SK288094B6 - Protein product based on truncated neurotrophic factor, polynucleotide encoding this protein product, vector comprising such polynucleotide, prokaryotic or eukaryotic host cell transformed or transfected with such polynucleotide, process for obtaining said protein product, pharmaceutical composition comprising the protein product, process for preparing this composition and use said product - Google Patents
Protein product based on truncated neurotrophic factor, polynucleotide encoding this protein product, vector comprising such polynucleotide, prokaryotic or eukaryotic host cell transformed or transfected with such polynucleotide, process for obtaining said protein product, pharmaceutical composition comprising the protein product, process for preparing this composition and use said product Download PDFInfo
- Publication number
- SK288094B6 SK288094B6 SK389-98A SK38998A SK288094B6 SK 288094 B6 SK288094 B6 SK 288094B6 SK 38998 A SK38998 A SK 38998A SK 288094 B6 SK288094 B6 SK 288094B6
- Authority
- SK
- Slovakia
- Prior art keywords
- gdnf
- protein
- arg
- engineered
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/535,681 US6184200B1 (en) | 1995-09-28 | 1995-09-28 | Truncated glial cell line-derived neurotrophic factor |
PCT/US1996/014915 WO1997011964A1 (en) | 1995-09-28 | 1996-09-16 | Truncated glial cell line-derived neurotrophic factor |
Publications (2)
Publication Number | Publication Date |
---|---|
SK38998A3 SK38998A3 (en) | 1999-07-12 |
SK288094B6 true SK288094B6 (sk) | 2013-07-02 |
Family
ID=24135310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK389-98A SK288094B6 (sk) | 1995-09-28 | 1996-09-16 | Protein product based on truncated neurotrophic factor, polynucleotide encoding this protein product, vector comprising such polynucleotide, prokaryotic or eukaryotic host cell transformed or transfected with such polynucleotide, process for obtaining said protein product, pharmaceutical composition comprising the protein product, process for preparing this composition and use said product |
Country Status (25)
Country | Link |
---|---|
US (5) | US6184200B1 (cs) |
EP (1) | EP0920448B1 (cs) |
JP (3) | JP4153036B2 (cs) |
KR (1) | KR100334739B1 (cs) |
CN (1) | CN1283659C (cs) |
AT (1) | ATE314389T1 (cs) |
AU (1) | AU707528B2 (cs) |
CA (1) | CA2232749C (cs) |
CZ (1) | CZ297326B6 (cs) |
DE (1) | DE69635675T2 (cs) |
DK (1) | DK0920448T3 (cs) |
EA (1) | EA001204B1 (cs) |
ES (1) | ES2255713T3 (cs) |
HK (1) | HK1021823A1 (cs) |
HU (1) | HU226220B1 (cs) |
IL (6) | IL144488A0 (cs) |
MX (1) | MX9802278A (cs) |
NO (1) | NO322521B1 (cs) |
NZ (1) | NZ318697A (cs) |
SI (1) | SI0920448T1 (cs) |
SK (1) | SK288094B6 (cs) |
TW (1) | TW570926B (cs) |
UA (1) | UA66339C2 (cs) |
WO (1) | WO1997011964A1 (cs) |
ZA (1) | ZA968087B (cs) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
DE19816186A1 (de) * | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
US20020055467A1 (en) * | 1998-07-06 | 2002-05-09 | Johansen Teit E. | Novel neurotrophic factors |
US6507788B1 (en) * | 1999-02-25 | 2003-01-14 | Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) | Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function |
US6897061B1 (en) * | 2000-06-16 | 2005-05-24 | Spinal Cord Society | Transdifferentiation of glial cells |
US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7276580B2 (en) | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
US7245117B1 (en) | 2004-11-01 | 2007-07-17 | Cardiomems, Inc. | Communicating with implanted wireless sensor |
US20060239966A1 (en) * | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
JP2007509109A (ja) | 2003-10-20 | 2007-04-12 | エヌエスジーン・アクティーゼルスカブ | パーキンソン病のインビボ遺伝子治療 |
AU2005277227B2 (en) | 2004-08-19 | 2011-10-06 | Biogen Ma Inc. | Refolding transforming growth factor beta family proteins |
TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
EP2054074B8 (en) * | 2006-08-04 | 2014-11-12 | Prolong Pharmaceuticals, LLC | Modified erythropoietin |
WO2008100966A1 (en) * | 2007-02-12 | 2008-08-21 | The Research Foundation Of State University Of New York | Gdnf-derived peptides |
JP5583005B2 (ja) | 2007-05-01 | 2014-09-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血管新生を増大させるための組成物および方法 |
US8446454B2 (en) * | 2007-05-21 | 2013-05-21 | Polycom, Inc. | Dynamic adaption of a continuous presence videoconferencing layout based on video content |
FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
UA112981C2 (uk) | 2011-04-11 | 2016-11-25 | Елі Ліллі Енд Компані | Варіант людського gdnf |
US10376562B2 (en) | 2013-03-15 | 2019-08-13 | The Jackson Laboratory | Methods for promoting wound healing and hair growth comprising GDNF administration |
RU2561050C2 (ru) | 2013-08-28 | 2015-08-20 | Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) | Применение белка yb-1 и его фрагментов для изготовления лекарственных средств при лечении болезни альцгеймера |
