producing said peptides |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0370453B1 (xx) |
| JP (1) | JPH07121956B2 (xx) |
| KR (1) | KR0139632B1 (xx) |
| CN (1) | CN1035006C (xx) |
| AT (1) | ATE107318T1 (xx) |
| AU (1) | AU612054B2 (xx) |
| CA (1) | CA1340667C (xx) |
| CY (2) | CY2028A (xx) |
| CZ (1) | CZ282384B6 (xx) |
| DE (3) | DE122008000066I2 (xx) |
| DK (1) | DK175344B1 (xx) |
| ES (1) | ES2057071T3 (xx) |
| FI (1) | FI94353C (xx) |
| HK (1) | HK1006716A1 (xx) |
| HU (2) | HU210566B (xx) |
| IE (1) | IE63490B1 (xx) |
| IL (1) | IL91298A (xx) |
| LU (1) | LU91499I2 (xx) |
| LV (1) | LV10720B (xx) |
| MX (1) | MX9203277A (xx) |
| NL (1) | NL300359I2 (xx) |
| NO (2) | NO177597C (xx) |
| NZ (1) | NZ230244A (xx) |
| PH (1) | PH31009A (xx) |
| PT (1) | PT91692B (xx) |
| SK (1) | SK490689A3 (xx) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4013270A1 (de) * | 1990-04-26 | 1991-10-31 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
| US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
| DE69012142D1 (de) * | 1989-12-08 | 1994-10-06 | Univ Boston | Acylierte bradykininantagonisten und deren verwendung. |
| MX9100717A (es) * | 1990-08-24 | 1992-04-01 | Syntex Inc | Antagonistas de la bradiquinina |
| US5416191A (en) * | 1991-04-01 | 1995-05-16 | Cortech, Inc. | Bradykinin antagonists |
| US5843900A (en) * | 1991-04-01 | 1998-12-01 | Cortech, Inc. | Bradykinin antagonists |
| US6770741B1 (en) | 1991-04-19 | 2004-08-03 | Scios Inc. | Bradykinin antagonist peptides |
| WO1992018155A1 (en) * | 1991-04-19 | 1992-10-29 | Nova Technology Limited Partnership | Bradykinin type peptides |
| WO1992018156A1 (en) * | 1991-04-19 | 1992-10-29 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| HUT63060A (en) * | 1991-08-22 | 1993-07-28 | Hoechst Ag | Process for producing pharmaceutical compositions locally applicable on nose and eye, comprising bradykinin antagonists |
| US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
| WO1993011789A1 (en) * | 1991-12-12 | 1993-06-24 | Scios Nova Inc. | Modified position (7) bradykinin antagonist peptides |
| TW199863B (xx) * | 1991-12-21 | 1993-02-11 | Hoechst Ag | |
| WO1993017701A1 (en) * | 1992-03-12 | 1993-09-16 | The Administrators Of The Tulane Educational Fund | Endothelin receptor-binding peptides |
| TW258739B (xx) * | 1992-04-04 | 1995-10-01 | Hoechst Ag | |
| FR2692581B1 (fr) * | 1992-06-18 | 1994-08-19 | Adir | Nouveaux dérivés peptidiques à activité antagoniste de la bradykinine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US5686565A (en) * | 1992-10-08 | 1997-11-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins |
| US5610142A (en) * | 1992-10-08 | 1997-03-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids |
| US5541286A (en) * | 1992-10-08 | 1996-07-30 | Scios Nova Inc. | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids |
| US5521158A (en) * | 1992-10-08 | 1996-05-28 | Scios Nova Inc. | Pseudopeptide bradykinin receptor antagonists |
| IL107400A0 (en) * | 1992-11-10 | 1994-01-25 | Cortech Inc | Bradykinin antagonists |
| WO1994019372A1 (en) * | 1993-02-17 | 1994-09-01 | Scios Nova Inc. | Cyclic bradykinin antagonist peptides |
| US5817756A (en) * | 1993-09-09 | 1998-10-06 | Scios Inc. | Pseudo- and non-peptide bradykinin receptor antagonists |
| DE4345062A1 (de) * | 1993-12-31 | 1995-07-13 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen |
| EP0813544B1 (en) * | 1994-03-09 | 2004-10-27 | Cortech, Inc. | Bradykinin antagonist peptides incorporating n-substituted glycines |
| US6407059B1 (en) | 1994-06-08 | 2002-06-18 | Peptor Limited | Conformationally constrained backbone cyclized peptide analogs |
| IL109943A (en) | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
| WO1996039425A2 (en) * | 1995-06-05 | 1996-12-12 | Cortech, Inc. | Compounds having bradykinin antagonistic activity and mu-opioid agonistic activity |
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| US6051554A (en) * | 1995-06-07 | 2000-04-18 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| FR2737408B1 (fr) * | 1995-07-31 | 1997-09-05 | Oreal | Utilisation d'un antagoniste de bradykinine dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue |
