HUP0001094A2 - Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények - Google Patents

Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények

Info

Publication number
HUP0001094A2
HUP0001094A2 HU0001094A HUP0001094A HUP0001094A2 HU P0001094 A2 HUP0001094 A2 HU P0001094A2 HU 0001094 A HU0001094 A HU 0001094A HU P0001094 A HUP0001094 A HU P0001094A HU P0001094 A2 HUP0001094 A2 HU P0001094A2
Authority
HU
Hungary
Prior art keywords
naloxone
stabilization
pharmaceutical compositions
compositions containing
stable pharmaceutical
Prior art date
Application number
HU0001094A
Other languages
English (en)
Inventor
Bernd Raffelsberger
Original Assignee
Gödecke Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gödecke Aktiengesellschaft filed Critical Gödecke Aktiengesellschaft
Publication of HUP0001094A2 publication Critical patent/HUP0001094A2/hu
Publication of HUP0001094A3 publication Critical patent/HUP0001094A3/hu
Publication of HU224964B1 publication Critical patent/HU224964B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

A találmány tárgya eljárás nalőxőn és sói stabilizálására őldatőkban,valamint szilárd és félig szilárd anyagkeverékekben különösenfőlyékőny és szilárd gyógyszerfőrmákban. A találmány értelmébenszerves vagy szervetlen stabilizátőrt adnak a nalőxőnhőz őlyanmennyiségben, amely meggátőlja a nalőxőnnak 2,2'-dinalőxőnná történődimerizációját. A találmány tővábbi tárgyát képezik a stabilizátőrőkattartalmazó gyógyszerfőrmák. ŕ
HU0001094A 1997-02-14 1998-02-03 Process for stabilization of naloxone and stable pharmaceutical compositions containing naloxone HU224964B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19705537 1997-02-14
PCT/EP1998/000556 WO1998035679A1 (de) 1997-02-14 1998-02-03 Stabilisierung von naloxonhydrochlorid

Publications (3)

Publication Number Publication Date
HUP0001094A2 true HUP0001094A2 (hu) 2000-09-28
HUP0001094A3 HUP0001094A3 (en) 2001-02-28
HU224964B1 HU224964B1 (en) 2006-04-28

Family

ID=7820153

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001094A HU224964B1 (en) 1997-02-14 1998-02-03 Process for stabilization of naloxone and stable pharmaceutical compositions containing naloxone

Country Status (10)

Country Link
EP (1) EP0880352B1 (hu)
AT (1) ATE186643T1 (hu)
CZ (1) CZ297951B6 (hu)
DE (1) DE59800046D1 (hu)
ES (1) ES2141631T3 (hu)
GR (1) GR3032458T3 (hu)
HU (1) HU224964B1 (hu)
PL (1) PL190293B1 (hu)
SK (1) SK282549B6 (hu)
WO (1) WO1998035679A1 (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE210983T1 (de) * 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
DK1041987T3 (da) 1997-12-22 2006-08-21 Euro Celtique Sa Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
HUP0100310A3 (en) 1997-12-22 2002-11-28 Euro Celtique Sa A method of preventing abuse of opioid dosage forms
RS50407B (sr) 2000-02-08 2009-12-31 Euro-Celtique S.A., Oralne formulacije opijatnog agonista otporne na mehaničke,termičke i/ili hemijske promene fizičkih osobina doznog oblika
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
MXPA04001210A (es) 2001-08-06 2004-07-08 Euro Celtique Sa Formulaciones de agonista opioide con antagonista liberable y aislado.
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
US20140271788A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
ATE510534T1 (de) 2002-03-14 2011-06-15 Euro Celtique Sa Naltrexonhydrochlorid-zusammensetzungen
CN102813654A (zh) 2002-04-05 2012-12-12 欧洲凯尔蒂克公司 含有羟氢可待酮和烯丙羟吗啡酮的药物制剂
PT1551372T (pt) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Subunidade de sequestração e composições e métodos relacionados
MXPA05010817A (es) † 2003-04-08 2006-03-30 Progenics Pharm Inc Formulaciones farmaceuticas que contienen metilnaltrexona.
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP2526932B1 (en) 2006-06-19 2017-06-07 Alpharma Pharmaceuticals LLC Pharmaceutical composition
PL2151241T3 (pl) 2007-04-26 2012-08-31 Toray Industries Trwały stały preparat zawierający pochodną 4,5-epoksymorfinanową
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
PT2356989T (pt) 2008-10-24 2018-03-09 Toray Industries Comprimido estável contendo derivado de 4,5-epoximorfinano
WO2010103039A1 (en) 2009-03-10 2010-09-16 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
US8524276B2 (en) 2010-03-11 2013-09-03 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone
AU2011252040C1 (en) 2010-05-10 2015-04-02 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
CN103002881B (zh) 2010-05-10 2015-09-02 欧洲凯尔特公司 载有活性剂的颗粒与额外活性剂的组合
CA2795324C (en) * 2012-11-09 2015-07-14 Purdue Pharma Pharmaceutical compositions comprising hydromorphone and naloxone
CA2918004C (en) 2013-07-23 2018-11-20 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
UA116405C2 (uk) 2013-11-13 2018-03-12 Євро-Селтік С.А. Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику
CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
CA2954370A1 (en) * 2014-07-08 2016-01-14 Insys Pharma, Inc. Sublingual naloxone spray

