SK281302B6 - Amidové deriváty vitamínu d, spôsob ich výroby, ich použitie a farmaceutické kompozície s ich obsahom - Google Patents
Amidové deriváty vitamínu d, spôsob ich výroby, ich použitie a farmaceutické kompozície s ich obsahom Download PDFInfo
- Publication number
- SK281302B6 SK281302B6 SK522-94A SK52294A SK281302B6 SK 281302 B6 SK281302 B6 SK 281302B6 SK 52294 A SK52294 A SK 52294A SK 281302 B6 SK281302 B6 SK 281302B6
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- Slovakia
- Prior art keywords
- group
- formula
- dihydroxy
- compound
- compounds
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- 238000000034 method Methods 0.000 title claims description 14
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919123712A GB9123712D0 (en) | 1991-11-07 | 1991-11-07 | Chemical compounds |
| GB929209658A GB9209658D0 (en) | 1992-05-05 | 1992-05-05 | Chemical compounds |
| PCT/EP1992/002577 WO1993009093A1 (en) | 1991-11-07 | 1992-11-06 | Vitamin d amide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK52294A3 SK52294A3 (en) | 1994-11-09 |
| SK281302B6 true SK281302B6 (sk) | 2001-02-12 |
Family
ID=26299825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK522-94A SK281302B6 (sk) | 1991-11-07 | 1992-11-06 | Amidové deriváty vitamínu d, spôsob ich výroby, ich použitie a farmaceutické kompozície s ich obsahom |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5494905A (cs) |
| EP (1) | EP0614455B1 (cs) |
| JP (1) | JP3282811B2 (cs) |
| KR (1) | KR100271461B1 (cs) |
| AT (1) | ATE134366T1 (cs) |
| AU (1) | AU664213B2 (cs) |
| CA (1) | CA2121678C (cs) |
| CZ (1) | CZ288031B6 (cs) |
| DE (1) | DE69208478T2 (cs) |
| DK (1) | DK0614455T3 (cs) |
| ES (1) | ES2083771T3 (cs) |
| FI (1) | FI106119B (cs) |
| GR (1) | GR3019601T3 (cs) |
| HU (1) | HU221008B1 (cs) |
| NO (1) | NO305315B1 (cs) |
| NZ (1) | NZ245041A (cs) |
| PL (1) | PL171580B1 (cs) |
| RU (1) | RU2139276C1 (cs) |
| SK (1) | SK281302B6 (cs) |
| WO (1) | WO1993009093A1 (cs) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2083771T3 (es) * | 1991-11-07 | 1996-04-16 | Res Inst Medicine Chem | Derivados amidicos de la vitamina d. |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| WO2004076688A1 (ja) * | 1993-02-12 | 2004-09-10 | Etsuro Ogata | 無症候腎障害のモニタリング法 |
| GB9309422D0 (en) * | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
| GB9325415D0 (en) * | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
| GB9405715D0 (en) * | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
| US5661141A (en) * | 1995-03-27 | 1997-08-26 | Petrow; Vladimir | 19-oxygenated steroids as therapeutic agents |
| US5678570A (en) * | 1995-04-14 | 1997-10-21 | The University Of North Carolina At Chapel Hill | Method of treating cardiac arrest |
| US5696103A (en) * | 1995-11-17 | 1997-12-09 | Syntex (U.S.A.) Inc. | Method for treating osteoporosis |
| DE19619036A1 (de) * | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6043385A (en) * | 1997-12-16 | 2000-03-28 | Hoffman-La Roche Inc. | Vitamin D derivatives |
| GB9804861D0 (en) | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| AU758792B2 (en) * | 1998-10-23 | 2003-03-27 | Teijin Limited | Vitamin D3 derivatives and remedies for inflammatory respiratory diseases containing the same |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| WO2001022974A1 (en) | 1999-09-29 | 2001-04-05 | Colotech A/S | Prevention of colorectal cancer |
| US6703380B2 (en) | 1999-09-29 | 2004-03-09 | Colotech A/S | Prevention of cancer |
| WO2001030751A2 (en) * | 1999-10-25 | 2001-05-03 | Strakan Limited | USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF |
| EP1295871B1 (en) | 2000-06-15 | 2011-05-18 | Chugai Seiyaku Kabushiki Kaisha | Vitamin d derivatives possessing a 22-oxa or 22-thia atom, a c17-side chain substituted by an acid, ester or amide group and a 16(17)-double bond |
| US20080293647A1 (en) | 2004-11-12 | 2008-11-27 | Luciano Adorini | Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer |
