SK283718B6 - Derivát cyklopeptidu, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie - Google Patents

Derivát cyklopeptidu, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie Download PDF

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Publication number
SK283718B6
SK283718B6 SK1364-98A SK136498A SK283718B6 SK 283718 B6 SK283718 B6 SK 283718B6 SK 136498 A SK136498 A SK 136498A SK 283718 B6 SK283718 B6 SK 283718B6
Authority
SK
Slovakia
Prior art keywords
asp
gly
arg
formula
cyclo
Prior art date
Application number
SK1364-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK136498A3 (en
Inventor
Alfred Jonczyk
Simon Goodman
Beate Diefenbach
Horst Kessler
Marcus Koppitz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK136498A3 publication Critical patent/SK136498A3/sk
Publication of SK283718B6 publication Critical patent/SK283718B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SK1364-98A 1996-04-06 1997-04-02 Derivát cyklopeptidu, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie SK283718B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19613933A DE19613933A1 (de) 1996-04-06 1996-04-06 Cyclische Adhäsionsinhibitoren
PCT/EP1997/001657 WO1997038009A1 (de) 1996-04-06 1997-04-02 Cyclische adhäsionsinhibitoren

Publications (2)

Publication Number Publication Date
SK136498A3 SK136498A3 (en) 1999-05-07
SK283718B6 true SK283718B6 (sk) 2003-12-02

Family

ID=7790744

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1364-98A SK283718B6 (sk) 1996-04-06 1997-04-02 Derivát cyklopeptidu, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie

Country Status (24)

Country Link
US (1) US6127335A (zh)
EP (1) EP0904285B1 (zh)
JP (1) JP4115530B2 (zh)
KR (1) KR100438378B1 (zh)
CN (1) CN1119351C (zh)
AR (1) AR006523A1 (zh)
AT (1) ATE224402T1 (zh)
AU (1) AU717496B2 (zh)
BR (1) BR9708530A (zh)
CA (1) CA2250861C (zh)
CZ (1) CZ291510B6 (zh)
DE (2) DE19613933A1 (zh)
DK (1) DK0904285T3 (zh)
ES (1) ES2183159T3 (zh)
HU (1) HUP9903631A3 (zh)
NO (1) NO984667D0 (zh)
PL (1) PL187924B1 (zh)
PT (1) PT904285E (zh)
RU (1) RU2184121C2 (zh)
SK (1) SK283718B6 (zh)
TW (1) TW570929B (zh)
UA (1) UA61071C2 (zh)
WO (1) WO1997038009A1 (zh)
ZA (1) ZA972843B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69930764D1 (de) 1998-12-23 2006-05-18 G D Searle Llc St Louis Verwendung von cyclooxygenase-2 inhibitor celecoxib und capecitabine zur kombinationsbehandlung von neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6521593B1 (en) * 1999-02-01 2003-02-18 Childrens Hospital Los Angeles Methods for inhibiting brain tumor growth
UA71608C2 (en) 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
PL204102B1 (pl) 2000-11-01 2009-12-31 Merck Patent Gmbh Zastosowanie inhibitorów αvß₃ i/lub αvß₅ do otrzymywania leku do profilaktyki i/lub terapii chorób oczu.
US20040029788A1 (en) * 2000-11-01 2004-02-12 Hans-Markus Bender Methods and compositions for the treatment of diseases of the eye
JP4499327B2 (ja) * 2001-12-06 2010-07-07 松崎 浩巳 拡径器具および手術器具セット
WO2003075741A2 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. METHODS OF PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN αvβ3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE
US20040001835A1 (en) * 2002-03-04 2004-01-01 Medimmune, Inc. Prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
ITRM20020402A1 (it) * 2002-07-29 2004-01-29 Sigma Tau Ind Farmaceuti Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
CA2496127C (en) * 2002-08-16 2012-05-29 Janssen Pharmaceutica N.V. Piperidinyl compounds that selectively bind integrins
JP2006516635A (ja) * 2003-01-30 2006-07-06 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストの使用
CN101990425B (zh) * 2008-04-08 2016-01-20 默克专利股份有限公司 包含环肽的组合物和使用方法
US10745444B2 (en) 2017-04-17 2020-08-18 National Tsing Hua University Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
ES2904658T3 (es) * 2017-04-17 2022-04-05 Univ Nat Tsing Hua Método para preparar un ciclopéptido
US10494403B2 (en) 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077279A (zh) * 1992-04-09 1993-10-13 北京矿冶研究总院 雷管桥丝发火电阻安全检测仪
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren

Also Published As

Publication number Publication date
JP4115530B2 (ja) 2008-07-09
CN1119351C (zh) 2003-08-27
CZ291510B6 (cs) 2003-03-12
NO984667L (no) 1998-10-06
RU2184121C2 (ru) 2002-06-27
DK0904285T3 (da) 2003-01-27
HUP9903631A3 (en) 2000-04-28
PL187924B1 (pl) 2004-11-30
AU2568897A (en) 1997-10-29
CA2250861A1 (en) 1997-10-16
DE19613933A1 (de) 1997-10-09
UA61071C2 (en) 2003-11-17
DE59708269D1 (de) 2002-10-24
EP0904285A1 (de) 1999-03-31
WO1997038009A1 (de) 1997-10-16
BR9708530A (pt) 1999-08-03
KR100438378B1 (ko) 2004-08-25
CZ320398A3 (cs) 1999-01-13
SK136498A3 (en) 1999-05-07
HUP9903631A2 (hu) 2000-03-28
ZA972843B (en) 1998-02-19
JP2000510102A (ja) 2000-08-08
AU717496B2 (en) 2000-03-30
ES2183159T3 (es) 2003-03-16
CA2250861C (en) 2008-07-15
CN1218478A (zh) 1999-06-02
NO984667D0 (no) 1998-10-06
ATE224402T1 (de) 2002-10-15
PT904285E (pt) 2003-02-28
AR006523A1 (es) 1999-09-08
EP0904285B1 (de) 2002-09-18
US6127335A (en) 2000-10-03
TW570929B (en) 2004-01-11
PL329154A1 (en) 1999-03-15
KR20000005210A (ko) 2000-01-25

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