| US5834431A (en) * | 1995-09-08 | 1998-11-10 | Cortech, Inc. | Des-Arg9 -BK antagonists |
| US5849863A (en) * | 1995-09-08 | 1998-12-15 | University Of Colorado | Cytolytic bradykinin antagonists |
| FR2739553B1 (fr) | 1995-10-06 | 1998-01-02 | Oreal | Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
| US6841533B1 (en) | 1995-12-07 | 2005-01-11 | Peptor Limited | Conformationally constrained backbone cyclized interleukin-6 antagonists |
| DE19612067A1 (de) * | 1996-03-27 | 1997-10-02 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
| US6355613B1 (en) | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| DE19642289A1 (de) | 1996-10-14 | 1998-04-16 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit |
| DE10304994A1 (de) * | 2003-02-07 | 2004-09-02 | Aventis Pharma Deutschland Gmbh | Die Verwendung von Antagonisten des Bradykinin-B2 Rezeptors zur Behandlung von Osteoarthrose |
| CN102532267B (zh) * | 2012-02-09 | 2014-06-18 | 深圳翰宇药业股份有限公司 | 一种艾替班特的制备方法 |
| CN104043101B (zh) * | 2014-05-23 | 2016-04-20 | 杭州阿德莱诺泰制药技术有限公司 | 一种艾替班特注射用组合物及其制备方法和制剂 |
| KR102099509B1 (ko) | 2018-07-27 | 2020-04-09 | 강경순 | 과수용 받침지주 |
| CN111944016B (zh) * | 2020-08-25 | 2022-04-29 | 台州吉诺生物科技有限公司 | 一种醋酸艾替班特的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3044236A1 (de) * | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| DE3227055A1 (de) * | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
| FR2575753B1 (fr) * | 1985-01-07 | 1987-02-20 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US4693993A (en) * | 1985-06-13 | 1987-09-15 | Stewart John M | Bradykinin antagonist peptides |
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1989
- 1989-08-03 IE IE252289A patent/IE63490B1/en not_active IP Right Cessation
- 1989-08-04 DK DK198903840A patent/DK175344B1/da active Protection Beyond IP Right Term
- 1989-08-08 FI FI893738A patent/FI94353C/fi active Protection Beyond IP Right Term
- 1989-08-08 NZ NZ230244A patent/NZ230244A/en unknown
- 1989-08-08 NO NO893193A patent/NO177597C/no not_active IP Right Cessation
- 1989-08-09 CA CA000607853A patent/CA1340667C/en not_active Expired - Lifetime
- 1989-08-09 AU AU39431/89A patent/AU612054B2/en not_active Expired
- 1989-08-11 IL IL9129889A patent/IL91298A/en unknown
- 1989-08-21 CZ CS894906A patent/CZ282384B6/cs not_active IP Right Cessation
- 1989-08-21 SK SK4906-89A patent/SK490689A3/sk unknown
- 1989-08-23 HU HU894323A patent/HU210566B/hu unknown
- 1989-08-28 JP JP1218758A patent/JPH07121956B2/ja not_active Expired - Lifetime
- 1989-09-11 KR KR1019890013102A patent/KR0139632B1/ko not_active IP Right Cessation
- 1989-09-11 CN CN89107065A patent/CN1035006C/zh not_active Expired - Lifetime
- 1989-09-11 PT PT91692A patent/PT91692B/pt not_active IP Right Cessation
- 1989-11-21 DE DE122008000066C patent/DE122008000066I2/de active Active
- 1989-11-21 DE DE58907889T patent/DE58907889D1/de not_active Expired - Lifetime
- 1989-11-21 AT AT89121498T patent/ATE107318T1/de active
- 1989-11-21 DE DE3938751A patent/DE3938751A1/de not_active Withdrawn
- 1989-11-21 ES ES89121498T patent/ES2057071T3/es not_active Expired - Lifetime
- 1989-11-21 EP EP89121498A patent/EP0370453B1/de not_active Expired - Lifetime
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1990
- 1990-07-30 PH PH40920A patent/PH31009A/en unknown
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1992
- 1992-06-24 MX MX9203277A patent/MX9203277A/es active IP Right Grant
- 1992-12-23 LV LVP-92-701A patent/LV10720B/en unknown
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1995
- 1995-01-20 HU HU95P/P00069P patent/HU210712A9/hu active Protection Beyond IP Right Term
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1998
- 1998-02-20 CY CY202898A patent/CY2028A/xx unknown
- 1998-06-22 HK HK98105867A patent/HK1006716A1/xx not_active IP Right Cessation
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2008
- 2008-09-09 NL NL300359C patent/NL300359I2/nl unknown
- 2008-10-30 NO NO2008016C patent/NO2008016I2/no unknown
- 2008-11-19 LU LU91499C patent/LU91499I2/xx unknown
- 2008-12-30 CY CY200800022C patent/CY2008022I1/el unknown
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