SK282549B6 - Spôsob stabilizácie naloxonhydrochloridu - Google Patents

Spôsob stabilizácie naloxonhydrochloridu Download PDF

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Publication number
SK282549B6
SK282549B6 SK1092-99A SK109299A SK282549B6 SK 282549 B6 SK282549 B6 SK 282549B6 SK 109299 A SK109299 A SK 109299A SK 282549 B6 SK282549 B6 SK 282549B6
Authority
SK
Slovakia
Prior art keywords
acid
derivatives
stabilizer
naloxone
salts
Prior art date
Application number
SK1092-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK109299A3 (en
Inventor
Bernd Raffelsberger
Original Assignee
G�decke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G�decke Aktiengesellschaft filed Critical G�decke Aktiengesellschaft
Publication of SK109299A3 publication Critical patent/SK109299A3/sk
Publication of SK282549B6 publication Critical patent/SK282549B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cereal-Derived Products (AREA)
  • Organic Insulating Materials (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
SK1092-99A 1997-02-14 1998-02-03 Spôsob stabilizácie naloxonhydrochloridu SK282549B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19705537 1997-02-14
PCT/EP1998/000556 WO1998035679A1 (fr) 1997-02-14 1998-02-03 Stabilisation d'hydrochlorure de naloxone

Publications (2)

Publication Number Publication Date
SK109299A3 SK109299A3 (en) 2000-08-14
SK282549B6 true SK282549B6 (sk) 2002-10-08

Family

ID=7820153

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1092-99A SK282549B6 (sk) 1997-02-14 1998-02-03 Spôsob stabilizácie naloxonhydrochloridu

Country Status (10)

Country Link
EP (1) EP0880352B1 (fr)
AT (1) ATE186643T1 (fr)
CZ (1) CZ297951B6 (fr)
DE (1) DE59800046D1 (fr)
ES (1) ES2141631T3 (fr)
GR (1) GR3032458T3 (fr)
HU (1) HU224964B1 (fr)
PL (1) PL190293B1 (fr)
SK (1) SK282549B6 (fr)
WO (1) WO1998035679A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE210983T1 (de) * 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PL193273B1 (pl) 1997-12-22 2007-01-31 Euro Celtique Sa Postać dawkowania doustnego
PL341309A1 (en) 1997-12-22 2001-04-09 Euro Celtique Method of preventing overdosage of opioidic preparations
CN1423559A (zh) 2000-02-08 2003-06-11 欧罗赛铁克股份有限公司 包含阿片样激动剂和拮抗剂的控释组合物
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
DE60238756D1 (de) 2001-05-11 2011-02-10 Endo Pharmaceuticals Inc Opioid enthaltende arzneiform gegen missbrauch
WO2003013433A2 (fr) 2001-08-06 2003-02-20 Euro-Celtique S.A. Formulations d'antagoniste sequestre
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
CN1652752A (zh) 2002-03-14 2005-08-10 欧罗赛铁克股份有限公司 盐酸纳曲酮组合物
CA2478523A1 (fr) 2002-04-05 2003-10-16 Euro-Celtique S.A. Matrice pour liberation prolongee, constante et independante de composes actifs
EP2422772A3 (fr) 2002-09-20 2012-04-18 Alpharma, Inc. Séquestration de sous-unité et compositions et procédés associés
PL2368553T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (fr) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioides pour le traitement de la bronchopneumopathie chronique obstructive
EP1702558A1 (fr) 2005-02-28 2006-09-20 Euro-Celtique S.A. Procédé et dispositif pour évaluer la fonction de l'activité intestinale
HUE032156T2 (en) 2006-06-19 2017-09-28 Alpharma Pharmaceuticals Llc Pharmaceutical preparations
KR101491656B1 (ko) 2007-04-26 2015-02-09 도레이 카부시키가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 고형 제제
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2676881C (fr) 2008-09-30 2017-04-25 Wyeth Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
ES2660001T3 (es) 2008-10-24 2018-03-20 Toray Industries, Inc. Comprimido estable que contiene un derivado de 4,5-epoximorfinano
ES2706407T3 (es) 2009-03-10 2019-03-28 Euro Celtique Sa Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
NZ703564A (en) 2010-03-11 2016-08-26 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
KR20130030261A (ko) 2010-05-10 2013-03-26 유로-셀티큐 에스.에이. 활성제-무함유 과립 및 그를 포함하는 정제의 제조
CA2798885C (fr) 2010-05-10 2014-11-18 Euro-Celtique S.A. Combinaison de granules charges de principe actif et de principes actifs supplementaires
CA2795324C (fr) * 2012-11-09 2015-07-14 Purdue Pharma Compositions pharmaceutiques comprenant de l'hydromorphone et de la naloxone
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
CN112716955A (zh) 2013-11-13 2021-04-30 欧洲凯尔特公司 用于治疗疼痛和阿片样物质肠功能障碍综合征的氢吗啡酮和纳洛酮
WO2015095644A1 (fr) 2013-12-20 2015-06-25 AntiOP, Inc. Compositions de naloxone intranasales et leurs procédés de préparation et d'utilisation
US11135155B2 (en) 2014-07-08 2021-10-05 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
JP2017519803A (ja) * 2014-07-08 2017-07-20 インシス・ファーマ・インコーポレーテッド 舌下ナロキソンスプレー

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276692B6 (cs) * 1990-08-29 1992-07-15 Z Presneho Strojirenstvi Zařízení k řazení hřebíků v násypce plníce
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
AU2059297A (en) * 1996-03-12 1997-10-01 Alza Corporation Composition and dosage form comprising opioid antagonist

Also Published As

Publication number Publication date
DE59800046D1 (de) 1999-12-23
CZ289699A3 (cs) 2000-02-16
SK109299A3 (en) 2000-08-14
HUP0001094A3 (en) 2001-02-28
PL190293B1 (pl) 2005-11-30
WO1998035679A1 (fr) 1998-08-20
CZ297951B6 (cs) 2007-05-02
GR3032458T3 (en) 2000-05-31
HU224964B1 (en) 2006-04-28
EP0880352A2 (fr) 1998-12-02
ES2141631T3 (es) 2000-03-16
HUP0001094A2 (hu) 2000-09-28
ATE186643T1 (de) 1999-12-15
EP0880352B1 (fr) 1999-11-17
PL335249A1 (en) 2000-04-10

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MK4A Patent expired

Expiry date: 20180203