SK284041B6 - Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie - Google Patents

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Publication number

SK284041B6

SK284041B6 SK255-99A SK25599A SK284041B6 SK 284041 B6 SK284041 B6 SK 284041B6 SK 25599 A SK25599 A SK 25599A SK 284041 B6 SK284041 B6 SK 284041B6

Authority

SK

Slovakia

Prior art keywords

mmol

mixture

compounds

alkyl

substituted

Prior art date

1996-08-28

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• 239000003475 metalloproteinase inhibitor Substances 0.000 title claims description 13
• 150000001875 compounds Chemical class 0.000 claims abstract description 160
• 102000005741 Metalloproteases Human genes 0.000 claims abstract description 82
• 108010006035 Metalloproteases Proteins 0.000 claims abstract description 82
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 65
• 201000010099 disease Diseases 0.000 claims abstract description 39
• 230000000694 effects Effects 0.000 claims abstract description 37
• 230000003287 optical effect Effects 0.000 claims abstract description 11
• 150000003839 salts Chemical class 0.000 claims abstract description 11
• 150000001408 amides Chemical class 0.000 claims abstract description 10
• 150000002148 esters Chemical class 0.000 claims abstract description 8
• 150000003949 imides Chemical class 0.000 claims abstract description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
• -1 nitro, amino Chemical group 0.000 claims description 69
• 238000011282 treatment Methods 0.000 claims description 49
• 229910052739 hydrogen Inorganic materials 0.000 claims description 40
• 125000000217 alkyl group Chemical group 0.000 claims description 27
• 125000003118 aryl group Chemical group 0.000 claims description 27
• 238000002360 preparation method Methods 0.000 claims description 21
• 125000001072 heteroaryl group Chemical group 0.000 claims description 19
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
• 125000004432 carbon atom Chemical group C* 0.000 claims description 17
• 125000005842 heteroatom Chemical group 0.000 claims description 17
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
• 125000003545 alkoxy group Chemical group 0.000 claims description 14
• 125000000623 heterocyclic group Chemical group 0.000 claims description 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
• 125000004404 heteroalkyl group Chemical group 0.000 claims description 13
• 239000001257 hydrogen Substances 0.000 claims description 12
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
• 125000003342 alkenyl group Chemical group 0.000 claims description 10
• 229910052757 nitrogen Inorganic materials 0.000 claims description 10
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 9
• 125000001424 substituent group Chemical group 0.000 claims description 9
• 125000004104 aryloxy group Chemical group 0.000 claims description 8
• IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims description 8
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
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• 125000004122 cyclic group Chemical group 0.000 claims description 5
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• 229910052717 sulfur Inorganic materials 0.000 claims description 5
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
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• 238000000034 method Methods 0.000 abstract description 57
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• 235000019341 magnesium sulphate Nutrition 0.000 description 34
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