SK4722000A3 - Methods of in vitro modulating serine/threonine protein kinase function, identification method of corresponding modulators, of 5-azaquinoxaline-based compounds, method for the production thereof and pharmaceutical compositions - Google Patents

Methods of in vitro modulating serine/threonine protein kinase function, identification method of corresponding modulators, of 5-azaquinoxaline-based compounds, method for the production thereof and pharmaceutical compositions Download PDF

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Publication number
SK4722000A3
SK4722000A3 SK472-2000A SK4722000A SK4722000A3 SK 4722000 A3 SK4722000 A3 SK 4722000A3 SK 4722000 A SK4722000 A SK 4722000A SK 4722000 A3 SK4722000 A3 SK 4722000A3
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SK
Slovakia
Prior art keywords
group
independently selected
alkyl
compound
formula
Prior art date
Application number
SK472-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Gerald Mcmahon
Bernhard Kutscher
Eckhard Gunther
Harald App
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of SK4722000A3 publication Critical patent/SK4722000A3/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK472-2000A 1997-10-06 1998-10-05 Methods of in vitro modulating serine/threonine protein kinase function, identification method of corresponding modulators, of 5-azaquinoxaline-based compounds, method for the production thereof and pharmaceutical compositions SK4722000A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6112397P 1997-10-06 1997-10-06
PCT/US1998/020910 WO1999017759A2 (en) 1997-10-06 1998-10-05 Methods of modulating serine/threonine protein kinase function with 5-azaquinoxaline-based compounds

Publications (1)

Publication Number Publication Date
SK4722000A3 true SK4722000A3 (en) 2002-06-04

Family

ID=22033733

Family Applications (1)

Application Number Title Priority Date Filing Date
SK472-2000A SK4722000A3 (en) 1997-10-06 1998-10-05 Methods of in vitro modulating serine/threonine protein kinase function, identification method of corresponding modulators, of 5-azaquinoxaline-based compounds, method for the production thereof and pharmaceutical compositions

Country Status (31)

Country Link
US (2) US6180631B1 (pt)
EP (1) EP1028729B1 (pt)
JP (1) JP2001518496A (pt)
KR (1) KR100633270B1 (pt)
CN (1) CN1169527C (pt)
AR (1) AR013542A1 (pt)
AT (1) ATE336250T1 (pt)
AU (1) AU757585B2 (pt)
BG (1) BG64969B1 (pt)
BR (1) BR9814814A (pt)
CA (1) CA2306257C (pt)
CY (1) CY1106223T1 (pt)
CZ (1) CZ298775B6 (pt)
DE (1) DE69835612T2 (pt)
DK (1) DK1028729T3 (pt)
ES (1) ES2268791T3 (pt)
HK (1) HK1031836A1 (pt)
HU (1) HUP0100302A3 (pt)
IL (2) IL135103A0 (pt)
MX (1) MXPA03011007A (pt)
NO (1) NO316598B1 (pt)
NZ (1) NZ503431A (pt)
PL (1) PL192039B1 (pt)
PT (1) PT1028729E (pt)
RU (1) RU2223753C2 (pt)
SK (1) SK4722000A3 (pt)
TR (2) TR200000906T2 (pt)
TW (1) TWI245765B (pt)
UA (1) UA71555C2 (pt)
WO (1) WO1999017759A2 (pt)
ZA (1) ZA988961B (pt)

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ATE556713T1 (de) * 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
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US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
AU2003209116A1 (en) * 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2004027361A1 (en) * 2002-09-17 2004-04-01 University Of Virginia Patent Foundation Remote temperature sensing of small volume and related apparatus thereof
US7557129B2 (en) * 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
PT1636585E (pt) * 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
DE10323345A1 (de) 2003-05-23 2004-12-16 Zentaris Gmbh Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
DE102004022383A1 (de) * 2004-05-06 2005-12-01 Zentaris Gmbh Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen
EP1636228B1 (de) * 2003-05-23 2008-10-22 AEterna Zentaris GmbH Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
US20060293340A1 (en) * 2003-06-13 2006-12-28 Novartis Ag 2-Aminopyrimidine derivatives as raf kinase inhibitors
JP4777887B2 (ja) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション 病気および状態の処置および防止のためのフロロ置換オメガカルボキシアリールジフェニル尿素
CA2628039A1 (en) * 2005-11-11 2007-05-18 Aeterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
WO2010003308A1 (zh) * 2008-07-10 2010-01-14 卞化石 一氧化氮及其信息传递系统在制备恶性肿瘤靶向治疗药物中的应用
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GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
GB201118656D0 (en) * 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
WO2014109414A1 (ja) * 2013-01-11 2014-07-17 富士フイルム株式会社 含窒素複素環化合物またはその塩
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
DE102013008118A1 (de) * 2013-05-11 2014-11-13 Merck Patent Gmbh Arylchinazoline
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
HUE053653T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR inhibitor és IGF1R inhibitor kombinációi
EP3848034A1 (en) 2014-03-26 2021-07-14 Astex Therapeutics Limited Cmet-inhibitors for use in delaying the emergence in resistance to fgfr inhibitors
MY187540A (en) 2014-08-01 2021-09-28 Nuevolution As Compounds active towards bromodomains
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
CN108137546B (zh) 2015-09-23 2021-07-27 詹森药业有限公司 双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途
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Also Published As

Publication number Publication date
DE69835612D1 (de) 2006-09-28
HUP0100302A2 (hu) 2001-06-28
CA2306257A1 (en) 1999-04-15
US6180631B1 (en) 2001-01-30
DK1028729T3 (da) 2006-12-11
DE69835612T2 (de) 2007-08-16
CN1274284A (zh) 2000-11-22
BG104392A (en) 2000-12-29
PL339860A1 (en) 2001-01-15
EP1028729B1 (en) 2006-08-16
ES2268791T3 (es) 2007-03-16
BG64969B1 (bg) 2006-11-30
AR013542A1 (es) 2000-12-27
NO20001748L (no) 2000-04-05
HUP0100302A3 (en) 2006-03-28
CY1106223T1 (el) 2011-06-08
IL135103A0 (en) 2001-05-20
AU757585B2 (en) 2003-02-27
MXPA03011007A (es) 2004-02-27
UA71555C2 (en) 2004-12-15
BR9814814A (pt) 2000-10-03
WO1999017759A3 (en) 2000-01-06
EP1028729A2 (en) 2000-08-23
JP2001518496A (ja) 2001-10-16
CZ20001129A3 (cs) 2000-10-11
AU9514198A (en) 1999-04-27
NO20001748D0 (no) 2000-04-05
NO316598B1 (no) 2004-03-01
US6727252B1 (en) 2004-04-27
ZA988961B (en) 1999-10-04
PL192039B1 (pl) 2006-08-31
CA2306257C (en) 2007-09-25
TWI245765B (en) 2005-12-21
ATE336250T1 (de) 2006-09-15
TR200100385T2 (tr) 2002-06-21
KR20010030934A (ko) 2001-04-16
CZ298775B6 (cs) 2008-01-23
PT1028729E (pt) 2006-12-29
RU2223753C2 (ru) 2004-02-20
KR100633270B1 (ko) 2006-10-16
NZ503431A (en) 2002-07-26
HK1031836A1 (en) 2001-06-29
WO1999017759A2 (en) 1999-04-15
CN1169527C (zh) 2004-10-06
TR200000906T2 (tr) 2000-11-21
IL135103A (en) 2007-06-17

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