AU2017357931A1 (en) | 2016-11-10 | 2019-06-20 | Keros Therapeutics, Inc. | GDNF fusion polypeptides and methods of use thereof |
JP2023515915A (ja) * | 2019-12-19 | 2023-04-17 | トランスフェルト・プラス・ソシエテ・アン・コマンディテ | 腸のニューロパチーを治療するためのグリア細胞株由来神経栄養因子(gdnf)の使用 |
TW202325850A (zh) | 2021-11-29 | 2023-07-01 | 大陸商上海瑞宏迪醫藥有限公司 | Aadc、gdnf多核苷酸及其用於治療帕金森病 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
US5229500A (en) | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
CA1332433C (en) | 1989-09-29 | 1994-10-11 | Robert L. Sutherland | Ski structure and binding therefor |
ATE194651T1 (de) | 1989-10-16 | 2000-07-15 | Amgen Inc | Stammzellenfaktor |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
WO1991010470A1 (en) | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
US5202428A (en) | 1990-06-20 | 1993-04-13 | The Salk Institute For Biological Studies | DNA encoding neurotropic growth factor |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
GEP20002243B (en) | 1991-09-20 | 2000-09-25 | Amgen Inc | Glial Derived Neurotrophic Factor |
WO1995017203A1 (en) | 1993-12-22 | 1995-06-29 | The University Of Medicine And Dentistry Of New Jersey | Novel nucleic acid sequences isolated from glial cells |
FR2717824B1 (fr) * | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
US5733875A (en) * | 1994-11-15 | 1998-03-31 | Amgen Inc. | Methods of using GDNF as a neuroprotective agent |
US5739307A (en) | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
US5731284A (en) * | 1995-09-28 | 1998-03-24 | Amgen Inc. | Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product |
US6184200B1 (en) | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
US5929041A (en) * | 1996-02-23 | 1999-07-27 | Amgen Inc. | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
US5837681A (en) * | 1996-02-23 | 1998-11-17 | Amgen Inc. | Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product |
US5741778A (en) * | 1996-03-19 | 1998-04-21 | Amgen Inc. | Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product |
-
1995
- 1995-09-28 US US08/535,681 patent/US6184200B1/en not_active Expired - Lifetime
-
1996
- 1996-09-16 AT AT96931618T patent/ATE314389T1/de active
- 1996-09-16 IL IL14448896A patent/IL144488A0/xx active IP Right Grant
- 1996-09-16 SI SI9630726T patent/SI0920448T1/sl unknown
- 1996-09-16 CN CNB961972335A patent/CN1283659C/zh not_active Expired - Fee Related
- 1996-09-16 UA UA98031545A patent/UA66339C2/uk unknown
- 1996-09-16 IL IL12376196A patent/IL123761A/en not_active IP Right Cessation
- 1996-09-16 DK DK96931618T patent/DK0920448T3/da active
- 1996-09-16 NZ NZ318697A patent/NZ318697A/en not_active IP Right Cessation
- 1996-09-16 CZ CZ0088298A patent/CZ297326B6/cs not_active IP Right Cessation
- 1996-09-16 AU AU70746/96A patent/AU707528B2/en not_active Ceased
- 1996-09-16 EP EP96931618A patent/EP0920448B1/en not_active Expired - Lifetime
- 1996-09-16 ES ES96931618T patent/ES2255713T3/es not_active Expired - Lifetime
- 1996-09-16 SK SK389-98A patent/SK288094B6/sk not_active IP Right Cessation
- 1996-09-16 IL IL14401896A patent/IL144018A0/xx unknown
- 1996-09-16 DE DE69635675T patent/DE69635675T2/de not_active Expired - Lifetime
- 1996-09-16 CA CA002232749A patent/CA2232749C/en not_active Expired - Fee Related
- 1996-09-16 EA EA199800301A patent/EA001204B1/ru not_active IP Right Cessation
- 1996-09-16 WO PCT/US1996/014915 patent/WO1997011964A1/en active Application Filing
- 1996-09-16 HU HU9802262A patent/HU226220B1/hu not_active IP Right Cessation
- 1996-09-16 JP JP51349497A patent/JP4153036B2/ja not_active Expired - Fee Related
- 1996-09-16 KR KR1019980702293A patent/KR100334739B1/ko not_active IP Right Cessation
- 1996-09-26 TW TW085111819A patent/TW570926B/zh not_active IP Right Cessation
- 1996-09-26 ZA ZA968087A patent/ZA968087B/xx unknown
-
1998
- 1998-03-23 MX MX9802278A patent/MX9802278A/es active IP Right Grant
- 1998-03-30 NO NO19981430A patent/NO322521B1/no not_active IP Right Cessation
-
1999
- 1999-12-09 HK HK99105788A patent/HK1021823A1/xx not_active IP Right Cessation
-
2001
- 2001-06-26 IL IL144018A patent/IL144018A/en not_active IP Right Cessation
- 2001-07-23 IL IL144488A patent/IL144488A/en not_active IP Right Cessation
-
2004
- 2004-01-07 US US10/753,592 patent/US7390781B2/en not_active Expired - Fee Related
- 2004-05-25 US US10/853,930 patent/US20040214776A1/en not_active Abandoned
- 2004-05-26 US US10/855,820 patent/US7611865B2/en not_active Expired - Fee Related
-
2007
- 2007-09-05 JP JP2007229870A patent/JP4909843B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-21 JP JP2010140665A patent/JP5241037B2/ja not_active Expired - Fee Related
-
2011
- 2011-06-23 US US13/167,419 patent/US20110251267A1/en not_active Abandoned
-
2012
- 2012-02-27 IL IL218336A patent/IL218336A0/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20150916 |