SK282616B6 - Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty - Google Patents

Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty Download PDF

Info

Publication number
SK282616B6
SK282616B6 SK55-96A SK5596A SK282616B6 SK 282616 B6 SK282616 B6 SK 282616B6 SK 5596 A SK5596 A SK 5596A SK 282616 B6 SK282616 B6 SK 282616B6
Authority
SK
Slovakia
Prior art keywords
carbon atoms
alkyl
group
substituted
unsubstituted
Prior art date
Application number
SK55-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK5596A3 (en
Inventor
David Askin
Ralph P. Volante
Kan K. Eng
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,664 external-priority patent/US5463067A/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK5596A3 publication Critical patent/SK5596A3/sk
Publication of SK282616B6 publication Critical patent/SK282616B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK55-96A 1993-07-16 1994-07-11 Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty SK282616B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9322593A 1993-07-16 1993-07-16
US08/187,664 US5463067A (en) 1993-07-16 1994-01-26 Process for making HIV protease inhibitors
PCT/US1994/007706 WO1995002584A2 (en) 1993-07-16 1994-07-11 Process for making hiv protease inhibitors

Publications (2)

Publication Number Publication Date
SK5596A3 SK5596A3 (en) 1997-01-08
SK282616B6 true SK282616B6 (sk) 2002-10-08

Family

ID=26787287

Family Applications (1)

Application Number Title Priority Date Filing Date
SK55-96A SK282616B6 (sk) 1993-07-16 1994-07-11 Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty

Country Status (22)

Country Link
US (2) US5491238A (fi)
EP (1) EP0708762B1 (fi)
JP (1) JP3547136B2 (fi)
CN (2) CN1066723C (fi)
AT (1) ATE200079T1 (fi)
AU (1) AU676079B2 (fi)
CZ (1) CZ293953B6 (fi)
DE (1) DE69426979T2 (fi)
DK (1) DK0708762T3 (fi)
ES (1) ES2155091T3 (fi)
FI (1) FI119473B (fi)
GR (1) GR3035645T3 (fi)
HU (1) HUT74583A (fi)
IL (1) IL110342A (fi)
LV (1) LV12825B (fi)
NO (1) NO306297B1 (fi)
NZ (1) NZ269904A (fi)
PL (1) PL179039B1 (fi)
PT (1) PT708762E (fi)
RU (1) RU2125561C1 (fi)
SK (1) SK282616B6 (fi)
WO (1) WO1995002584A2 (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ATE163642T1 (de) * 1994-11-04 1998-03-15 Yamakawa Chemical Ind Verfahren zur herstellung von optisch aktiven piperazinderivaten und zwischenprodukten für ihre herstellung
DE4446025A1 (de) * 1994-12-22 1996-06-27 Basf Ag 2-Caroxamido-1,4,5,6-tetrahydropyrazine
EP1125930A1 (de) * 1995-05-23 2001-08-22 Lonza Ag Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
EP0744401B1 (de) * 1995-05-23 2001-11-21 Lonza Ag Verfahren zur Herstellung von optisch aktiven 2-Piperazincarbonsäurederivaten
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en) 1997-03-07 2003-11-11 Merck & Co., Inc. Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en) 2000-06-20 2002-11-19 Merck & Co., Inc. Process for preparing acetonides
US7218837B2 (en) 2000-09-25 2007-05-15 Victor Company Of Japan, Ltd. Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2052907A1 (en) * 1990-10-11 1992-04-12 Joseph P. Vacca Hiv protease inhibitors having symmetrical structure
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides

Also Published As

Publication number Publication date
IL110342A0 (en) 1994-10-21
WO1995002584A2 (en) 1995-01-26
EP0708762B1 (en) 2001-03-28
ATE200079T1 (de) 2001-04-15
AU7358894A (en) 1995-02-13
US5491238A (en) 1996-02-13
HU9600077D0 (en) 1996-03-28
CZ13196A3 (en) 1996-04-17
NO960168D0 (no) 1996-01-15
IL110342A (en) 1998-12-27
DE69426979T2 (de) 2001-09-20
NO960168L (no) 1996-03-15
FI119473B (fi) 2008-11-28
GR3035645T3 (en) 2001-06-29
PL312613A1 (en) 1996-04-29
RU2125561C1 (ru) 1999-01-27
CN1252402A (zh) 2000-05-10
LV12825A (en) 2002-05-20
NO306297B1 (no) 1999-10-18
CZ293953B6 (cs) 2004-08-18
PT708762E (pt) 2001-07-31
AU676079B2 (en) 1997-02-27
JP3547136B2 (ja) 2004-07-28
SK5596A3 (en) 1997-01-08
PL179039B1 (pl) 2000-07-31
CN1130380A (zh) 1996-09-04
DE69426979D1 (de) 2001-05-03
FI960184A0 (fi) 1996-01-15
DK0708762T3 (da) 2001-04-30
FI960184A (fi) 1996-03-14
HUT74583A (en) 1997-01-28
NZ269904A (en) 1997-11-24
ES2155091T3 (es) 2001-05-01
JPH08509985A (ja) 1996-10-22
CN1066723C (zh) 2001-06-06
LV12825B (en) 2002-09-20
WO1995002584A3 (en) 1995-03-09
US5496948A (en) 1996-03-05
CN1192014C (zh) 2005-03-09
EP0708762A1 (en) 1996-05-01

Similar Documents

Publication Publication Date Title
CZ287610B6 (cs) Pentanamidové deriváty a farmaceutický prostředek s jejich obsahem
SK282616B6 (sk) Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty
RU2134263C1 (ru) Способ получения промежуточных соединений, используемых для синтеза ингибиторов вич-протеазы
SK100696A3 (en) Racemization method of optically clean substrate of 2-tert. butylcarboxamide piperazine or the 2-tert. butylcarboxamide piperazine-reach substrate or its salts
US5463067A (en) Process for making HIV protease inhibitors
CZ266396A3 (cs) Regioselektivní způsob výroby cis-l-amino-2-indanolu
CZ266196A3 (cs) Regioselektivní způsob výroby cis-1-amino-2-indanolu
CA2167183C (en) Process for making hiv protease inhibitors

Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20100429

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20110711