ES2083771T3 - Derivados amidicos de la vitamina d. - Google Patents

Derivados amidicos de la vitamina d.

Info

Publication number
ES2083771T3
ES2083771T3 ES92922932T ES92922932T ES2083771T3 ES 2083771 T3 ES2083771 T3 ES 2083771T3 ES 92922932 T ES92922932 T ES 92922932T ES 92922932 T ES92922932 T ES 92922932T ES 2083771 T3 ES2083771 T3 ES 2083771T3
Authority
ES
Spain
Prior art keywords
vitamin
alpha
amidic derivatives
amidic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922932T
Other languages
English (en)
Inventor
Robert Henry Hesse
Gaddam Subba Reddy
Sundara Katugam Srinivas Setty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919123712A external-priority patent/GB9123712D0/en
Priority claimed from GB929209658A external-priority patent/GB9209658D0/en
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Application granted granted Critical
Publication of ES2083771T3 publication Critical patent/ES2083771T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

SE DESCRIBEN UNOS NUEVOS DERIVADOS 1 -HIDROXI DE VITAMINA D Y SUS ANALOGOS 20-EPI, QUE COMPRENDEN UNOS COMPUESTOS DE FORMULA (I) Y LOS CORRESPONDIENTES TRANSISOMEROS-5,6 EN LA QUE Y REPRESENTA UN GRUPO ALQUILENO O ALQUENILENO DE MAS DE 4 ATOMOS DE CARBONO; R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR O CICLOALQUILO; O R1R2NREPRESENTA UN GRUPO HETEROCICLICO; R3 Y R4 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR-O. LOS COMPONENTES ACTIVOS EN LOS QUE R3 Y R4 SON ATOMOS DE HIDROGENO O GRUPOS PROTECTORES-O METABOLICAMENTE ADECUADOS, EXHIBEN UN POTENTE EFECTO MODULADOR DE CELULAS CON UN MINIMO EFECTO SOBRE METABOLISMO DE CALCIO.
ES92922932T 1991-11-07 1992-11-06 Derivados amidicos de la vitamina d. Expired - Lifetime ES2083771T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919123712A GB9123712D0 (en) 1991-11-07 1991-11-07 Chemical compounds
GB929209658A GB9209658D0 (en) 1992-05-05 1992-05-05 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2083771T3 true ES2083771T3 (es) 1996-04-16

Family

ID=26299825

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922932T Expired - Lifetime ES2083771T3 (es) 1991-11-07 1992-11-06 Derivados amidicos de la vitamina d.

Country Status (20)

Country Link
US (2) US5494905A (es)
EP (1) EP0614455B1 (es)
JP (1) JP3282811B2 (es)
KR (1) KR100271461B1 (es)
AT (1) ATE134366T1 (es)
AU (1) AU664213B2 (es)
CA (1) CA2121678C (es)
CZ (1) CZ288031B6 (es)
DE (1) DE69208478T2 (es)
DK (1) DK0614455T3 (es)
ES (1) ES2083771T3 (es)
FI (1) FI106119B (es)
GR (1) GR3019601T3 (es)
HU (1) HU221008B1 (es)
NO (1) NO305315B1 (es)
NZ (1) NZ245041A (es)
PL (1) PL171580B1 (es)
RU (1) RU2139276C1 (es)
SK (1) SK281302B6 (es)
WO (1) WO1993009093A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL171580B1 (pl) * 1991-11-07 1997-05-30 Res Inst Medicine Chem Sposób wytwarzania nowych analogów witaminy D3 PL PL PL
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US5662604A (en) * 1993-02-12 1997-09-02 Asahi Kasei Kogyo Kabushiki Kaisha Monitoring method of renal lesions without clinical signs
GB9309422D0 (en) * 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
GB9325415D0 (en) * 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
GB9405715D0 (en) * 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US5678570A (en) * 1995-04-14 1997-10-21 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
DE19619036A1 (de) * 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6043385A (en) * 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
GB9804861D0 (en) 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
KR100676106B1 (ko) * 1998-10-23 2007-02-28 데이진 가부시키가이샤 비타민 ｄ3 유도체 및 그것을 사용하는 염증성 호흡기질환 치료제
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO2001022974A1 (en) 1999-09-29 2001-04-05 Colotech A/S Prevention of colorectal cancer
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
WO2001030751A2 (en) * 1999-10-25 2001-05-03 Strakan Limited USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
US7985744B2 (en) * 2000-06-15 2011-07-26 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivatives
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
US20100016435A1 (en) * 2006-05-16 2010-01-21 Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties
WO2009117831A1 (en) * 2008-03-27 2009-10-01 The Royal Institution For The Advancement Of Learning/Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties
US8987235B2 (en) 2011-05-17 2015-03-24 Wisconsin Alumni Research Foundation N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
US20230348376A1 (en) * 2020-09-15 2023-11-02 Teijin Pharma Limited Vitamin d derivative having cyclic amine in side chain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217288A (en) * 1977-03-24 1980-08-12 Wisconsin Alumni Research Foundation Anti-vitamin D compounds
GB2021115B (en) * 1978-05-19 1982-10-06 Wisconsin Alumni Res Found Vitamin d derivatives
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
PL171580B1 (pl) * 1991-11-07 1997-05-30 Res Inst Medicine Chem Sposób wytwarzania nowych analogów witaminy D3 PL PL PL

Also Published As

Publication number Publication date
CZ111294A3 (en) 1995-03-15
ATE134366T1 (de) 1996-03-15
US5494905A (en) 1996-02-27
PL171580B1 (pl) 1997-05-30
US5686435A (en) 1997-11-11
FI106119B (fi) 2000-11-30
DE69208478T2 (de) 1996-09-05
DE69208478D1 (de) 1996-03-28
HUT67140A (en) 1995-02-28
EP0614455A1 (en) 1994-09-14
HU9401372D0 (en) 1994-08-29
NZ245041A (en) 1995-03-28
AU2901492A (en) 1993-06-07
WO1993009093A1 (en) 1993-05-13
DK0614455T3 (da) 1996-03-18
GR3019601T3 (en) 1996-07-31
KR100271461B1 (ko) 2000-11-15
FI942114A (fi) 1994-05-06
SK52294A3 (en) 1994-11-09
CZ288031B6 (cs) 2001-04-11
JP3282811B2 (ja) 2002-05-20
SK281302B6 (sk) 2001-02-12
NO305315B1 (no) 1999-05-10
CA2121678C (en) 2005-03-15
FI942114A0 (fi) 1994-05-06
NO941683D0 (no) 1994-05-06
AU664213B2 (en) 1995-11-09
JPH07502499A (ja) 1995-03-16
CA2121678A1 (en) 1993-05-13
RU2139276C1 (ru) 1999-10-10
NO941683L (es) 1994-06-27
HU221008B1 (hu) 2002-07-29
EP0614455B1 (en) 1996-02-21

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