SK279353B6 - Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet - Google Patents

Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet Download PDF

Info

Publication number
SK279353B6
SK279353B6 SK1125-93A SK112593A SK279353B6 SK 279353 B6 SK279353 B6 SK 279353B6 SK 112593 A SK112593 A SK 112593A SK 279353 B6 SK279353 B6 SK 279353B6
Authority
SK
Slovakia
Prior art keywords
methyl
ethyl
chlorophenyl
dihydro
amplodipine
Prior art date
Application number
SK1125-93A
Other languages
English (en)
Slovak (sk)
Other versions
SK112593A3 (en
Inventor
Borut Furlan
Anton Čopar
Alenka Jeriha
Original Assignee
Lek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek filed Critical Lek
Publication of SK112593A3 publication Critical patent/SK112593A3/sk
Publication of SK279353B6 publication Critical patent/SK279353B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
SK1125-93A 1992-11-26 1993-10-15 Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet SK279353B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9200344A SI9200344B (sl) 1992-11-26 1992-11-26 Postopek za pripravo amlodipin benzensulfonata

Publications (2)

Publication Number Publication Date
SK112593A3 SK112593A3 (en) 1994-11-09
SK279353B6 true SK279353B6 (sk) 1998-10-07

Family

ID=20431051

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1125-93A SK279353B6 (sk) 1992-11-26 1993-10-15 Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet

Country Status (9)

Country Link
EP (1) EP0599220B1 (fr)
CZ (1) CZ283041B6 (fr)
DE (1) DE69304020T2 (fr)
FI (1) FI103042B (fr)
HR (1) HRP931429B1 (fr)
PL (2) PL173645B1 (fr)
RU (1) RU2105759C1 (fr)
SI (1) SI9200344B (fr)
SK (1) SK279353B6 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
UA72768C2 (en) 1999-07-05 2005-04-15 Richter Gedeon Vegyeszet A method for obtaining amilodipine benzenesulphonate
ATE454890T1 (de) * 2001-07-06 2010-01-15 Lek Pharmaceuticals Verfahren zur herstellung hochreines amlodipinbenzolsulfonat
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
US6828339B2 (en) * 2001-11-21 2004-12-07 Synthon Bv Amlodipine salt forms and processes for preparing them
SI21233A (sl) * 2002-05-31 2003-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba
US6784297B2 (en) 2002-09-04 2004-08-31 Kopran Limited Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
EP1407773A1 (fr) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research Procede pour la preparation des sels de s(-)amlodipine
WO2004058711A1 (fr) * 2002-12-30 2004-07-15 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation de derive de dihydropyridine et sels de preparation de celui-ci
AU2004226547B2 (en) 2003-03-28 2008-10-23 Nissan Chemical Industries,Ltd. T-Type calcium channel blockers
WO2007131759A1 (fr) * 2006-05-15 2007-11-22 Lek Pharmaceuticals D.D. Procédé de préparation de benzènesulfonate d'amlodipine
LT2824100T (lt) 2008-07-08 2018-05-10 Incyte Holdings Corporation 1,2,5-oksadiazolai, kaip indolamino 2,3-dioksigenazės inhibitoriai
US8846012B2 (en) 2008-12-22 2014-09-30 Pola Chemical Industries Inc. Melanin production inhibitor
CN102516159B (zh) * 2011-12-15 2013-10-09 扬子江药业集团江苏海慈生物药业有限公司 一种苯磺酸左旋氨氯地平的生产方法
WO2014066834A1 (fr) 2012-10-26 2014-05-01 The University Of Chicago Combinaison synergique d'inhibiteurs immunologiques pour le traitement du cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
EP0352863A3 (fr) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. Dérivés d'acides 1,4-dihydropyridine dicarboxyliques

Also Published As

Publication number Publication date
CZ216593A3 (en) 1994-06-15
DE69304020T2 (de) 1997-03-06
RU2105759C1 (ru) 1998-02-27
EP0599220A1 (fr) 1994-06-01
SK112593A3 (en) 1994-11-09
SI9200344B (sl) 1998-06-30
PL173645B1 (pl) 1998-04-30
SI9200344A (en) 1994-06-30
HRP931429A2 (en) 1995-12-31
FI934882A0 (fi) 1993-11-04
EP0599220B1 (fr) 1996-08-14
FI934882A (fi) 1994-05-27
CZ283041B6 (cs) 1997-12-17
PL301080A1 (en) 1994-05-30
DE69304020D1 (de) 1996-09-19
HRP931429B1 (en) 1997-10-31
FI103042B1 (fi) 1999-04-15
FI103042B (fi) 1999-04-15
PL174647B1 (pl) 1998-08-31

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20121015