SK282278B6 - Spôsob oxidácie delta-5-steroidného alkénu - Google Patents

Spôsob oxidácie delta-5-steroidného alkénu Download PDF

Info

Publication number
SK282278B6
SK282278B6 SK1478-96A SK147896A SK282278B6 SK 282278 B6 SK282278 B6 SK 282278B6 SK 147896 A SK147896 A SK 147896A SK 282278 B6 SK282278 B6 SK 282278B6
Authority
SK
Slovakia
Prior art keywords
process according
group
tert
substituted
compound
Prior art date
Application number
SK1478-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK147896A3 (en
Inventor
Ross A. Miller
Andrew S. Thompson
Raman K. Bakshi
Edward G. Corley
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SK147896A3 publication Critical patent/SK147896A3/sk
Publication of SK282278B6 publication Critical patent/SK282278B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/54—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
    • B01J23/56—Platinum group metals
    • B01J23/64—Platinum group metals with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
    • B01J23/652—Chromium, molybdenum or tungsten
    • B01J23/6527—Tungsten
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1478-96A 1994-05-19 1995-05-15 Spôsob oxidácie delta-5-steroidného alkénu SK282278B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24593594A 1994-05-19 1994-05-19
PCT/US1995/006004 WO1995032215A1 (en) 1994-05-19 1995-05-15 Oxidation of steroids having allylic groups

Publications (2)

Publication Number Publication Date
SK147896A3 SK147896A3 (en) 1997-08-06
SK282278B6 true SK282278B6 (sk) 2002-01-07

Family

ID=22928693

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1478-96A SK282278B6 (sk) 1994-05-19 1995-05-15 Spôsob oxidácie delta-5-steroidného alkénu

Country Status (23)

Country Link
US (1) US6369247B1 (zh)
EP (1) EP0759929B1 (zh)
JP (1) JPH10500682A (zh)
KR (1) KR970703359A (zh)
CN (1) CN1152316A (zh)
AT (1) ATE195741T1 (zh)
AU (1) AU688513B2 (zh)
BR (1) BR9507663A (zh)
CA (1) CA2190500A1 (zh)
CZ (1) CZ338896A3 (zh)
DE (1) DE69518515T2 (zh)
DK (1) DK0759929T3 (zh)
ES (1) ES2149365T3 (zh)
FI (1) FI964610A (zh)
GR (1) GR3034201T3 (zh)
HK (1) HK1009274A1 (zh)
HU (1) HU223613B1 (zh)
NZ (1) NZ287230A (zh)
PT (1) PT759929E (zh)
RO (1) RO116550B1 (zh)
RU (1) RU2149875C1 (zh)
SK (1) SK282278B6 (zh)
WO (1) WO1995032215A1 (zh)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763361A (en) * 1995-10-23 1998-06-09 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors
JPH11513711A (ja) * 1995-10-23 1999-11-24 メルク エンド カンパニー インコーポレーテッド １７−アルキル−７−置換−４−アザステロイド誘導体
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
US6686486B1 (en) 1997-05-07 2004-02-03 Padma Marwah Process for effecting allylic oxidation
US5869709A (en) * 1997-05-07 1999-02-09 Humanetics Corporation Process for effecting allylic oxidation
US6252119B1 (en) * 1997-07-28 2001-06-26 Salvador Jorge Antonio Riberiro Copper-catalysed allylic oxidation using alkyl hydroperoxide
US6187925B1 (en) 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
AU3088799A (en) 1998-03-18 1999-10-11 Humanetics Corporation Process for effecting allylic oxidation using dicarboxylic acid imides and chromium reagents
NZ515810A (en) 1999-04-30 2004-05-28 Arch Dev Corp Steroid derivatives
GB0020286D0 (en) * 2000-08-18 2000-10-04 Univ York Cobalt catalysed allylic oxidation of unsaturated steroids using alkyl hydroperoxide
DK1392713T3 (da) * 2001-05-03 2008-02-18 Univ Chicago Lever-X-receptoragonister
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
WO2003086303A2 (en) * 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
EP1898898A2 (en) * 2005-03-10 2008-03-19 Jr Chem, LLC Benzoyl peroxide compositions and methods of use
KR101352187B1 (ko) * 2005-03-10 2014-02-17 제이알 켐, 엘엘씨 안정한 유기 퍼옥사이드 조성물
US20090306023A1 (en) * 2005-06-29 2009-12-10 Ramirez Jose E Stable organic peroxide compositions
US7556820B2 (en) 2005-06-29 2009-07-07 Jr Chem, Llc Stable organic peroxide compositions
US20070001145A1 (en) * 2005-06-29 2007-01-04 Faryniarz Joseph R Stable organic peroxide compositions
WO2007002880A2 (en) * 2005-06-29 2007-01-04 Jr Chem, Llc Method of enhanced drug application
CN101619089B (zh) * 2009-07-28 2011-07-20 陈大刚 抗肿瘤药物cl168、其合成方法及应用
CA2769203A1 (en) * 2009-07-29 2011-02-03 University Of Chicago Liver x receptor agonists
KR101554402B1 (ko) * 2011-01-31 2015-09-18 아사히 가세이 케미칼즈 가부시키가이샤 혼합액 제조 장치 및 혼합액 조제 방법
WO2013101719A2 (en) 2011-12-27 2013-07-04 Northeast Ohio Medical University Amooranin compounds and analogs thereof and related methods of use
ES2693259T3 (es) * 2013-03-15 2018-12-10 The Florida State University Research Foundation, Incorporated Síntesis de ent-progesterona e intermedios de la misma
CN103788163B (zh) * 2014-01-27 2015-11-18 浙江大学 7-酮基甾类化合物的制备方法
ES2871130T3 (es) 2015-11-23 2021-10-28 Retrotope Inc Marcado isotópico específico del sitio de sistemas de 1, 4-dieno
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用
JP2023514711A (ja) 2020-02-21 2023-04-07 レトロトップ、 インコーポレイテッド 多価不飽和脂肪酸及びその誘導体の同位体修飾方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422443D0 (en) 1984-09-05 1984-10-10 British Petroleum Co Plc Oxidation of hydrocarbons
DK173704B1 (da) 1985-04-17 2001-07-09 Hoffmann La Roche Fremgangsmåde til katalytisk oxidation af allyliske grupper
RU94046044A (ru) 1992-05-20 1996-10-10 Мерк Энд Ко. Новые 7 бета -замещенные 4-аза- 5 альфа -холестан-оны в качестве ингибиторов 5 альфа -редуктазы, фармацевтическая композиция на их основе, способ ее получения
IL111467A0 (en) 1993-11-12 1994-12-29 Merck & Co Inc Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors

Also Published As

Publication number Publication date
DE69518515T2 (de) 2001-04-19
EP0759929A4 (en) 1998-09-30
PT759929E (pt) 2001-01-31
BR9507663A (pt) 1997-10-07
EP0759929B1 (en) 2000-08-23
CA2190500A1 (en) 1995-11-30
EP0759929A1 (en) 1997-03-05
ES2149365T3 (es) 2000-11-01
HUT75778A (en) 1997-05-28
HU9603187D0 (en) 1997-01-28
US6369247B1 (en) 2002-04-09
DE69518515D1 (de) 2000-09-28
SK147896A3 (en) 1997-08-06
HK1009274A1 (en) 1999-05-28
GR3034201T3 (en) 2000-11-30
RU2149875C1 (ru) 2000-05-27
FI964610A0 (fi) 1996-11-18
JPH10500682A (ja) 1998-01-20
HU223613B1 (hu) 2004-10-28
KR970703359A (ko) 1997-07-03
NZ287230A (en) 1997-07-27
AU2588595A (en) 1995-12-18
WO1995032215A1 (en) 1995-11-30
ATE195741T1 (de) 2000-09-15
FI964610A (fi) 1996-11-18
DK0759929T3 (da) 2000-11-13
AU688513B2 (en) 1998-03-12
RO116550B1 (ro) 2001-03-30
CN1152316A (zh) 1997-06-18
CZ338896A3 (en) 1997-07-16

Similar Documents

Publication Publication Date Title
SK282278B6 (sk) Spôsob oxidácie delta-5-steroidného alkénu
US5237064A (en) Process for producing 7β-substituted-aza-5αandrostan-3-ones
EP2513132B1 (en) Methods for the purification of deoxycholic acid
JPH0651718B2 (ja) アザステロイドに１，２二重結合を導入する方法
JPH0725791B2 (ja) 脱水素方法及び中間体
SK137994A3 (en) 7-beta-substituted-4-aza-5-alpha-cholestan-ons their using for production of pharmaceutical agent and pharmaceutical agent containing them
US5696266A (en) Process for the stereoselective reduction of steroid enelactams
US5219879A (en) Heterocyclic steroid compounds
CA2098146C (fr) Nouveau procede de preparation de composes steroides 20-ceto 21alpha-hydroxy et intermediaires
EP0528485A1 (en) 17Beta-acyl-3-androsta-3,5-dienes as testosterone 5alpha-reductase inhibitors
EP1558627B1 (en) Stereospecific reduction of sapogen-3-ones
JPS60252494A (ja) エストロゲン合成阻害剤
EP0523688A1 (en) Process for the preparation of 17beta-substituted-4-aza-5alpha-androstan-3-one derivatives
MXPA96005718A (en) Oxidation of steroids that have alili groups
US2741626A (en) Hydroxylated steroids
US3906096A (en) Novel 11{62 -alkoxy steroids
US3535350A (en) Process for the preparation of 13-alkyl gona-1,3,5(10),8,14-pentaen - 17 - ones from the corresponding 17-ols
CH508610A (fr) Procédé de préparation de 7ä-méthyl gona-4,9-diènes substitués
SK13252001A3 (sk) Spôsob prípravy esterov kyseliny 4,4-dimetyl-3beta- hydroxypregna-8,14-dién-21-karboxylovej, ich použitie a medziprodukty získané pri tejto príprave
JPH02207096A (ja) ２１―アシルオキシ―２０―ケト―△↑１↑６―ステロイドの製造法