SK283879B6 - Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom - Google Patents

Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom Download PDF

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Publication number
SK283879B6
SK283879B6 SK1029-99A SK102999A SK283879B6 SK 283879 B6 SK283879 B6 SK 283879B6 SK 102999 A SK102999 A SK 102999A SK 283879 B6 SK283879 B6 SK 283879B6
Authority
SK
Slovakia
Prior art keywords
gemcitabine
ester
elaidic acid
amide
derivatives
Prior art date
Application number
SK1029-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK102999A3 (en
Inventor
Finn Myhren
Bernt Borretzen
Are Dalen
Marit Liland Sandvold
Original Assignee
Conpharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9701427A external-priority patent/GB2321454A/en
Application filed by Conpharma As filed Critical Conpharma As
Publication of SK102999A3 publication Critical patent/SK102999A3/sk
Publication of SK283879B6 publication Critical patent/SK283879B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1029-99A 1997-01-24 1998-01-23 Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom SK283879B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides
PCT/NO1998/000020 WO1998032762A1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives

Publications (2)

Publication Number Publication Date
SK102999A3 SK102999A3 (en) 2000-05-16
SK283879B6 true SK283879B6 (sk) 2004-04-06

Family

ID=26310850

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1029-99A SK283879B6 (sk) 1997-01-24 1998-01-23 Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom

Country Status (15)

Country Link
US (1) US6384019B1 (pl)
EP (1) EP0986570B9 (pl)
JP (1) JP4352115B2 (pl)
KR (1) KR100483256B1 (pl)
AT (1) ATE236188T1 (pl)
AU (1) AU720451B2 (pl)
CA (1) CA2278056C (pl)
DE (1) DE69812934T2 (pl)
DK (1) DK0986570T3 (pl)
HU (1) HU224918B1 (pl)
NZ (1) NZ336676A (pl)
PL (1) PL186888B1 (pl)
SK (1) SK283879B6 (pl)
UA (1) UA67736C2 (pl)
WO (1) WO1998032762A1 (pl)

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Also Published As

Publication number Publication date
HUP0000721A2 (hu) 2001-05-28
CA2278056A1 (en) 1998-07-30
SK102999A3 (en) 2000-05-16
HU224918B1 (en) 2006-04-28
JP4352115B2 (ja) 2009-10-28
NZ336676A (en) 2000-01-28
US6384019B1 (en) 2002-05-07
PL186888B1 (pl) 2004-03-31
KR20000070351A (ko) 2000-11-25
US20020042391A1 (en) 2002-04-11
AU5782798A (en) 1998-08-18
HUP0000721A3 (en) 2002-12-28
ATE236188T1 (de) 2003-04-15
KR100483256B1 (ko) 2005-04-15
DE69812934T2 (de) 2004-01-29
WO1998032762A1 (en) 1998-07-30
JP2001509160A (ja) 2001-07-10
PL334856A1 (en) 2000-03-27
AU720451B2 (en) 2000-06-01
DE69812934D1 (de) 2003-05-08
EP0986570A1 (en) 2000-03-22
CA2278056C (en) 2006-12-12
DK0986570T3 (da) 2003-07-28
UA67736C2 (uk) 2004-07-15
EP0986570B9 (en) 2004-01-02
EP0986570B1 (en) 2003-04-02

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Effective date: 20150123