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276692B6 (cs) * 1990-08-29 1992-07-15 Z Presneho Strojirenstvi Zařízení k řazení hřebíků v násypce plníce
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
PT914097E (pt) * 1996-03-12 2002-06-28 Alza Corp Composicao e forma de dosagem compreendendo antagonista de opioide

Also Published As

Publication number Publication date
PL190293B1 (pl) 2005-11-30
CZ297951B6 (cs) 2007-05-02
EP0880352A2 (de) 1998-12-02
ES2141631T3 (es) 2000-03-16
ATE186643T1 (de) 1999-12-15
DE59800046D1 (de) 1999-12-23
CZ289699A3 (cs) 2000-02-16
GR3032458T3 (en) 2000-05-31
SK109299A3 (en) 2000-08-14
HU224964B1 (en) 2006-04-28
PL335249A1 (en) 2000-04-10
WO1998035679A1 (de) 1998-08-20
EP0880352B1 (de) 1999-11-17
SK282549B6 (sk) 2002-10-08
HUP0001094A3 (en) 2001-02-28

Similar Documents

Publication Publication Date Title
HUP0001094A2 (hu) Eljárás naloxon és sói stabilizálására, és naloxont tartalmazó, stabilizált gyógyszerkészítmények
DK0722313T3 (da) Viskoelastiske sammensætninger af fluorerede organiske forbindelser
HUP0100625A2 (hu) Dibenzilidén-szorbitot és funkcionalizált szilikonokat tartalmazó kozmetikai készítmények
DE69812343D1 (de) Feste pharmazeutische formulierungen enthaltend eine physische mischung aus sulphoalkylethercyclodextrin und einem therapeutischen wirkstoff
BR9809865A (pt) Fixador de perfume, perfume e produto base misturados com o mesmo, e, produto perfumado.
RU94043772A (ru) Пропинил-диароматические соединения, фармацевтические и косметические составы на их основе
HUP9900717A2 (hu) Szilárd dezodoráló készítmény
KR960034164A (ko) 스틸벤 유도체 및 이를 함유하는 약제학적 조성물
FI20055562A (fi) Alfa-interferonin stabiilit vesiliuosformulaatit
DE69313455D1 (de) Feuchthaltende lippenstiftzusammensetzungen
TR199800019T1 (xx) Trombosit topaklanmas�n� �nleyici yeni maddeler.
FI20000172A (fi) Itse-emulgoituvan valmisteen muodossa oleva farmaseuttinen koostumus happamia lipoifiilisia yhdisteitä varten
ATE321543T1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
SE8404065D0 (sv) Novel biologically active compounds
HUT55034A (en) Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
TR200000153T2 (tr) İl-5 inhibite eden 6-azaurasil türevleri.
SE8600658D0 (sv) Novel composition of matter
ITMI931685A0 (it) Nuovi derivati di polialchil-4-piperidinoli atti all'impiego come stabilizzanti per materiali organici
HUT53481A (en) Process for stabilization of derivatives os izotiasolone
FI923751A0 (fi) Hexahydrobenso/f/kinolinoner.
HUP9702348A2 (hu) Új, véralvadásgátló hatású glikozidok és az ezeket tartalmazó gyógyszerkészítmények
RU94036762A (ru) Гетероарилпиперидины, способ их получения, промежуточные соединения синтеза и фармацевтическая композиция
DE59004292D1 (de) Renin-hemmende Aminooligohydroxy-Derivate.
DE69222143D1 (de) Indanderivate
KR950016756A (ko) 피로회복제 조성물