SK279521B6 - Použitie rapamicínu - Google Patents

Použitie rapamicínu Download PDF

Info

Publication number
SK279521B6
SK279521B6 SK2785-92A SK278592A SK279521B6 SK 279521 B6 SK279521 B6 SK 279521B6 SK 278592 A SK278592 A SK 278592A SK 279521 B6 SK279521 B6 SK 279521B6
Authority
SK
Slovakia
Prior art keywords
skin
rapamicin
dermatitis
erythema
diseases
Prior art date
Application number
SK2785-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK278592A3 (en
Inventor
Craig E. Caufield
John H. Musser
Surendra N. Seghal
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of SK278592A3 publication Critical patent/SK278592A3/sk
Publication of SK279521B6 publication Critical patent/SK279521B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SK2785-92A 1991-09-17 1992-09-09 Použitie rapamicínu SK279521B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76112091A 1991-09-17 1991-09-17

Publications (2)

Publication Number Publication Date
SK278592A3 SK278592A3 (en) 1995-03-08
SK279521B6 true SK279521B6 (sk) 1998-12-02

Family

ID=25061205

Family Applications (1)

Application Number Title Priority Date Filing Date
SK2785-92A SK279521B6 (sk) 1991-09-17 1992-09-09 Použitie rapamicínu

Country Status (23)

Country Link
US (1) US5286730A (de)
EP (1) EP0533433B1 (de)
JP (1) JP2810599B2 (de)
KR (1) KR100299394B1 (de)
AT (1) ATE151289T1 (de)
AU (1) AU659868B2 (de)
CA (1) CA2078379C (de)
CZ (1) CZ281900B6 (de)
DE (1) DE69218864T2 (de)
DK (1) DK0533433T3 (de)
ES (1) ES2100297T3 (de)
GR (1) GR3023680T3 (de)
HK (1) HK108697A (de)
HU (1) HU211112B (de)
IL (3) IL117640A (de)
MX (1) MX9205202A (de)
NZ (2) NZ328124A (de)
PH (1) PH30270A (de)
SG (1) SG43126A1 (de)
SK (1) SK279521B6 (de)
TW (1) TW212759B (de)
UA (1) UA27742C2 (de)
ZA (1) ZA927010B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286731A (en) * 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
JP2741285B2 (ja) * 1992-05-22 1998-04-15 千寿製薬株式会社 緑内障治療剤
US5480988A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5434260A (en) * 1992-10-13 1995-07-18 American Home Products Corporation Carbamates of rapamycin
US5489680A (en) * 1992-10-13 1996-02-06 American Home Products Corporation Carbamates of rapamycin
US5480989A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
DE4329503A1 (de) * 1993-09-01 1995-03-02 Galenik Labor Freiburg Gmbh Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
WO1995014023A1 (en) * 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5389639A (en) * 1993-12-29 1995-02-14 American Home Products Company Amino alkanoic esters of rapamycin
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5463048A (en) * 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
US5849730A (en) * 1994-08-31 1998-12-15 Pfizer Inc. Process for preparing demethylrapamycins
US5561138A (en) * 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5496832A (en) * 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
BE1009856A5 (fr) 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US5912224A (en) * 1996-02-22 1999-06-15 The General Hospital Corporation Methods and compositions for enhancing cellular response to TGF-β ligands
CA2261666C (en) * 1996-07-30 2010-09-14 Novartis Ag Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin
EP0954310A1 (de) * 1996-10-31 1999-11-10 American Home Products Corporation Synergistische zusammensetzung enthaltend rapamycin und calcitriol
DE19844397A1 (de) * 1998-09-28 2000-03-30 Hilti Ag Abrasive Schneidkörper enthaltend Diamantpartikel und Verfahren zur Herstellung der Schneidkörper
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
JP2004509898A (ja) 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
US6399625B1 (en) 2000-09-27 2002-06-04 Wyeth 1-oxorapamycins
US6399626B1 (en) 2000-10-02 2002-06-04 Wyeth Hydroxyesters of 7-desmethylrapamycin
US6440991B1 (en) 2000-10-02 2002-08-27 Wyeth Ethers of 7-desmethlrapamycin
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
TWI286074B (en) 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
KR20020050135A (ko) * 2000-12-20 2002-06-26 조명재 피부 주름 예방 및 완화를 목적으로 하는 피부 외용 조성물
TWI296196B (en) * 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
TWI233359B (en) * 2001-04-06 2005-06-01 Wyeth Corp Pharmaceutical composition for treating neoplasm
US20020198137A1 (en) * 2001-06-01 2002-12-26 Wyeth Antineoplastic combinations
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
EP1419153A1 (de) 2001-08-22 2004-05-19 Wyeth Rapamycindialdehyde
EP1419154B1 (de) 2001-08-22 2005-10-05 Wyeth Rapanycin29-enole
US6641611B2 (en) * 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US20030220297A1 (en) 2002-02-01 2003-11-27 Berstein David L. Phosphorus-containing compounds and uses thereof
BR0313024A (pt) 2002-07-30 2005-07-12 Wyeth Corp Formulações parenterais contendo um hidroxiéster de rapamicina
EP1389480A1 (de) * 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutische Anwendung von Guanylhydrazone zur Hemmung von CD83 abhängige Verfahren und Reifung der dendritischen Zellen
CN100415233C (zh) * 2002-09-17 2008-09-03 惠氏公司 口服制剂
AR042938A1 (es) * 2003-02-06 2005-07-06 Wyeth Corp Uso del cci-779 en el tratamiento de la fibrosis hepatica
UA83484C2 (uk) * 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
US20040258662A1 (en) * 2003-04-22 2004-12-23 Wyeth Antineoplastic agents
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
JP2007511521A (ja) * 2003-11-13 2007-05-10 コンビナトアールエックス インコーポレーティッド 炎症性障害を治療する方法および試薬
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
AU2006315512B2 (en) 2005-11-14 2012-11-01 Ariad Pharmaceuticals, Inc. Administration of an mTOR inhibitor to treat patients with cancer
WO2008022256A2 (en) * 2006-08-16 2008-02-21 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
EP2431036B1 (de) 2006-09-13 2017-04-12 Elixir Medical Corporation Makrocyclische Lactonverbindungen und Verfahren zu deren Verwendung
MX2009004962A (es) * 2006-11-07 2009-05-21 Alcon Res Ltd Metodo para tratar asma, rinitis alergia y trastornos de la piel.
WO2008063563A2 (en) * 2006-11-16 2008-05-29 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mtor inhibitors
CN102231969A (zh) * 2008-10-03 2011-11-02 万能医药公司 大环内酯化合物及其使用方法
CN104997774A (zh) 2009-04-10 2015-10-28 齐海燕 新的抗衰老试剂及其鉴别方法
AU2014209141B2 (en) 2013-01-24 2018-05-10 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mTOR inhibitors
WO2015056160A1 (en) * 2013-10-14 2015-04-23 Izun Pharmaceuticals Ltd. Methods for treatment of m-tor inhibitor-associated stomatitis
HUP1400075A2 (hu) 2014-02-14 2015-08-28 Druggability Technologies Ip Holdco Jersey Ltd Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
US20160184279A1 (en) * 2014-12-10 2016-06-30 Transderm, Inc. METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY
JP2018528236A (ja) 2015-09-24 2018-09-27 ドレクセル ユニバーシティ 真皮障害を治療または予防するための新規組成物および方法
AU2018205253B2 (en) 2017-01-06 2022-01-13 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
US10456383B2 (en) * 2017-06-01 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Targeted approach in the management of Epidermolysis bullosa
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
JP2022511270A (ja) * 2018-08-30 2022-01-31 ケミストリーアールエックス． シロリムス含有組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4023264A (en) * 1976-06-21 1977-05-17 Littelfuse, Inc. Method of making miniature plug-in fuses of different fuse ratings
DK175235B1 (da) * 1987-11-09 2004-07-19 Novartis Ag Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin
DE69129459T2 (de) * 1990-08-10 1998-10-15 Anormed Inc Immunosuppressive zusammensetzungen
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5080899A (en) * 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) * 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus

