ATE195741T1 - Oxidation von steroiden mit allylischen gruppen - Google Patents

Oxidation von steroiden mit allylischen gruppen

Info

Publication number
ATE195741T1
ATE195741T1 AT95920434T AT95920434T ATE195741T1 AT E195741 T1 ATE195741 T1 AT E195741T1 AT 95920434 T AT95920434 T AT 95920434T AT 95920434 T AT95920434 T AT 95920434T AT E195741 T1 ATE195741 T1 AT E195741T1
Authority
AT
Austria
Prior art keywords
allylic
steroids
oxidation
allylic groups
delta
Prior art date
Application number
AT95920434T
Other languages
English (en)
Inventor
Ross A Miller
Andrew S Thompson
Raman K Bakshi
Edward G Corley
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE195741T1 publication Critical patent/ATE195741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46—Ruthenium, rhodium, osmium or iridium
    • B01J23/462—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/54—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals combined with metals, oxides or hydroxides provided for in groups B01J23/02 - B01J23/36
    • B01J23/56—Platinum group metals
    • B01J23/64—Platinum group metals with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
    • B01J23/652—Chromium, molybdenum or tungsten
    • B01J23/6527—Tungsten
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920434T 1994-05-19 1995-05-15 Oxidation von steroiden mit allylischen gruppen ATE195741T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24593594A 1994-05-19 1994-05-19
PCT/US1995/006004 WO1995032215A1 (en) 1994-05-19 1995-05-15 Oxidation of steroids having allylic groups

Publications (1)

Publication Number Publication Date
ATE195741T1 true ATE195741T1 (de) 2000-09-15

Family

ID=22928693

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920434T ATE195741T1 (de) 1994-05-19 1995-05-15 Oxidation von steroiden mit allylischen gruppen

Country Status (23)

