SK283332B6 - Difenylalkyltetrahydropyridíny, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú - Google Patents
Difenylalkyltetrahydropyridíny, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú Download PDFInfo
- Publication number
- SK283332B6 SK283332B6 SK787-99A SK78799A SK283332B6 SK 283332 B6 SK283332 B6 SK 283332B6 SK 78799 A SK78799 A SK 78799A SK 283332 B6 SK283332 B6 SK 283332B6
- Authority
- SK
- Slovakia
- Prior art keywords
- tetrahydropyridine
- formula
- group
- ethyl
- trifluoromethylphenyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 22
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- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- XVFJONKUSLSKSW-JTQLQIEISA-N talsaclidine Chemical compound C1CC2[C@@H](OCC#C)CN1CC2 XVFJONKUSLSKSW-JTQLQIEISA-N 0.000 description 1
- 229950001645 talsaclidine Drugs 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229950001843 velnacrine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- WJJYZXPHLSLMGE-UHFFFAOYSA-N xaliproden Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=CC=CC4=CC=3)CC=2)=C1 WJJYZXPHLSLMGE-UHFFFAOYSA-N 0.000 description 1
- JOLJIIDDOBNFHW-UHFFFAOYSA-N xanomeline Chemical compound CCCCCCOC1=NSN=C1C1=CCCN(C)C1 JOLJIIDDOBNFHW-UHFFFAOYSA-N 0.000 description 1
- 229950006755 xanomeline Drugs 0.000 description 1
- 229950004402 zifrosilone Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615336A FR2757161B1 (fr) | 1996-12-13 | 1996-12-13 | Diphenylalkyl-tetrahydropyridines |
| PCT/FR1997/002289 WO1998025904A1 (fr) | 1996-12-13 | 1997-12-12 | Diphenylalkyl-tetrahydropyridines, procede pour leur preparation et composition pharmaceutique les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK78799A3 SK78799A3 (en) | 1999-12-10 |
| SK283332B6 true SK283332B6 (sk) | 2003-06-03 |
Family
ID=9498642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK787-99A SK283332B6 (sk) | 1996-12-13 | 1997-12-12 | Difenylalkyltetrahydropyridíny, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6124318A (cs) |
| EP (1) | EP0950049B1 (cs) |
| JP (1) | JP2001505903A (cs) |
| KR (1) | KR100549656B1 (cs) |
| CN (1) | CN1144784C (cs) |
| AT (1) | ATE207056T1 (cs) |
| AU (1) | AU730142B2 (cs) |
| BR (1) | BR9713926A (cs) |
| CA (1) | CA2274946C (cs) |
| CY (1) | CY2282B1 (cs) |
| CZ (1) | CZ290242B6 (cs) |
| DE (1) | DE69707504T2 (cs) |
| DK (1) | DK0950049T3 (cs) |
| EE (1) | EE03764B1 (cs) |
| ES (1) | ES2167805T3 (cs) |
| FR (1) | FR2757161B1 (cs) |
| HU (1) | HUP0001437A3 (cs) |
| IL (2) | IL130001A0 (cs) |
| IS (1) | IS2001B (cs) |
| NO (1) | NO313282B1 (cs) |
| NZ (1) | NZ336032A (cs) |
| PL (1) | PL192926B1 (cs) |
| PT (1) | PT950049E (cs) |
| RS (1) | RS49672B (cs) |
| RU (1) | RU2198874C2 (cs) |
| SI (1) | SI0950049T1 (cs) |
| SK (1) | SK283332B6 (cs) |
| TR (1) | TR199901290T2 (cs) |
| UA (1) | UA52708C2 (cs) |
| WO (1) | WO1998025904A1 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| US20030060487A1 (en) * | 2000-04-12 | 2003-03-27 | Bamdad R. Shoshana | Treatment of neurodegenerative disease |
| US6699866B2 (en) | 2001-04-17 | 2004-03-02 | Sepracor Inc. | Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof |
| US20050191349A1 (en) * | 2003-12-31 | 2005-09-01 | Garth Boehm | Galantamine formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| BE775611A (fr) * | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| US5266573A (en) * | 1989-08-07 | 1993-11-30 | Elf Sanofi | Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders |
| FR2650505B1 (fr) * | 1989-08-07 | 1994-06-03 | Midy Spa | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale |
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
| HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
| DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
-
1996
- 1996-12-13 FR FR9615336A patent/FR2757161B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-11 US US09/331,005 patent/US6124318A/en not_active Expired - Fee Related
- 1997-12-12 UA UA99063287A patent/UA52708C2/uk unknown
- 1997-12-12 ES ES97951326T patent/ES2167805T3/es not_active Expired - Lifetime
- 1997-12-12 HU HU0001437A patent/HUP0001437A3/hu unknown
- 1997-12-12 AT AT97951326T patent/ATE207056T1/de not_active IP Right Cessation
- 1997-12-12 AU AU54895/98A patent/AU730142B2/en not_active Ceased
- 1997-12-12 PL PL334073A patent/PL192926B1/pl not_active IP Right Cessation
- 1997-12-12 SI SI9730241T patent/SI0950049T1/xx unknown
- 1997-12-12 JP JP52632398A patent/JP2001505903A/ja not_active Ceased
- 1997-12-12 DE DE69707504T patent/DE69707504T2/de not_active Expired - Fee Related
- 1997-12-12 TR TR1999/01290T patent/TR199901290T2/xx unknown
- 1997-12-12 SK SK787-99A patent/SK283332B6/sk unknown
- 1997-12-12 DK DK97951326T patent/DK0950049T3/da active
- 1997-12-12 IL IL13000197A patent/IL130001A0/xx active IP Right Grant
- 1997-12-12 EE EEP199900238A patent/EE03764B1/xx not_active IP Right Cessation
- 1997-12-12 CZ CZ19992110A patent/CZ290242B6/cs not_active IP Right Cessation
- 1997-12-12 EP EP97951326A patent/EP0950049B1/fr not_active Expired - Lifetime
- 1997-12-12 KR KR1019997005202A patent/KR100549656B1/ko not_active Expired - Fee Related
- 1997-12-12 PT PT97951326T patent/PT950049E/pt unknown
- 1997-12-12 BR BR9713926A patent/BR9713926A/pt not_active Application Discontinuation
- 1997-12-12 NZ NZ336032A patent/NZ336032A/xx unknown
- 1997-12-12 RS YUP-263/99A patent/RS49672B/sr unknown
- 1997-12-12 WO PCT/FR1997/002289 patent/WO1998025904A1/fr not_active Ceased
- 1997-12-12 CN CNB971805830A patent/CN1144784C/zh not_active Expired - Fee Related
- 1997-12-12 CA CA002274946A patent/CA2274946C/en not_active Expired - Fee Related
- 1997-12-12 RU RU99115082/04A patent/RU2198874C2/ru not_active IP Right Cessation
-
1999
- 1999-05-18 IL IL130001A patent/IL130001A/en not_active IP Right Cessation
- 1999-06-10 IS IS5074A patent/IS2001B/is unknown
- 1999-06-11 NO NO19992870A patent/NO313282B1/no unknown
-
2002
- 2002-05-15 CY CY0200036A patent/CY2282B1/xx unknown
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