SK285688B6 - Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie - Google Patents
Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie Download PDFInfo
- Publication number
- SK285688B6 SK285688B6 SK1224-97A SK122497A SK285688B6 SK 285688 B6 SK285688 B6 SK 285688B6 SK 122497 A SK122497 A SK 122497A SK 285688 B6 SK285688 B6 SK 285688B6
- Authority
- SK
- Slovakia
- Prior art keywords
- amino
- phenylmethyl
- hydroxy
- methylpropyl
- propyl
- Prior art date
Links
- 0 CC(C)CN(C[C@]([C@](Cc1cccc(**=I)c1)NC([C@](CC#C)NC(CN1CCCC1)=O)=O)O)S(*)=O Chemical compound CC(C)CN(C[C@]([C@](Cc1cccc(**=I)c1)NC([C@](CC#C)NC(CN1CCCC1)=O)=O)O)S(*)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40228795A | 1995-03-10 | 1995-03-10 | |
US08/474,052 US5756533A (en) | 1995-03-10 | 1995-06-07 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
PCT/US1996/002684 WO1996028463A1 (en) | 1995-03-10 | 1996-03-07 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
SK122497A3 SK122497A3 (en) | 1998-03-04 |
SK285688B6 true SK285688B6 (sk) | 2007-06-07 |
Family
ID=23591303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1224-97A SK285688B6 (sk) | 1995-03-10 | 1996-03-07 | Inhibítory retrovírusových proteáz na báze hydroxyetylaminosulfónamidu aminokyselín a ich použitie |
Country Status (23)
Country | Link |
---|---|
US (3) | US5756533A (da) |
EP (2) | EP0813542B1 (da) |
JP (1) | JP4091111B2 (da) |
KR (1) | KR100377855B1 (da) |
CN (1) | CN1204144C (da) |
AT (1) | ATE226213T1 (da) |
AU (1) | AU705268B2 (da) |
BR (1) | BR9607638A (da) |
CA (1) | CA2215061A1 (da) |
CZ (1) | CZ297719B6 (da) |
DE (1) | DE69624346T2 (da) |
DK (1) | DK0813542T3 (da) |
EA (1) | EA000470B1 (da) |
EE (1) | EE04349B1 (da) |
ES (1) | ES2187640T3 (da) |
HU (1) | HUP9801562A3 (da) |
NO (1) | NO974148L (da) |
NZ (1) | NZ303861A (da) |
PL (1) | PL184748B1 (da) |
PT (1) | PT813542E (da) |
SK (1) | SK285688B6 (da) |
UA (1) | UA56130C2 (da) |
WO (1) | WO1996028463A1 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US6140505A (en) * | 1995-03-10 | 2000-10-31 | G. D. Searle & Co. | Synthesis of benzo fused heterocyclic sulfonyl chlorides |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5776971A (en) * | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
PT1088098E (pt) | 1998-06-23 | 2011-05-25 | Univ Illinois | Medicamento para tratar mam?feros infectados com hiv |
AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
EP1095022A1 (en) | 1998-07-08 | 2001-05-02 | G.D. Searle & Co. | Retroviral protease inhibitors |
AR031520A1 (es) * | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
AUPR034000A0 (en) * | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
IL157171A0 (en) * | 2001-02-14 | 2004-02-08 | Tibotec Pharm Ltd | Broadspectrum 2-(substituted-amino) -benzothiazole sulfonamide hiv protease inhibitors |
JP4417010B2 (ja) * | 2001-04-09 | 2010-02-17 | テイボテク・フアーマシユーチカルズ・リミテツド | 広範囲2−(置換−アミノ)−ベンズオキサゾールスルホンアミドhivプロテアーゼ阻害剤 |
CA2444895C (en) * | 2001-05-11 | 2011-02-15 | Tibotec Pharmaceuticals Ltd. | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors |
PL216539B1 (pl) | 2001-12-21 | 2014-04-30 | Tibotec Pharm Ltd | Związki fenylosulfonylowe i zastosowanie związków fenylosulfonylowych |
DE60220319T3 (de) * | 2002-01-31 | 2011-03-17 | Radi Medical Systems Ab | Sich auflösender stent |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
MY142238A (en) * | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
NZ536496A (en) * | 2002-05-17 | 2006-06-30 | Tibotec Pharm Ltd | Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors |
JP4879484B2 (ja) * | 2002-08-02 | 2012-02-22 | テイボテク・フアーマシユーチカルズ・リミテツド | 広スペクトルの2−アミノ−ベンゾチアゾールスルホンアミドhivプロテアーゼ阻害剤 |
