HRP20030459A2 - Radiopharmaceuticals for diagnosing alzheimer's diseases - Google Patents
Radiopharmaceuticals for diagnosing alzheimer's diseases Download PDFInfo
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- HRP20030459A2 HRP20030459A2 HR20030459A HRP20030459A HRP20030459A2 HR P20030459 A2 HRP20030459 A2 HR P20030459A2 HR 20030459 A HR20030459 A HR 20030459A HR P20030459 A HRP20030459 A HR P20030459A HR P20030459 A2 HRP20030459 A2 HR P20030459A2
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- chloro
- oxoethoxy
- benzyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24629900P | 2000-11-06 | 2000-11-06 | |
| PCT/EP2001/012607 WO2002036581A1 (fr) | 2000-11-06 | 2001-11-01 | Produits radiopharmaceutiques pour le diagnostic de la maladie d'alzheimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20030459A2 true HRP20030459A2 (en) | 2005-04-30 |
Family
ID=22930075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030459A HRP20030459A2 (en) | 2000-11-06 | 2003-06-06 | Radiopharmaceuticals for diagnosing alzheimer's diseases |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6676926B2 (fr) |
| EP (1) | EP1332138B1 (fr) |
| JP (1) | JP4234425B2 (fr) |
| KR (1) | KR20030045167A (fr) |
| CN (1) | CN1473158A (fr) |
| AR (1) | AR035366A1 (fr) |
| AT (1) | ATE314354T1 (fr) |
| AU (2) | AU1403402A (fr) |
| BG (1) | BG107762A (fr) |
| BR (1) | BR0115150A (fr) |
| CA (1) | CA2424598A1 (fr) |
| DE (1) | DE60116365T2 (fr) |
| EA (1) | EA006199B1 (fr) |
| EE (1) | EE200300216A (fr) |
| HR (1) | HRP20030459A2 (fr) |
| HU (1) | HUP0301710A3 (fr) |
| IL (1) | IL155191A0 (fr) |
| JO (1) | JO2207B1 (fr) |
| MX (1) | MXPA03003759A (fr) |
| NO (1) | NO20032007L (fr) |
| NZ (1) | NZ525303A (fr) |
| PE (1) | PE20020531A1 (fr) |
| PL (1) | PL361631A1 (fr) |
| SK (1) | SK287495B6 (fr) |
| TW (1) | TWI238820B (fr) |
| UY (1) | UY27003A1 (fr) |
| WO (1) | WO2002036581A1 (fr) |
| YU (1) | YU33203A (fr) |
| ZA (1) | ZA200304409B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| UY27003A1 (es) * | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
| EA006243B1 (ru) | 2001-10-22 | 2005-10-27 | Пфайзер Продактс Инк. | Производные пиперазина с антагонистической активностью к рецептору ccr1 |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| AU2002351412B2 (en) | 2001-12-21 | 2010-05-20 | Exelixis Patent Company Llc | Modulators of LXR |
| PL1620373T3 (pl) * | 2003-05-07 | 2008-09-30 | Bayer Schering Pharma Ag | Urządzenie i sposób fluorowania nukleofilowego |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| WO2005082425A1 (fr) * | 2004-02-24 | 2005-09-09 | The General Hospital Corporation | Radiofluoration catalytique |
| GB0409236D0 (en) * | 2004-04-26 | 2004-05-26 | Novartis Ag | Organic compounds |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| KR100778888B1 (ko) * | 2005-11-29 | 2007-11-28 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물 |
| KR101922515B1 (ko) | 2006-09-08 | 2019-02-20 | 로드아일랜드하스피틀 | 알코올 유발성 간 질환의 치료, 예방 및 역행 |
| US9308198B2 (en) | 2006-09-08 | 2016-04-12 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
| GB0625523D0 (en) | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
| EP2094625A1 (fr) * | 2006-12-21 | 2009-09-02 | Hammersmith Imanet, Ltd | Procédés de radio-étiquetage |
| JP2011502966A (ja) * | 2007-10-31 | 2011-01-27 | アルセレス ファーマシューティカルズ， インコーポレイテッド | ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法 |
| AU2009225407B2 (en) | 2008-03-21 | 2013-09-05 | The General Hospital Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
| EP2161256A1 (fr) * | 2008-09-08 | 2010-03-10 | Atomic Energy Council - Institute of Nuclear Energy Research | Composé contenant un ester de carboxylate et groupes bi-fonctionnels de ligand N2S2 et leur procédé de fabrication |
| EP2163541A1 (fr) * | 2008-09-12 | 2010-03-17 | Bayer Schering Pharma Aktiengesellschaft | Dérivés de piprazine pour la liaison et l'imagerie de plaques amyloïdes et leur utilisation |
| WO2011041470A2 (fr) * | 2009-09-30 | 2011-04-07 | Mallinckrodt Inc. | Compositions à libération prolongée d'opiacé et de dérivés d'opiacé |
| TW201201846A (en) * | 2010-02-08 | 2012-01-16 | Bayer Schering Pharma Ag | Iodo precursor for a PET imaging agent of amyloid plaques |