Country Link
US (1) US6369247B1 (de)
EP (1) EP0759929B1 (de)
JP (1) JPH10500682A (de)
KR (1) KR970703359A (de)
CN (1) CN1152316A (de)
AT (1) ATE195741T1 (de)
AU (1) AU688513B2 (de)
BR (1) BR9507663A (de)
CA (1) CA2190500A1 (de)
CZ (1) CZ338896A3 (de)
DE (1) DE69518515T2 (de)
DK (1) DK0759929T3 (de)
ES (1) ES2149365T3 (de)
FI (1) FI964610A0 (de)
GR (1) GR3034201T3 (de)
HK (1) HK1009274A1 (de)
HU (1) HU223613B1 (de)
NZ (1) NZ287230A (de)
PT (1) PT759929E (de)
RO (1) RO116550B1 (de)
RU (1) RU2149875C1 (de)
SK (1) SK282278B6 (de)
WO (1) WO1995032215A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763361A (en) * 1995-10-23 1998-06-09 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors
DE69615046T2 (de) * 1995-10-23 2002-06-27 Merck & Co., Inc. 17-alkyl-7-substituierte-4-aza-steroidderivate
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
US6686486B1 (en) 1997-05-07 2004-02-03 Padma Marwah Process for effecting allylic oxidation
US5869709A (en) * 1997-05-07 1999-02-09 Humanetics Corporation Process for effecting allylic oxidation
US6252119B1 (en) * 1997-07-28 2001-06-26 Salvador Jorge Antonio Riberiro Copper-catalysed allylic oxidation using alkyl hydroperoxide
US6187925B1 (en) 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
AU3088799A (en) 1998-03-18 1999-10-11 Humanetics Corporation Process for effecting allylic oxidation using dicarboxylic acid imides and chromium reagents
CA2372493A1 (en) 1999-04-30 2000-11-09 Arch Development Corporation Steroid derivatives
GB0020286D0 (en) * 2000-08-18 2000-10-04 Univ York Cobalt catalysed allylic oxidation of unsaturated steroids using alkyl hydroperoxide
CA2446314C (en) * 2001-05-03 2011-02-22 The University Of Chicago Liver x receptor agonists
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
EP1494533A2 (de) * 2002-04-12 2005-01-12 The University of Chicago Farnesoid-x-aktivierte rezeptoragonisten
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
JP5155849B2 (ja) * 2005-03-10 2013-03-06 ジェイアール ケム エルエルシー 安定性有機過酸化物組成物
US20060204530A1 (en) * 2005-03-10 2006-09-14 Jr Chem, Llc Benzoyl peroxide compositions and methods of use
US20070044810A1 (en) * 2005-06-29 2007-03-01 Jr Chem, Llc Method of enhanced drug application
US20090306023A1 (en) * 2005-06-29 2009-12-10 Ramirez Jose E Stable organic peroxide compositions
WO2007005471A2 (en) * 2005-06-29 2007-01-11 Jr Chem, Llc Stable organic peroxide compositions
US7556820B2 (en) 2005-06-29 2009-07-07 Jr Chem, Llc Stable organic peroxide compositions
CN101619089B (zh) * 2009-07-28 2011-07-20 陈大刚 抗肿瘤药物cl168、其合成方法及应用
WO2011014661A2 (en) * 2009-07-29 2011-02-03 The University Of Chicago Liver x receptor agonists
US9561479B2 (en) * 2011-01-31 2017-02-07 Asahi Kasei Chemicals Corporation Apparatus for producing mixed solution and method for preparing mixed solution
WO2013101719A2 (en) 2011-12-27 2013-07-04 Northeast Ohio Medical University Amooranin compounds and analogs thereof and related methods of use
KR20160058722A (ko) * 2013-03-15 2016-05-25 더 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 ent-프로게스테론 및 그의 중간생성물의 합성
CN103788163B (zh) * 2014-01-27 2015-11-18 浙江大学 7-酮基甾类化合物的制备方法
WO2017091279A1 (en) 2015-11-23 2017-06-01 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用
WO2021168311A1 (en) 2020-02-21 2021-08-26 Retrotope, Inc. Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422443D0 (en) * 1984-09-05 1984-10-10 British Petroleum Co Plc Oxidation of hydrocarbons
DK173704B1 (da) 1985-04-17 2001-07-09 Hoffmann La Roche Fremgangsmåde til katalytisk oxidation af allyliske grupper
WO1993023419A1 (en) 1992-05-20 1993-11-25 Merck & Co., Inc. NEW 7β-SUBSTITUTED-4-AZA-5α-CHOLESTAN-ONES AS 5α-REDUCTASE INHIBITORS
IL111467A0 (en) 1993-11-12 1994-12-29 Merck & Co Inc Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors

Also Published As

Publication number Publication date
KR970703359A (ko) 1997-07-03
HU9603187D0 (en) 1997-01-28
NZ287230A (en) 1997-07-27
RU2149875C1 (ru) 2000-05-27
WO1995032215A1 (en) 1995-11-30
HUT75778A (en) 1997-05-28
CZ338896A3 (en) 1997-07-16
CA2190500A1 (en) 1995-11-30
SK282278B6 (sk) 2002-01-07
HU223613B1 (hu) 2004-10-28
DE69518515D1 (de) 2000-09-28
CN1152316A (zh) 1997-06-18
FI964610A (fi) 1996-11-18
DE69518515T2 (de) 2001-04-19
DK0759929T3 (da) 2000-11-13
EP0759929A1 (de) 1997-03-05
AU2588595A (en) 1995-12-18
ES2149365T3 (es) 2000-11-01
EP0759929A4 (de) 1998-09-30
RO116550B1 (ro) 2001-03-30
JPH10500682A (ja) 1998-01-20
GR3034201T3 (en) 2000-11-30
SK147896A3 (en) 1997-08-06
BR9507663A (pt) 1997-10-07
AU688513B2 (en) 1998-03-12
PT759929E (pt) 2001-01-31
EP0759929B1 (de) 2000-08-23
FI964610A0 (fi) 1996-11-18
US6369247B1 (en) 2002-04-09
HK1009274A1 (en) 1999-05-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee