SK282144B6 - Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom - Google Patents

Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom Download PDF

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Publication number
SK282144B6
SK282144B6 SK856-97A SK85697A SK282144B6 SK 282144 B6 SK282144 B6 SK 282144B6 SK 85697 A SK85697 A SK 85697A SK 282144 B6 SK282144 B6 SK 282144B6
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SK
Slovakia
Prior art keywords
derivatives
vascular
nebivolol
therapeutic
compound
Prior art date
Application number
SK856-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK85697A3 (en
Inventor
Chaffoy De Courcelles Didier Robert Guy Gabriel De
Anne Simone Josephine Lesage
Josepha Eduarda Maria Francisca Leysen
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK85697A3 publication Critical patent/SK85697A3/sk
Publication of SK282144B6 publication Critical patent/SK282144B6/sk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
SK856-97A 1994-12-28 1995-12-21 Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom SK282144B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203775 1994-12-28
PCT/EP1995/005174 WO1996019987A1 (en) 1994-12-28 1995-12-21 Use of nebivolol as an anti-atherogenic

Publications (2)

Publication Number Publication Date
SK85697A3 SK85697A3 (en) 2000-04-10
SK282144B6 true SK282144B6 (sk) 2001-11-06

Family

ID=8217503

Family Applications (1)

Application Number Title Priority Date Filing Date
SK856-97A SK282144B6 (sk) 1994-12-28 1995-12-21 Liečivo na terapeutické a profylaktické ošetrenie degeneratívnych chorôb vaskulárneho systému a nervovej sústavy, ktoré súvisia s oxidačným stresom

Country Status (20)

Country Link
US (2) US5874461A (hu)
EP (1) EP0801564B1 (hu)
JP (1) JPH10511655A (hu)
KR (1) KR100264348B1 (hu)
CN (1) CN1167418C (hu)
AT (1) ATE214924T1 (hu)
AU (1) AU700364B2 (hu)
CA (1) CA2207333C (hu)
CZ (1) CZ287513B6 (hu)
DE (1) DE69526120T2 (hu)
DK (1) DK0801564T3 (hu)
ES (1) ES2176354T3 (hu)
FI (1) FI118884B (hu)
HU (1) HU226208B1 (hu)
NO (1) NO315687B1 (hu)
NZ (1) NZ298074A (hu)
PT (1) PT801564E (hu)
SI (1) SI0801564T1 (hu)
SK (1) SK282144B6 (hu)
WO (1) WO1996019987A1 (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0801564B1 (en) * 1994-12-28 2002-03-27 Janssen Pharmaceutica N.V. Use of nebivolol as an anti-atherogenic
DE19716120A1 (de) * 1997-04-17 1998-10-22 Europ Lab Molekularbiolog Verwendung von cholesterinsenkenden Mitteln
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
JP2000207219A (ja) * 1999-01-18 2000-07-28 Fujitsu Ten Ltd 車載端末とセンタ―との間の通信システム、及び、通信システムに使用する車載端末
US6593497B1 (en) 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
UA73965C2 (en) 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
JP2004528337A (ja) 2001-05-02 2004-09-16 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法
EP1558922B1 (en) * 2002-10-30 2013-02-27 Ampere Life Sciences, Inc. Identifying therapeutic compounds based on their physical-chemical properties
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7470798B2 (en) 2003-09-19 2008-12-30 Edison Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
EP1737847B1 (en) 2004-07-30 2008-06-04 Torrent Pharmaceuticals Ltd Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
NZ560386A (en) * 2005-01-31 2009-12-24 Mylan Lab Inc Pharmaceutical composition comprising hydroxylated nebivolol
DK1888059T3 (en) 2005-06-01 2015-03-30 Edison Pharmaceuticals Inc Redox-active therapeutic products for the treatment of mitochondrial diseases and other conditions as well as modulation of energy biomarkers
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
EP3018122B1 (en) 2007-11-06 2018-10-10 BioElectron Technology Corporation 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
US20090181975A1 (en) * 2008-01-15 2009-07-16 Forest Laboratories Holdings Limited Nebivolol in the treatment of sexual dysfunction
JP5710277B2 (ja) 2008-03-05 2015-04-30 エジソン ファーマシューティカルズ, インコーポレイテッド 酸化ストレス疾患の処置のための2−置換−p−キノン誘導体
EP2344142B1 (en) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
EP2362726B1 (en) 2008-10-14 2018-08-08 Bioelectron Technology Corporation Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
SG172275A1 (en) * 2008-12-19 2011-07-28 Schering Corp Feed supplement for mammalian cell culture and methods of use
BRPI1013376A8 (pt) 2009-04-28 2017-07-11 Edison Pharmaceuticals Inc Uso de quinonas de tocotrienol,preparação farmacêutica compreendendo as ditas quinonas e uso desta
CN103037839A (zh) * 2010-06-04 2013-04-10 全球药物科技有限公司 含有矫味剂的口服美其敏水性制剂
US9296712B2 (en) 2013-03-15 2016-03-29 Edison Pharmaceuticals, Inc. Resorufin derivatives for treatment of oxidative stress disorders
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
TW201615221A (zh) * 2014-10-24 2016-05-01 朗齊生物醫學股份有限公司 炎症用藥臨床新應用
EP3233786B1 (en) 2014-12-16 2022-03-16 PTC Therapeutics, Inc. Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
US10703701B2 (en) 2015-12-17 2020-07-07 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
EP0801564B1 (en) * 1994-12-28 2002-03-27 Janssen Pharmaceutica N.V. Use of nebivolol as an anti-atherogenic

Also Published As

Publication number Publication date
WO1996019987A1 (en) 1996-07-04
US5874461A (en) 1999-02-23
US6075046A (en) 2000-06-13
CN1167418C (zh) 2004-09-22
SI0801564T1 (en) 2002-08-31
SK85697A3 (en) 2000-04-10
EP0801564A1 (en) 1997-10-22
CZ191997A3 (cs) 1999-01-13
ES2176354T3 (es) 2002-12-01
MX9704669A (es) 1997-09-30
CN1171739A (zh) 1998-01-28
DK0801564T3 (da) 2002-07-15
NO972980D0 (no) 1997-06-26
EP0801564B1 (en) 2002-03-27
NO315687B1 (no) 2003-10-13
DE69526120T2 (de) 2002-11-28
ATE214924T1 (de) 2002-04-15
NZ298074A (en) 2001-01-26
NO972980L (no) 1997-06-26
CZ287513B6 (en) 2000-12-13
KR100264348B1 (ko) 2000-08-16
CA2207333A1 (en) 1996-07-04
CA2207333C (en) 2006-10-17
JPH10511655A (ja) 1998-11-10
HU226208B1 (en) 2008-06-30
DE69526120D1 (de) 2002-05-02
FI972793A (fi) 1997-06-27
HUT77927A (hu) 1998-11-30
FI118884B (fi) 2008-04-30
FI972793A0 (fi) 1997-06-27
AU4347796A (en) 1996-07-19
AU700364B2 (en) 1999-01-07
PT801564E (pt) 2002-09-30

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Expiry date: 20151221