SK4742001A3 - Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection - Google Patents
Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection Download PDFInfo
- Publication number
- SK4742001A3 SK4742001A3 SK474-2001A SK4742001A SK4742001A3 SK 4742001 A3 SK4742001 A3 SK 4742001A3 SK 4742001 A SK4742001 A SK 4742001A SK 4742001 A3 SK4742001 A3 SK 4742001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- effective amount
- interferon alpha
- represented
- Prior art date
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- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
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- 229940006959 ribavirin 500 mg Drugs 0.000 description 1
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical compound OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- XYITYKDGJLHYPW-UHFFFAOYSA-M sodium 2-iodohippurate Chemical compound [Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1I XYITYKDGJLHYPW-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17405998A | 1998-10-16 | 1998-10-16 | |
| US09/348,534 US6277830B1 (en) | 1998-10-16 | 1999-07-07 | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
| PCT/US1999/021448 WO2000023454A1 (en) | 1998-10-16 | 1999-10-14 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK4742001A3 true SK4742001A3 (en) | 2001-11-06 |
Family
ID=26869824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK474-2001A SK4742001A3 (en) | 1998-10-16 | 1999-10-14 | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1121369B1 (cs) |
| JP (1) | JP2002527522A (cs) |
| CN (1) | CN1330658A (cs) |
| AT (1) | ATE284408T1 (cs) |
| AU (1) | AU762395B2 (cs) |
| BR (1) | BR9915546A (cs) |
| CA (1) | CA2346447C (cs) |
| CZ (1) | CZ20011130A3 (cs) |
| DE (1) | DE69922529T2 (cs) |
| ES (1) | ES2229820T3 (cs) |
| HU (1) | HUP0200447A2 (cs) |
| ID (1) | ID29187A (cs) |
| IL (1) | IL142423A0 (cs) |
| NO (1) | NO20011789L (cs) |
| NZ (1) | NZ510811A (cs) |
| PL (1) | PL347268A1 (cs) |
| RU (1) | RU2001113268A (cs) |
| SK (1) | SK4742001A3 (cs) |
| TR (1) | TR200101085T2 (cs) |
| WO (1) | WO2000023454A1 (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924270B2 (en) * | 2000-04-20 | 2005-08-02 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| MXPA05010419A (es) * | 2003-03-28 | 2006-05-31 | Pharmasset Inc | Compuestos para el tratamiento de infecciones por flaviviridae. |
| ZA200601181B (en) * | 2003-08-13 | 2007-04-25 | Smith Howard J & Ass Pty Ltd | Method of treating viral infections |
| US7410979B2 (en) | 2003-11-19 | 2008-08-12 | Rigel Pharmaceuticals, Inc. | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections |
| WO2007027230A2 (en) | 2005-05-02 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| JPWO2009028575A1 (ja) | 2007-08-27 | 2010-12-02 | 国立大学法人名古屋大学 | 血液凝固第ｖｉｉ因子プロモーターの活性化剤及びその利用 |
| EP2201953A4 (en) | 2007-08-27 | 2011-08-03 | Univ Nagoya Nat Univ Corp | USE OF RIBAVIRIN IN BLOOD CLEANING DISORDERS |
| WO2011151667A1 (en) | 2010-06-02 | 2011-12-08 | Adbula Kurkayev | Antiviral compositions |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| MX2014004729A (es) | 2011-10-21 | 2014-07-28 | Abbvie Inc | Tratamiento en combinacion (por ejemplo, con abt-072 o abt-333) de agentes antivirales de accion directa para utilizarse en el tratamiento del virus de la hepatitis c. |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