| WO2011110511A1 (fr) * | 2010-03-11 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Agents pour l'imagerie spect des plaques amyloïdes |
| WO2012159107A1 (fr) | 2011-05-19 | 2012-11-22 | Rhode Island Hospital | Inhibition d'une fibrose rénale |
| WO2015099094A1 (fr) | 2013-12-27 | 2015-07-02 | 国立大学法人東京医科歯科大学 | Procédé pour le diagnostic de la maladie d'alzheimer et de la dégénérescence lobaire frontotemporale, agent diagnostique, agent thérapeutique, et procédé de dépistage utilisant lesdits agents |
| WO2017040336A1 (fr) * | 2015-08-28 | 2017-03-09 | Chdi Foundation, Inc. | Sondes d'imagerie de la protéine huntingtine |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH06510021A (ja) * | 1991-03-13 | 1994-11-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | アルツハイマー病検出用の放射性薬剤 |
| EP0524146A1 (fr) | 1991-07-19 | 1993-01-20 | Ciba-Geigy Ag | Dérivés de pipérazine substitués par un groupe amino |
| GB9413772D0 (en) | 1994-07-08 | 1994-08-24 | Wyeth John & Brother Ltd | 5-HT1A ligands |
| US5919797A (en) * | 1996-04-24 | 1999-07-06 | Emory University | Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites |
| JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト，インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| FR2758328B1 (fr) | 1997-01-15 | 1999-04-02 | Pf Medicament | Nouvelles amines aromatiques derivees d'amines cycliques utiles comme medicaments |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| AUPP818099A0 (en) | 1999-01-14 | 1999-02-11 | Fujisawa Pharmaceutical Co., Ltd. | New n-containing heterocyclic compounds |
| KR20010108394A (ko) | 1999-03-26 | 2001-12-07 | 다비드 에 질레스 | 신규 화합물 |
| UY27003A1 (es) * | 2000-11-06 | 2002-07-31 | Schering Ag | Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer |
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2001
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- 2001-11-01 PL PL01361631A patent/PL361631A1/xx not_active Application Discontinuation
- 2001-11-01 AT AT01982450T patent/ATE314354T1/de not_active IP Right Cessation
- 2001-11-01 CN CNA01818409XA patent/CN1473158A/zh active Pending
- 2001-11-01 HU HU0301710A patent/HUP0301710A3/hu unknown
- 2001-11-01 YU YU33203A patent/YU33203A/sh unknown
- 2001-11-01 IL IL15519101A patent/IL155191A0/xx unknown
- 2001-11-01 EP EP01982450A patent/EP1332138B1/fr not_active Expired - Lifetime
- 2001-11-01 SK SK547-2003A patent/SK287495B6/sk not_active IP Right Cessation
- 2001-11-01 BR BR0115150-9A patent/BR0115150A/pt not_active IP Right Cessation
- 2001-11-01 DE DE60116365T patent/DE60116365T2/de not_active Expired - Lifetime
- 2001-11-01 AU AU1403402A patent/AU1403402A/xx active Pending
- 2001-11-01 EE EEP200300216A patent/EE200300216A/xx unknown
- 2001-11-01 KR KR10-2003-7006187A patent/KR20030045167A/ko not_active Application Discontinuation
- 2001-11-01 MX MXPA03003759A patent/MXPA03003759A/es unknown
- 2001-11-01 WO PCT/EP2001/012607 patent/WO2002036581A1/fr not_active Application Discontinuation
- 2001-11-01 CA CA002424598A patent/CA2424598A1/fr not_active Abandoned
- 2001-11-01 AU AU2002214034A patent/AU2002214034B2/en not_active Ceased
- 2001-11-01 NZ NZ525303A patent/NZ525303A/en unknown
- 2001-11-01 EA EA200300507A patent/EA006199B1/ru not_active IP Right Cessation
- 2001-11-01 JP JP2002539340A patent/JP4234425B2/ja not_active Expired - Fee Related
- 2001-11-02 AR ARP010105127A patent/AR035366A1/es unknown
- 2001-11-05 JO JO2001178A patent/JO2207B1/en active
- 2001-11-05 PE PE2001001092A patent/PE20020531A1/es not_active Application Discontinuation
- 2001-11-06 TW TW090127552A patent/TWI238820B/zh not_active IP Right Cessation
- 2001-11-06 US US09/985,938 patent/US6676926B2/en not_active Expired - Fee Related
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2003
- 2003-04-25 BG BG107762A patent/BG107762A/xx unknown
- 2003-05-05 NO NO20032007A patent/NO20032007L/no unknown
- 2003-06-05 ZA ZA200304409A patent/ZA200304409B/en unknown
- 2003-06-06 HR HR20030459A patent/HRP20030459A2/hr not_active Application Discontinuation
- 2003-07-25 US US10/626,725 patent/US6872381B1/en not_active Expired - Fee Related
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