SK286047B6 - Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu - Google Patents

Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu Download PDF

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Publication number
SK286047B6
SK286047B6 SK176-2004A SK1762004A SK286047B6 SK 286047 B6 SK286047 B6 SK 286047B6 SK 1762004 A SK1762004 A SK 1762004A SK 286047 B6 SK286047 B6 SK 286047B6
Authority
SK
Slovakia
Prior art keywords
hydrogen
hydrocodone
palladium
process according
ruthenium
Prior art date
Application number
SK176-2004A
Other languages
English (en)
Slovak (sk)
Other versions
SK1762004A3 (sk
Inventor
Du�An Vand�K
Du�An Berke�
Andrej Kolarovi�
Milan Marko
Original Assignee
Zentiva, A. S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva, A. S. filed Critical Zentiva, A. S.
Priority to SK176-2004A priority Critical patent/SK286047B6/sk
Priority to CZ20050210A priority patent/CZ297571B6/cs
Priority to PCT/SK2005/000008 priority patent/WO2005100361A1/fr
Publication of SK1762004A3 publication Critical patent/SK1762004A3/sk
Publication of SK286047B6 publication Critical patent/SK286047B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK176-2004A 2004-04-13 2004-04-13 Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu SK286047B6 (sk)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SK176-2004A SK286047B6 (sk) 2004-04-13 2004-04-13 Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
CZ20050210A CZ297571B6 (cs) 2004-04-13 2005-04-05 Zpusob prípravy derivátu 4,5alfa-epoxy-6-oxomorfinanu
PCT/SK2005/000008 WO2005100361A1 (fr) 2004-04-13 2005-04-07 Methode de preparation de derives de 4,5$g(a)-epoxy-6-oxomorphinane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SK176-2004A SK286047B6 (sk) 2004-04-13 2004-04-13 Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu

Publications (2)

Publication Number Publication Date
SK1762004A3 SK1762004A3 (sk) 2005-11-03
SK286047B6 true SK286047B6 (sk) 2008-01-07

Family

ID=34962972

Family Applications (1)

Application Number Title Priority Date Filing Date
SK176-2004A SK286047B6 (sk) 2004-04-13 2004-04-13 Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu

Country Status (3)

Country Link
CZ (1) CZ297571B6 (fr)
SK (1) SK286047B6 (fr)
WO (1) WO2005100361A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625918B2 (en) 2005-03-11 2009-12-01 Noramco, Inc. Hydrocodone polymorphs
JP2008533049A (ja) * 2005-03-11 2008-08-21 ノランコ・インコーポレーテツド ヒドロコドン多形体
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
EP2152715B1 (fr) 2007-05-04 2010-12-29 Mallinckrodt Inc. Procédé amélioré pour la préparation d'opiacés 6-alpha-hydroxy-n-alkylés
JP2010533719A (ja) 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ607842A (en) 2008-09-30 2013-12-20 Mallinckrodt Llc Processes for the selective amination of ketomorphinans
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US20100261906A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-Keto, 3-Alkoxy Morphinans
US20100261905A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Ruthenium Catalysts for the Production of Hydrocodone, Hydromorphone or a Derivative Thereof
US9040705B2 (en) 2009-04-09 2015-05-26 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds
EP2417139B1 (fr) * 2009-04-09 2016-03-23 Mallinckrodt LLC Préparation de composés cétone saturée morphinanes par isomérisation catalytique
WO2010144640A2 (fr) 2009-06-11 2010-12-16 Mallinckrodt Inc. Amination réductrice de 6-céto normorphinanes par transfert catalytique d'hydrogène
PL2440562T3 (pl) 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
US8383815B2 (en) * 2009-09-21 2013-02-26 Mallinckrodt Llc Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
US8563725B2 (en) 2010-04-29 2013-10-22 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds having low metal content
AU2012267780B2 (en) 2011-06-09 2016-09-08 SpecGx LLC Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
US20130035488A1 (en) * 2011-08-02 2013-02-07 Mallinckrodt Llc Stepwise Process for the Production of Alkaloid Salts
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법
GB201419454D0 (en) * 2014-10-31 2014-12-17 Cambrex Charles City Inc New process
CA2983485A1 (fr) * 2015-04-24 2016-10-27 Grunenthal Gmbh Sels cristallins de bitartrate d'hydrocodone
EP3255051A1 (fr) 2016-06-09 2017-12-13 Siegfried AG Catalyseur métallique supporté pour la production d' hydrocodone et hydromorphon
US10081636B2 (en) 2016-07-08 2018-09-25 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
EP4244226A1 (fr) 2020-11-13 2023-09-20 Ferrer Internacional, S.A. Synthèse d'une base d'hydromorphone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
DE365683C (de) * 1921-03-22 1922-12-22 Knoll & Co Chem Fab Verfahren zur Darstellung von Ketoderivaten der Morphinreihe
DE607931C (de) * 1934-01-26 1935-01-11 Chemische Fabriken Verfahren zur Darstellung von Dihydromorphinonen
US2544291A (en) * 1949-04-05 1951-03-06 New York Quinine And Chemical Alkaloid manufacture
US2649454A (en) * 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics
ATE500257T1 (de) * 1999-11-09 2011-03-15 Abbott Lab Hydromorphinonzusammensetzungen
US7321038B2 (en) * 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process

Also Published As

Publication number Publication date
SK1762004A3 (sk) 2005-11-03
WO2005100361A1 (fr) 2005-10-27
CZ2005210A3 (cs) 2006-09-13
CZ297571B6 (cs) 2007-02-07

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120413