Also Published As

Publication number Publication date
HU211112B (en) 1995-10-30
HK108697A (en) 1997-08-22
HUT64846A (en) 1994-03-28
AU659868B2 (en) 1995-06-01
JPH05194529A (ja) 1993-08-03
IL117640A (en) 1999-08-17
NZ244340A (en) 1999-06-29
DK0533433T3 (da) 1997-05-12
GR3023680T3 (en) 1997-09-30
EP0533433A1 (de) 1993-03-24
SK278592A3 (en) 1995-03-08
DE69218864D1 (de) 1997-05-15
NZ328124A (en) 2000-01-28
IL103189A0 (en) 1993-02-21
PH30270A (en) 1997-02-20
CA2078379A1 (en) 1993-03-18
CZ278592A3 (en) 1993-04-14
US5286730A (en) 1994-02-15
ES2100297T3 (es) 1997-06-16
AU2450792A (en) 1993-03-18
CZ281900B6 (cs) 1997-03-12
IL117640A0 (en) 1996-07-23
SG43126A1 (en) 1997-10-17
MX9205202A (es) 1993-03-01
HU9202955D0 (en) 1992-12-28
KR100299394B1 (ko) 2001-10-22
JP2810599B2 (ja) 1998-10-15
DE69218864T2 (de) 1997-07-17
EP0533433B1 (de) 1997-04-09
ZA927010B (en) 1994-03-14
UA27742C2 (uk) 2000-10-16
IL103189A (en) 1996-08-04
TW212759B (de) 1993-09-11
CA2078379C (en) 2003-07-29
ATE151289T1 (de) 1997-04-15

Similar Documents

Publication Publication Date Title
SK279521B6 (sk) Použitie rapamicínu
US5286731A (en) Method of treating immunoinflammatory bowel disease
CA2074641C (en) Method of treating ocular inflammation
CA2086642C (en) Method of treating hyperproliferative vascular disease
EP0746314A1 (de) Verfahren zur behandlung von hyperproliferativer gefässerkrankung
EP1689390B1 (de) Verfahren und reagenzien zur behandlung von entzündlichen erkrankungen
CA2612244A1 (en) Methods and reagents for the treatment of inflammatory disorders
De Tran et al. Tacrolimus in dermatology
EP0561772A1 (de) Neue Verwendung von Fusidinsäure und Derivaten davon als Heilmittel
AU757489B2 (en) Method for inhibiting cytokine production by cells
TR201803213A2 (tr) Psori̇asi̇s tedavi̇si̇ i̇çi̇n pi̇mekroli̇mus, klobetazol ve kalsi̇potri̇ol i̇çeren topi̇kal farmasöti̇k formülasyonlar