| EP2018366A4 (en) * | 2006-05-16 | 2010-08-04 | Univ Mcgill | HYBRID MOLECULES WITH MIXED VITAMIN D RECEPTOR AGONISM AND HISTONDEACETYLASE RESISTANT PROPERTIES |
| WO2009117831A1 (en) * | 2008-03-27 | 2009-10-01 | The Royal Institution For The Advancement Of Learning/Mcgill University | Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties |
| WO2012158794A1 (en) | 2011-05-17 | 2012-11-22 | Wisconsin Alumni Research Foundation | N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses |
| TW202227396A (zh) * | 2020-09-15 | 2022-07-16 | 日商帝人製藥股份有限公司 | 於側鏈具有環狀胺之維他命ｄ衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217288A (en) * | 1977-03-24 | 1980-08-12 | Wisconsin Alumni Research Foundation | Anti-vitamin D compounds |
| NL7903929A (nl) * | 1978-05-19 | 1979-11-21 | Wisconsin Alumni Res Found | Verbindingen met anti-vitamine d activiteit, farmaceutisch preparaat, dat een dergelijke verbinding bevat, alsmede werkwijze voor de toepassing van dergelijke verbindingen. |
| DE3869692D1 (de) * | 1987-07-29 | 1992-05-07 | Takeda Chemical Industries Ltd | Zellproliferationsinhibitor. |
| US5206230A (en) * | 1991-06-05 | 1993-04-27 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same |
| ES2083771T3 (es) * | 1991-11-07 | 1996-04-16 | Res Inst Medicine Chem | Derivados amidicos de la vitamina d. |
-
1992
- 1992-11-06 ES ES92922932T patent/ES2083771T3/es not_active Expired - Lifetime
- 1992-11-06 HU HU9401372A patent/HU221008B1/hu not_active IP Right Cessation
- 1992-11-06 AT AT92922932T patent/ATE134366T1/de not_active IP Right Cessation
- 1992-11-06 SK SK522-94A patent/SK281302B6/sk unknown
- 1992-11-06 WO PCT/EP1992/002577 patent/WO1993009093A1/en active IP Right Grant
- 1992-11-06 CZ CZ19941112A patent/CZ288031B6/cs not_active IP Right Cessation
- 1992-11-06 PL PL92303505A patent/PL171580B1/pl not_active IP Right Cessation
- 1992-11-06 DE DE69208478T patent/DE69208478T2/de not_active Expired - Fee Related
- 1992-11-06 KR KR1019940701503A patent/KR100271461B1/ko not_active Expired - Fee Related
- 1992-11-06 EP EP92922932A patent/EP0614455B1/en not_active Expired - Lifetime
- 1992-11-06 AU AU29014/92A patent/AU664213B2/en not_active Ceased
- 1992-11-06 JP JP50817993A patent/JP3282811B2/ja not_active Expired - Fee Related
- 1992-11-06 RU RU94044435A patent/RU2139276C1/ru not_active IP Right Cessation
- 1992-11-06 CA CA002121678A patent/CA2121678C/en not_active Expired - Fee Related
- 1992-11-06 DK DK92922932.6T patent/DK0614455T3/da active
- 1992-11-06 NZ NZ245041A patent/NZ245041A/en not_active IP Right Cessation
- 1992-11-06 US US08/211,722 patent/US5494905A/en not_active Expired - Fee Related
-
1994
- 1994-05-06 NO NO941683A patent/NO305315B1/no unknown
- 1994-05-06 FI FI942114A patent/FI106119B/fi not_active IP Right Cessation
-
1995
- 1995-12-07 US US08/568,755 patent/US5686435A/en not_active Expired - Fee Related
-
1996
- 1996-04-09 GR GR960400996T patent/GR3019601T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ245041A (en) | 1995-03-28 |
| CZ111294A3 (en) | 1995-03-15 |
| CZ288031B6 (cs) | 2001-04-11 |
| SK52294A3 (en) | 1994-11-09 |
| WO1993009093A1 (en) | 1993-05-13 |
| JPH07502499A (ja) | 1995-03-16 |
| HU9401372D0 (en) | 1994-08-29 |
| HU221008B1 (hu) | 2002-07-29 |
| FI942114L (fi) | 1994-05-06 |
| US5494905A (en) | 1996-02-27 |
| EP0614455B1 (en) | 1996-02-21 |
| NO305315B1 (no) | 1999-05-10 |
| DE69208478D1 (de) | 1996-03-28 |
| HUT67140A (en) | 1995-02-28 |
| DE69208478T2 (de) | 1996-09-05 |
| CA2121678A1 (en) | 1993-05-13 |
| ATE134366T1 (de) | 1996-03-15 |
| NO941683D0 (no) | 1994-05-06 |
| DK0614455T3 (da) | 1996-03-18 |
| KR100271461B1 (ko) | 2000-11-15 |
| PL171580B1 (pl) | 1997-05-30 |
| ES2083771T3 (es) | 1996-04-16 |
| AU664213B2 (en) | 1995-11-09 |
| US5686435A (en) | 1997-11-11 |
| FI106119B (fi) | 2000-11-30 |
| EP0614455A1 (en) | 1994-09-14 |
| JP3282811B2 (ja) | 2002-05-20 |
| FI942114A0 (fi) | 1994-05-06 |
| RU2139276C1 (ru) | 1999-10-10 |
| CA2121678C (en) | 2005-03-15 |
| NO941683L (cs) | 1994-06-27 |
| GR3019601T3 (en) | 1996-07-31 |
| AU2901492A (en) | 1993-06-07 |
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