SK287495B6 - Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby - Google Patents

Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby Download PDF

Info

Publication number
SK287495B6
SK287495B6 SK547-2003A SK5472003A SK287495B6 SK 287495 B6 SK287495 B6 SK 287495B6 SK 5472003 A SK5472003 A SK 5472003A SK 287495 B6 SK287495 B6 SK 287495B6
Authority
SK
Slovakia
Prior art keywords
chloro
benzyl
fluoro
phenyl
formula
Prior art date
Application number
SK547-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK5472003A3 (en
Inventor
Christoph-Stephan Hilger
Bernd Johannsen
J�Rg Steinbach
Peter M�Ding
Meredith Halks-Miller
Richard Horuk
Harald Dinter
Raju Mohan
Joseph E. Hesselgesser
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SK5472003A3 publication Critical patent/SK5472003A3/sk
Publication of SK287495B6 publication Critical patent/SK287495B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK547-2003A 2000-11-06 2001-11-01 Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby SK287495B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24629900P 2000-11-06 2000-11-06
PCT/EP2001/012607 WO2002036581A1 (fr) 2000-11-06 2001-11-01 Produits radiopharmaceutiques pour le diagnostic de la maladie d'alzheimer

Publications (2)

Publication Number Publication Date
SK5472003A3 SK5472003A3 (en) 2003-10-07
SK287495B6 true SK287495B6 (sk) 2010-12-07

Family

ID=22930075

Family Applications (1)

Application Number Title Priority Date Filing Date
SK547-2003A SK287495B6 (sk) 2000-11-06 2001-11-01 Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby

Country Status (29)

Country Link
US (2) US6676926B2 (fr)
EP (1) EP1332138B1 (fr)
JP (1) JP4234425B2 (fr)
KR (1) KR20030045167A (fr)
CN (1) CN1473158A (fr)
AR (1) AR035366A1 (fr)
AT (1) ATE314354T1 (fr)
AU (2) AU1403402A (fr)
BG (1) BG107762A (fr)
BR (1) BR0115150A (fr)
CA (1) CA2424598A1 (fr)
DE (1) DE60116365T2 (fr)
EA (1) EA006199B1 (fr)
EE (1) EE200300216A (fr)
HR (1) HRP20030459A2 (fr)
HU (1) HUP0301710A3 (fr)
IL (1) IL155191A0 (fr)
JO (1) JO2207B1 (fr)
MX (1) MXPA03003759A (fr)
NO (1) NO20032007L (fr)
NZ (1) NZ525303A (fr)
PE (1) PE20020531A1 (fr)
PL (1) PL361631A1 (fr)
SK (1) SK287495B6 (fr)
TW (1) TWI238820B (fr)
UY (1) UY27003A1 (fr)
WO (1) WO2002036581A1 (fr)
YU (1) YU33203A (fr)
ZA (1) ZA200304409B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27003A1 (es) * 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
CN1575283A (zh) 2001-10-22 2005-02-02 辉瑞产品公司 具有ccr1受体拮抗剂活性的哌嗪衍生物
WO2003059884A1 (fr) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulateurs de lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
ES2305769T3 (es) * 2003-05-07 2008-11-01 Bayer Schering Pharma Aktiengesellschaft Dispositivo y procedimiento para la fluoracion nucleofila.
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
JP5070038B2 (ja) * 2004-02-24 2012-11-07 ザ ジェネラル ホスピタル コーポレーション 触媒性放射性フッ素化
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
KR100778888B1 (ko) * 2005-11-29 2007-11-28 재단법인서울대학교산학협력재단 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물
CA2663121C (fr) 2006-09-08 2016-01-19 Rhode Island Hospital Traitement, prevention et elimination d'une maladie cerebrale d'origine alcoolique
JP5864077B2 (ja) 2006-09-08 2016-02-17 ロード アイランド ホスピタル アルコール誘発性肝疾患の治療、予防および回復
JP5562036B2 (ja) * 2006-12-21 2014-07-30 ハマースミス・イメイネット・リミテッド 放射性標識方法
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
CA2703563A1 (fr) * 2007-10-31 2009-05-07 Alseres Pharmaceuticals, Inc. Procedes de diagnostic et de surveillance du traitement de la demence a corps de lewy par evaluation des niveaux de transporteur de la dopamine
CA2978149C (fr) 2008-03-21 2019-02-12 The General Hospital Corporation Derives d'inositol destines a la detection et au traitement de la maladie d'alzheimer et de troubles connexes
EP2161256A1 (fr) * 2008-09-08 2010-03-10 Atomic Energy Council - Institute of Nuclear Energy Research Composé contenant un ester de carboxylate et groupes bi-fonctionnels de ligand N2S2 et leur procédé de fabrication
EP2163541A1 (fr) * 2008-09-12 2010-03-17 Bayer Schering Pharma Aktiengesellschaft Dérivés de piprazine pour la liaison et l'imagerie de plaques amyloïdes et leur utilisation
WO2011041470A2 (fr) * 2009-09-30 2011-04-07 Mallinckrodt Inc. Compositions à libération prolongée d'opiacé et de dérivés d'opiacé
TW201201846A (en) * 2010-02-08 2012-01-16 Bayer Schering Pharma Ag Iodo precursor for a PET imaging agent of amyloid plaques
WO2011110511A1 (fr) * 2010-03-11 2011-09-15 Bayer Pharma Aktiengesellschaft Agents pour l'imagerie spect des plaques amyloïdes
WO2012159107A1 (fr) 2011-05-19 2012-11-22 Rhode Island Hospital Inhibition d'une fibrose rénale
ES2973048T3 (es) 2013-12-27 2024-06-18 Univ Nat Corp Tokyo Medical & Dental Método para el diagnóstico de la enfermedad de Alzheimer y la degeneración lobar frontotemporal, agente de diagnóstico, agente terapéutico y método de cribado ("screening") para dichos agentes
DK3340796T3 (da) 2015-08-28 2021-07-26 Chdi Foundation Inc Sonder til afbildning af huntingtin-protein