KR100994759B1 (ko) | 2002-08-14 | 2010-11-16 | 티보텍 파마슈티컬즈 | 광역스펙트럼의 치환된 옥신돌 설폰아미드 hiv프로테아제 저해제 |
US6943170B2 (en) * | 2002-11-14 | 2005-09-13 | Bristol-Myers Squibb Company | N-cycloalkylglycines as HIV protease inhibitors |
US20060128634A1 (en) * | 2002-11-14 | 2006-06-15 | Carini David J | Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors |
US7772411B2 (en) | 2003-12-23 | 2010-08-10 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
CA2549460C (en) | 2003-12-23 | 2014-08-05 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
JP2007528423A (ja) | 2004-03-11 | 2007-10-11 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
EP2061456A4 (en) * | 2006-08-18 | 2010-10-20 | Sequoia Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR INHIBITING P450 CYTOCHROME |
US8569364B2 (en) | 2007-11-28 | 2013-10-29 | Sequoia Pharmaceuticals, Inc. | 5-substituted benzofurans as inhibitors of cytochrome P450 2D6 |
EP2276726A1 (en) * | 2008-04-18 | 2011-01-26 | University of Connecticut | Compounds for lysosomal modulation and methods of use |
WO2011010524A1 (ja) * | 2009-07-24 | 2011-01-27 | 住友精化株式会社 | アルコキシベンゼンスルホニルクロライドの製造方法 |
KR101994381B1 (ko) | 2011-12-09 | 2019-06-28 | 키에시 파르마슈티시 엣스. 피. 에이. | 키나아제 억제제 |
CN104387299B (zh) * | 2014-10-23 | 2016-08-17 | 凯莱英医药集团(天津)股份有限公司 | 4-氨基-n-[(2r, 3s)-3-氨基-2-羟基-4-苯丁基]-n-异丁基苯磺酰胺的制备方法 |
CN111205206B (zh) * | 2020-02-13 | 2021-10-22 | 中国医学科学院医药生物技术研究所 | 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用 |
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AU7669794A (en) * | 1993-08-24 | 1995-03-21 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
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1995
- 1995-06-07 US US08/474,052 patent/US5756533A/en not_active Expired - Fee Related
-
1996
- 1996-03-07 PT PT96907135T patent/PT813542E/pt unknown
- 1996-03-07 EP EP96907135A patent/EP0813542B1/en not_active Expired - Lifetime
- 1996-03-07 JP JP52764896A patent/JP4091111B2/ja not_active Expired - Fee Related
- 1996-03-07 US US08/894,900 patent/US5968970A/en not_active Expired - Fee Related
- 1996-03-07 BR BR9607638A patent/BR9607638A/pt not_active Application Discontinuation
- 1996-03-07 DK DK96907135T patent/DK0813542T3/da active
- 1996-03-07 AU AU50294/96A patent/AU705268B2/en not_active Ceased
- 1996-03-07 NZ NZ303861A patent/NZ303861A/xx unknown
- 1996-03-07 EE EE9700201A patent/EE04349B1/xx not_active IP Right Cessation
- 1996-03-07 CA CA002215061A patent/CA2215061A1/en not_active Abandoned
- 1996-03-07 DE DE69624346T patent/DE69624346T2/de not_active Expired - Fee Related
- 1996-03-07 CZ CZ0282497A patent/CZ297719B6/cs not_active IP Right Cessation
- 1996-03-07 AT AT96907135T patent/ATE226213T1/de not_active IP Right Cessation
- 1996-03-07 EA EA199700221A patent/EA000470B1/ru not_active IP Right Cessation
- 1996-03-07 ES ES96907135T patent/ES2187640T3/es not_active Expired - Lifetime
- 1996-03-07 KR KR1019970706313A patent/KR100377855B1/ko not_active IP Right Cessation
- 1996-03-07 HU HU9801562A patent/HUP9801562A3/hu unknown
- 1996-03-07 EP EP02011526A patent/EP1258491A1/en not_active Withdrawn
- 1996-03-07 WO PCT/US1996/002684 patent/WO1996028463A1/en active IP Right Grant
- 1996-03-07 PL PL96322784A patent/PL184748B1/pl not_active IP Right Cessation
- 1996-03-07 CN CNB961936207A patent/CN1204144C/zh not_active Expired - Fee Related
- 1996-03-07 SK SK1224-97A patent/SK285688B6/sk unknown
- 1996-07-03 UA UA97104995A patent/UA56130C2/uk unknown
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1997
- 1997-09-09 NO NO974148A patent/NO974148L/no unknown
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1998
- 1998-03-03 US US09/033,897 patent/US5965601A/en not_active Expired - Fee Related
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