SK284791B6 - Použitie 8a-azalidu na liečenie alebo prevenciu bakteriálnych respiračných a enterálnych infekcií poľnohospodárskych zvierat - Google Patents
Použitie 8a-azalidu na liečenie alebo prevenciu bakteriálnych respiračných a enterálnych infekcií poľnohospodárskych zvierat Download PDFInfo
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- SK284791B6 SK284791B6 SK322-2000A SK3222000A SK284791B6 SK 284791 B6 SK284791 B6 SK 284791B6 SK 3222000 A SK3222000 A SK 3222000A SK 284791 B6 SK284791 B6 SK 284791B6
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- Prior art keywords
- alkyl
- amino
- spp
- substituted
- hydrogen
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- 206010057190 Respiratory tract infections Diseases 0.000 title claims abstract description 22
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- 230000000241 respiratory effect Effects 0.000 title claims abstract description 14
- 238000011282 treatment Methods 0.000 title claims abstract description 14
- 230000002265 prevention Effects 0.000 title claims abstract description 10
- 206010022678 Intestinal infections Diseases 0.000 title claims abstract description 6
- 241001465754 Metazoa Species 0.000 title abstract description 17
- 244000144972 livestock Species 0.000 title abstract description 3
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- -1 hydroxy, amino Chemical group 0.000 claims description 87
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- 239000001257 hydrogen Substances 0.000 claims description 36
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
- 125000003118 aryl group Chemical group 0.000 claims description 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 12
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 12
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
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- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims description 4
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 4
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 4
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
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- 230000002335 preservative effect Effects 0.000 description 1
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- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
- 229960005134 pyrantel Drugs 0.000 description 1
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- 210000002345 respiratory system Anatomy 0.000 description 1
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- 229910052711 selenium Inorganic materials 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- JTSDBFGMPLKDCD-XVFHVFLVSA-N tilmicosin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CCN1C[C@H](C)C[C@H](C)C1)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O JTSDBFGMPLKDCD-XVFHVFLVSA-N 0.000 description 1
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- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
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- ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5832997P | 1997-09-10 | 1997-09-10 | |
| GBGB9806029.6A GB9806029D0 (en) | 1998-03-20 | 1998-03-20 | 8a-Azalides as veterinary antimicrobial agents |
| PCT/US1998/018573 WO1999012542A1 (en) | 1997-09-10 | 1998-09-04 | 8a-AZALIDES AS VETERINARY ANTIMICROBIAL AGENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK3222000A3 SK3222000A3 (en) | 2001-01-18 |
| SK284791B6 true SK284791B6 (sk) | 2005-11-03 |
Family
ID=10828979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK322-2000A SK284791B6 (sk) | 1997-09-10 | 1998-09-04 | Použitie 8a-azalidu na liečenie alebo prevenciu bakteriálnych respiračných a enterálnych infekcií poľnohospodárskych zvierat |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP1510214B1 (sl) |
| CN (1) | CN1152681C (sl) |
| AT (2) | ATE535248T1 (sl) |
| AU (1) | AU730172B2 (sl) |
| BR (1) | BR9812066A (sl) |
| CA (1) | CA2301872C (sl) |
| CZ (1) | CZ289868B6 (sl) |
| DE (1) | DE69827814T2 (sl) |
| DK (2) | DK1510214T3 (sl) |
| EA (1) | EA001530B1 (sl) |
| ES (2) | ES2232964T3 (sl) |
| GB (1) | GB9806029D0 (sl) |
| HU (1) | HU228758B1 (sl) |
| IL (1) | IL134762A (sl) |
| ME (1) | ME00858B (sl) |
| NZ (1) | NZ503145A (sl) |
| PL (1) | PL192915B1 (sl) |
| PT (2) | PT1510214E (sl) |
| RS (1) | RS49837B (sl) |
| SI (2) | SI1011664T1 (sl) |
| SK (1) | SK284791B6 (sl) |
| WO (1) | WO1999012542A1 (sl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2788524B1 (fr) * | 1999-01-18 | 2002-04-26 | Merial Sas | Procede utile pour transformer la fonction 4"(s)-oh du motif cladinose d'un aza macrolide en 4"(r)-nh2 |
| US6353096B1 (en) | 1999-04-01 | 2002-03-05 | Merial | Process of use in converting the 4″(S)-OH functional group of the cladinose unit of an azamacrolide to 4″(R)-NH2 |
| GB0025688D0 (en) | 2000-10-19 | 2000-12-06 | Glaxo Group Ltd | Macrolides |
| US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
| US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
| US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
| JP2008540504A (ja) * | 2005-05-10 | 2008-11-20 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 細菌感染症の処置に有用な４’’アミノ結合マクロライド |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281518A (en) * | 1986-05-01 | 1994-01-25 | Washington Research Foundation | Detection of a unique chlamydia strain associated with acute respiratory disease |
| GB8726384D0 (en) * | 1987-11-11 | 1987-12-16 | Coopers Animal Health | Veterinary treatment |
| US4956294A (en) * | 1988-03-07 | 1990-09-11 | Merck & Co., Inc. | Culture of Streptoverticillium synroense for producing an antibacterial |
| CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
| US5202434A (en) * | 1991-04-05 | 1993-04-13 | Merck & Co., Inc. | 8a-aza-8a-homoerythromycin lactams |
| US5189159A (en) * | 1992-04-02 | 1993-02-23 | Merck & Co., Inc. | 8a-AZA-8a-homoerythromycin cyclic iminoethers |
| EP0549040A1 (en) * | 1991-12-20 | 1993-06-30 | Merck & Co. Inc. | Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A |
-
1998
- 1998-03-20 GB GBGB9806029.6A patent/GB9806029D0/en not_active Ceased
- 1998-09-04 HU HU0003845A patent/HU228758B1/hu active Protection Beyond IP Right Term
- 1998-09-04 DK DK04078178.3T patent/DK1510214T3/da active
- 1998-09-04 CA CA002301872A patent/CA2301872C/en not_active Expired - Lifetime
- 1998-09-04 DE DE69827814T patent/DE69827814T2/de not_active Expired - Lifetime
- 1998-09-04 EP EP04078178A patent/EP1510214B1/en not_active Expired - Lifetime
- 1998-09-04 SI SI9830720T patent/SI1011664T1/sl unknown
- 1998-09-04 AT AT04078178T patent/ATE535248T1/de active
- 1998-09-04 SK SK322-2000A patent/SK284791B6/sk not_active IP Right Cessation
- 1998-09-04 EP EP98949319A patent/EP1011664B1/en not_active Expired - Lifetime
- 1998-09-04 SI SI9830934T patent/SI1510214T1/sl unknown
- 1998-09-04 DK DK98949319T patent/DK1011664T3/da active
- 1998-09-04 BR BR9812066-2A patent/BR9812066A/pt not_active Application Discontinuation
- 1998-09-04 AU AU95664/98A patent/AU730172B2/en not_active Expired
- 1998-09-04 CZ CZ2000896A patent/CZ289868B6/cs not_active IP Right Cessation
- 1998-09-04 ME MEP-2000-147A patent/ME00858B/me unknown
- 1998-09-04 ES ES98949319T patent/ES2232964T3/es not_active Expired - Lifetime
- 1998-09-04 PL PL339140A patent/PL192915B1/pl unknown
- 1998-09-04 NZ NZ503145A patent/NZ503145A/xx not_active IP Right Cessation
- 1998-09-04 RS YUP-147/00A patent/RS49837B/sr unknown
- 1998-09-04 WO PCT/US1998/018573 patent/WO1999012542A1/en active IP Right Grant
- 1998-09-04 PT PT04078178T patent/PT1510214E/pt unknown
- 1998-09-04 IL IL13476298A patent/IL134762A/xx not_active IP Right Cessation
- 1998-09-04 EA EA200000305A patent/EA001530B1/ru not_active IP Right Cessation
- 1998-09-04 PT PT98949319T patent/PT1011664E/pt unknown
- 1998-09-04 AT AT98949319T patent/ATE283055T1/de active
- 1998-09-04 ES ES04078178T patent/ES2376432T3/es not_active Expired - Lifetime
- 1998-09-04 CN CNB988109638A patent/CN1152681C/zh not_active Expired - Lifetime
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