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016239A1 (fr) 1991-03-13 1992-10-01 The Regents Of The University Of Minnesota Agents radiopharmaceutiques pour la detection de la maladie d'alzheimer
EP0524146A1 (fr) 1991-07-19 1993-01-20 Ciba-Geigy Ag Dérivés de pipérazine substitués par un groupe amino
GB9413772D0 (en) 1994-07-08 1994-08-24 Wyeth John & Brother Ltd 5-HT1A ligands
WO1997040010A1 (fr) * 1996-04-24 1997-10-30 Emory University Piperidines halogenes de natphtyle methoxy servant a representer la topographie d'emplacements du transporteur de serotonine
US6281212B1 (en) 1996-07-12 2001-08-28 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
FR2758328B1 (fr) 1997-01-15 1999-04-02 Pf Medicament Nouvelles amines aromatiques derivees d'amines cycliques utiles comme medicaments
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
AUPP278498A0 (en) * 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AUPP818099A0 (en) 1999-01-14 1999-02-11 Fujisawa Pharmaceutical Co., Ltd. New n-containing heterocyclic compounds
CA2361366A1 (fr) 1999-03-26 2000-10-05 Nicholas Kindon Nouveaux composes
UY27003A1 (es) * 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer

Also Published As

Publication number Publication date
ZA200304409B (en) 2004-09-06
AR035366A1 (es) 2004-05-12
US20020131932A1 (en) 2002-09-19
NO20032007D0 (no) 2003-05-05
AU2002214034B2 (en) 2006-01-05
US6676926B2 (en) 2004-01-13
EP1332138A1 (fr) 2003-08-06
EP1332138B1 (fr) 2005-12-28
DE60116365T2 (de) 2006-08-24
TWI238820B (en) 2005-09-01
BG107762A (en) 2004-03-31
MXPA03003759A (es) 2003-07-28
HUP0301710A3 (en) 2007-03-28
SK5472003A3 (en) 2003-10-07
IL155191A0 (en) 2003-11-23
HUP0301710A2 (hu) 2003-11-28
UY27003A1 (es) 2002-07-31
JO2207B1 (en) 2004-10-07
EA006199B1 (ru) 2005-10-27
YU33203A (sh) 2006-05-25
US6872381B1 (en) 2005-03-29
BR0115150A (pt) 2003-12-30
AU1403402A (en) 2002-05-15
DE60116365D1 (de) 2006-02-02
JP2004513123A (ja) 2004-04-30
EE200300216A (et) 2003-08-15
CN1473158A (zh) 2004-02-04
CA2424598A1 (fr) 2002-05-10
PL361631A1 (en) 2004-10-04
KR20030045167A (ko) 2003-06-09
EA200300507A1 (ru) 2003-12-25
NZ525303A (en) 2004-10-29
NO20032007L (no) 2003-07-02
PE20020531A1 (es) 2002-06-15
HRP20030459A2 (en) 2005-04-30
JP4234425B2 (ja) 2009-03-04
ATE314354T1 (de) 2006-01-15
WO2002036581A1 (fr) 2002-05-10

Similar Documents

Publication Publication Date Title
SK287495B6 (sk) Rádiofarmaceutiká na diagnostikovanie Alzheimerovej choroby
AU2002214034A1 (en) Radiopharmaceuticals for diagnosing alzheimer's disease
TWI245764B (en) Amyloid plaque aggregation inhibitors and diagnostic imaging agents
US8168800B2 (en) Aβ-binding small molecules
CA2924360A1 (fr) Inhibiteurs marques de l'antigene membranaire specifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate
BRPI0113470B1 (pt) Composto de ligação amilóide, composição farmacêutica e métodos de síntese de composto, de detecção in vivo de depósitos amilóides num indivíduo e em tecido humano ou animal, de quantificação de depósito amilóide em tecido de biópsia ou postmortem e de distinção de um cérebro de doença de alzheimer de um cérebro normal
CA2438032A1 (fr) Derives de benzothiazole et compositions et utilisations connexes
JPH11514368A (ja) ドーパミン及びセロトニン輸送体リガンド並びにイメージング剤
CN113710286A (zh) 具有改善的组织特异性的前列腺特异性膜抗原(psma)配体
KR100745445B1 (ko) 종양 영상화 화합물
EP2139481B1 (fr) 1-pipérazin-1'-yl-isoquinoléines substituées en position 2' en tant qu'agents thérapeutiques inhibiteurs du transporteur de la norépinéphrine et agents d'imagerie de tomographie par émission de positrons
EP2280915A1 (fr) Nouveaux dérivés (ii) d'acides l-glutamique et de l-glutamine marqués au ýf-18¨, leur utilisation et leur procédé de production
EP1175388B1 (fr) Agents d'imagerie destines a la tomographie monophotonique d'emission pour transporteurs de serotonine
CA2911307C (fr) Utilisation de derives fluores de 4-aminopyridine en therapeutique et en imagerie medicale
US20140348748A1 (en) Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof
US20240358865A1 (en) Quinolinyl and pridinyl containing compounds targeting on alpha-synuclein for neurological diseases
EP4122500A1 (fr) Produit radiopharmaceutique et composition d'imagerie des thrombus
WO2021026429A1 (fr) Composés de butyrylcholinestérase et leur utilisation dans des maladies du système nerveux

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111101