SK280812B6 - 1,3-substituované cykloalkány a 1,3-substituované cykloalkény, spôsoby ich prípravy a farmaceutické prípravky na ich báze - Google Patents

1,3-substituované cykloalkány a 1,3-substituované cykloalkény, spôsoby ich prípravy a farmaceutické prípravky na ich báze Download PDF

Info

Publication number
SK280812B6
SK280812B6 SK569-94A SK56994A SK280812B6 SK 280812 B6 SK280812 B6 SK 280812B6 SK 56994 A SK56994 A SK 56994A SK 280812 B6 SK280812 B6 SK 280812B6
Authority
SK
Slovakia
Prior art keywords
substituted
phenyl
cyclohexen
halogen
methyl
Prior art date
Application number
SK569-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK56994A3 (en
Inventor
Bradley William Caprathe
Dennis Michael Downing
Juan Carlos Jaen
Stephen Joseph Johnson
William John Smith Iii
Lawrence David Wise
Jonathan Wright
David Juergen Wustrow
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK56994A3 publication Critical patent/SK56994A3/sk
Publication of SK280812B6 publication Critical patent/SK280812B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Luminescent Compositions (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK569-94A 1991-11-20 1992-11-05 1,3-substituované cykloalkány a 1,3-substituované cykloalkény, spôsoby ich prípravy a farmaceutické prípravky na ich báze SK280812B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79520791A 1991-11-20 1991-11-20
US07/957,277 US5314896A (en) 1991-11-20 1992-10-15 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
PCT/US1992/009583 WO1993010092A1 (en) 1991-11-20 1992-11-05 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents

Publications (2)

Publication Number Publication Date
SK56994A3 SK56994A3 (en) 1995-02-08
SK280812B6 true SK280812B6 (sk) 2000-08-14

Family

ID=27121601

Family Applications (1)

Application Number Title Priority Date Filing Date
SK569-94A SK280812B6 (sk) 1991-11-20 1992-11-05 1,3-substituované cykloalkány a 1,3-substituované cykloalkény, spôsoby ich prípravy a farmaceutické prípravky na ich báze

Country Status (20)

Country Link
US (2) US5314896A (hu)
EP (2) EP0613465B1 (hu)
JP (1) JP3193718B2 (hu)
KR (1) KR100234600B1 (hu)
AT (1) ATE206398T1 (hu)
AU (1) AU664872B2 (hu)
CA (1) CA2122911C (hu)
CZ (1) CZ284181B6 (hu)
DE (1) DE69232099T2 (hu)
DK (1) DK0613465T3 (hu)
ES (1) ES2165360T3 (hu)
FI (2) FI106259B (hu)
HU (1) HU218935B (hu)
NO (1) NO180632C (hu)
NZ (1) NZ245174A (hu)
PT (1) PT613465E (hu)
RU (1) RU2116297C1 (hu)
SG (1) SG46641A1 (hu)
SK (1) SK280812B6 (hu)
WO (1) WO1993010092A1 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401692A (en) * 1993-06-15 1995-03-28 Texas Instruments Incorporated Method for minimizing particle generation on a wafer surface during high pressure oxidation of silicon
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
US5710277A (en) * 1994-09-12 1998-01-20 Warner-Lambert Company Process for R (+) 1,2,3,6-tetrahydro-4-phenyl-1- (3-phenyl-3-cyclohexen-1-yl)methyl!pyridine, a central nervous system agent
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
JP3332929B2 (ja) * 1995-02-15 2002-10-07 ニューロゲン コーポレイション ある種の架橋４−フェニル−２−アミノメチルイミダゾール：新しいドパミン受容体サブタイプ特異的リガンド
CN1184478A (zh) * 1995-03-22 1998-06-10 大正制药株式会社 噻唑衍生物
US5656632A (en) * 1995-06-05 1997-08-12 Neurogen Corporation 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands
US6245768B1 (en) 1995-06-05 2001-06-12 Neurogen Corporation 1-(N′-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
US5602168A (en) * 1995-07-10 1997-02-11 Neurogen Corporation 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
PT1068184E (pt) * 1998-04-08 2002-12-31 Wyeth Corp Derivados n-ariloxietilamina para o tratamento de depressao
US6313126B1 (en) 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
JP2002534426A (ja) * 1999-01-07 2002-10-15 ワイス 鬱病の処置のための新規な１，４−二基置換されたシクロヘキサン誘導体
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
US6245780B1 (en) * 1999-04-22 2001-06-12 American Home Products Corp Tetrahydroisoquinolinyl-indole derivatives for the treatment of depression
SI1212320T1 (en) 1999-08-23 2005-10-31 Solvay Pharmaceuticals B.V. Phenylpiperazines as serotonin reuptake inhibitors
US6780305B2 (en) * 2001-02-20 2004-08-24 Fuji Photo Film Co., Ltd. Method for producing support for planographic printing plate, support for planographic printing plate, and planographic printing plate precursor
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US20040197284A1 (en) 2003-04-04 2004-10-07 Frederic Auguste Cosmetic composition comprising a volatile fatty phase
AR047759A1 (es) 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
RU2009128062A (ru) * 2006-12-21 2011-01-27 Эбботт Лэборетриз (Us) Соединения агонисты и антагонисты рецептора сфингозин-1-фосфата
US8217027B2 (en) 2006-12-21 2012-07-10 Abbott Laboratories Sphingosine-1-phosphate receptor agonist and antagonist compounds
MX2009006748A (es) 2006-12-21 2009-06-30 Abbott Lab Proceso para la preparacion y aislamiento de los estereoisomeros individuales de fenilciclopentan-carboxilatos 3-sustituidos de 1-amino.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4597921A (en) * 1984-07-26 1986-07-01 Northern Telecom Limited Provision of plastic insulation upon an electrical conductor
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US4957921A (en) * 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US4975445A (en) * 1989-12-06 1990-12-04 Warner-Lambert Company Substituted cyclohexenes as central nervous system agents
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents

Also Published As

Publication number Publication date
DE69232099T2 (de) 2002-06-06
NZ245174A (en) 1995-09-26
CA2122911C (en) 2003-10-14
US5409931A (en) 1995-04-25
HUT70520A (en) 1995-10-30
NO180632B (no) 1997-02-10
ATE206398T1 (de) 2001-10-15
NO941884D0 (no) 1994-05-19
NO941884L (no) 1994-05-19
FI942310A (fi) 1994-07-15
AU3129193A (en) 1993-06-15
PT613465E (pt) 2002-03-28
RU2116297C1 (ru) 1998-07-27
FI942310A0 (fi) 1994-05-18
KR100234600B1 (ko) 1999-12-15
FI107383B (fi) 2001-07-31
EP0545095A1 (en) 1993-06-09
AU664872B2 (en) 1995-12-07
CZ284181B6 (cs) 1998-09-16
JPH07501075A (ja) 1995-02-02
JP3193718B2 (ja) 2001-07-30
SK56994A3 (en) 1995-02-08
CZ116194A3 (en) 1994-11-16
RU94028888A (ru) 1997-02-20
NO180632C (no) 1997-05-21
EP0613465A1 (en) 1994-09-07
HU9401468D0 (en) 1994-08-29
CA2122911A1 (en) 1993-05-27
WO1993010092A1 (en) 1993-05-27
SG46641A1 (en) 1998-02-20
DE69232099D1 (de) 2001-11-08
US5314896A (en) 1994-05-24
HU218935B (hu) 2001-01-29
FI980471A (fi) 1998-03-02
FI106259B (fi) 2000-12-29
EP0613465B1 (en) 2001-10-04
ES2165360T3 (es) 2002-03-16
DK0613465T3 (da) 2002-02-04
FI980471A0 (fi) 1998-03-02

Similar Documents

Publication Publication Date Title
SK280812B6 (sk) 1,3-substituované cykloalkány a 1,3-substituované cykloalkény, spôsoby ich prípravy a farmaceutické prípravky na ich báze
DE60024986T2 (de) Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung
DE68920482T2 (de) 1-Indolylalkyl-4-(substituierte Pyridinyl)-Piperazine.
US6498168B2 (en) Muscarinic antagonists
CZ151297A3 (cs) Dihydropyrimidinové sloučeniny a farmaceutické prostředky na jejich bázi
JPS59219260A (ja) 新規なナフタレン−およびアザナフタレン−カルボキサミド誘導体、それを含有する製薬学的組成物、並びにそれらの製造法
BG60538B2 (bg) Нови //бис(арил)метилен/-1-пиперидинил/-алкил-пиримидинони
US5001134A (en) Piperidines, processes of preparation and medications containing them
US5286735A (en) Derivatives of 4-aminomethylpiperidine, their preparation and their use as therapeutics
EP0784055B1 (en) Pyrimidinylpyrazole derivative
DK168291B1 (da) N-substituerede diphenylpiperidiner, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende forbindelserne samt anvendelse af forbindelserne samt anvendelse af forbindelserne til fremstilling af et lægemiddel til anvendelse til forebyggelse eller behandling af fedme
EP0964863B1 (de) Oxazolidinone als 5-ht2a-antagonisten
KR0166359B1 (ko) 중추 신경계 약제로서 유용한 치환 시클로헥센
US4845113A (en) 2-substituted -1,4-dihydropyridines and pharmaceutical compositions containing them
NZ202974A (en) Benzodioxine derivatives and pharmaceutical compositions
US5089497A (en) Substituted piperazines as central nervous system agents
US5045550A (en) Substituted tetrahydropyridines as central nervous system agents
US5118691A (en) Substituted tetrahydropyridines as central nervous system agents
US4448777A (en) 1-Phenylindazole-3-one compounds, process and intermediates for their preparation, and pharmaceutical compositions containing same
DK158944B (da) Analogifremgangsmaade til fremstilling af substituerede methylimidazolforbindelser
US5658910A (en) Nicotinic acid esters
KR100917041B1 (ko) 5-ｈｔ7 수용체에 길항작용을 갖는 신규한 화합물
KR20010072407A (ko) Ｎ-치환 아자비시클로헵탄 유도체, 그의 제조 및 용도