| WO2018035380A1 (en) | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| CN107513055B (zh) * | 2017-08-11 | 2018-06-22 | 广东昊邦医药健康有限责任公司 | 一种利巴韦林衍生化合物及其药物组合物 |
| US20240325419A1 (en) | 2022-05-05 | 2024-10-03 | Abdula Kurkayev | Pharmaceutical composition for restoring physiological processes and cells of organism |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1482736A (en) * | 1974-03-18 | 1977-08-10 | Icn Pharmaceuticals | 1-(beta-d-ribofuranosyl)-1,2,4-triazole acid derivatives |
| US4544741A (en) * | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
| US4925930A (en) * | 1988-11-02 | 1990-05-15 | Nucleic Acid Research Institute | Synthesis and anti-leukemic activity of alkyl-1-(β-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates |
| GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
| US6387365B1 (en) * | 1995-05-19 | 2002-05-14 | Schering Corporation | Combination therapy for chronic hepatitis C infection |
| WO1998021223A1 (en) * | 1996-11-12 | 1998-05-22 | Medivir Ab | Nucleosides |
-
1999
- 1999-10-14 ID IDW20010844A patent/ID29187A/id unknown
- 1999-10-14 NZ NZ510811A patent/NZ510811A/xx unknown
- 1999-10-14 RU RU2001113268/04A patent/RU2001113268A/ru not_active Application Discontinuation
- 1999-10-14 WO PCT/US1999/021448 patent/WO2000023454A1/en active IP Right Grant
- 1999-10-14 JP JP2000577180A patent/JP2002527522A/ja active Pending
- 1999-10-14 DE DE69922529T patent/DE69922529T2/de not_active Expired - Fee Related
- 1999-10-14 PL PL99347268A patent/PL347268A1/xx not_active Application Discontinuation
- 1999-10-14 ES ES99970662T patent/ES2229820T3/es not_active Expired - Lifetime
- 1999-10-14 IL IL14242399A patent/IL142423A0/xx unknown
- 1999-10-14 SK SK474-2001A patent/SK4742001A3/sk unknown
- 1999-10-14 CN CN99814344A patent/CN1330658A/zh active Pending
- 1999-10-14 BR BR9915546-0A patent/BR9915546A/pt not_active IP Right Cessation
- 1999-10-14 AT AT99970662T patent/ATE284408T1/de not_active IP Right Cessation
- 1999-10-14 CA CA002346447A patent/CA2346447C/en not_active Expired - Fee Related
- 1999-10-14 EP EP99970662A patent/EP1121369B1/en not_active Expired - Lifetime
- 1999-10-14 CZ CZ20011130A patent/CZ20011130A3/cs unknown
- 1999-10-14 AU AU11975/00A patent/AU762395B2/en not_active Ceased
- 1999-10-14 HU HU0200447A patent/HUP0200447A2/hu unknown
- 1999-10-14 TR TR2001/01085T patent/TR200101085T2/xx unknown
-
2001
- 2001-04-09 NO NO20011789A patent/NO20011789L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69922529T2 (de) | 2005-12-15 |
| NZ510811A (en) | 2003-06-30 |
| NO20011789L (no) | 2001-06-11 |
| AU762395B2 (en) | 2003-06-26 |
| CA2346447C (en) | 2006-01-31 |
| EP1121369A1 (en) | 2001-08-08 |
| DE69922529D1 (de) | 2005-01-13 |
| EP1121369B1 (en) | 2004-12-08 |
| CZ20011130A3 (cs) | 2001-08-15 |
| IL142423A0 (en) | 2002-03-10 |
| ES2229820T3 (es) | 2005-04-16 |
| ID29187A (id) | 2001-08-09 |
| JP2002527522A (ja) | 2002-08-27 |
| HUP0200447A2 (en) | 2002-06-29 |
| AU1197500A (en) | 2000-05-08 |
| CN1330658A (zh) | 2002-01-09 |
| PL347268A1 (en) | 2002-03-25 |
| RU2001113268A (ru) | 2003-09-27 |
| BR9915546A (pt) | 2001-08-14 |
| CA2346447A1 (en) | 2000-04-27 |
| ATE284408T1 (de) | 2004-12-15 |
| WO2000023454A1 (en) | 2000-04-27 |
| NO20011789D0 (no) | 2001-04-09 |
| TR200101085T2 (tr) | 2001-08-21 |
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