SK279298B6 - Deriváty camptothecinu, spôsob ich výroby, farmace - Google Patents
Deriváty camptothecinu, spôsob ich výroby, farmace Download PDFInfo
- Publication number
- SK279298B6 SK279298B6 SK3237-92A SK323792A SK279298B6 SK 279298 B6 SK279298 B6 SK 279298B6 SK 323792 A SK323792 A SK 323792A SK 279298 B6 SK279298 B6 SK 279298B6
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- camptothecin
- ethylenedioxy
- formula
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78427591A | 1991-10-29 | 1991-10-29 | |
| US82672992A | 1992-01-28 | 1992-01-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK279298B6 true SK279298B6 (sk) | 1998-09-09 |
| SK323792A3 SK323792A3 (en) | 1998-09-09 |
Family
ID=27120258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK3237-92A SK323792A3 (en) | 1991-10-29 | 1992-10-27 | Camptothecin derivatives, method of producing the same, pharmaceutical compositions containing same, their use and intermediate products |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0540099B1 (ru) |
| JP (2) | JP3020760B2 (ru) |
| KR (1) | KR100246154B1 (ru) |
| CN (1) | CN1072683A (ru) |
| AP (1) | AP306A (ru) |
| AT (1) | ATE136898T1 (ru) |
| AU (1) | AU657007B2 (ru) |
| CA (1) | CA2081580A1 (ru) |
| CZ (1) | CZ284023B6 (ru) |
| DE (1) | DE69209969T2 (ru) |
| DK (1) | DK0540099T3 (ru) |
| ES (1) | ES2086643T3 (ru) |
| FI (3) | FI104373B (ru) |
| GR (1) | GR3020120T3 (ru) |
| HU (2) | HU217970B (ru) |
| IL (1) | IL103571A (ru) |
| IS (1) | IS1708B (ru) |
| MX (1) | MX9206211A (ru) |
| MY (1) | MY108261A (ru) |
| NO (1) | NO302073B1 (ru) |
| NZ (1) | NZ244914A (ru) |
| OA (1) | OA09767A (ru) |
| RU (1) | RU2119921C1 (ru) |
| SK (1) | SK323792A3 (ru) |
| TW (1) | TW221994B (ru) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
| ES2186812T3 (es) * | 1993-01-15 | 2003-05-16 | Stehlin Foundation For Cancer | Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado. |
| US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
| IS4152A (is) * | 1993-04-29 | 1994-10-30 | Glaxo Inc. | Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra |
| JPH08509742A (ja) * | 1993-05-03 | 1996-10-15 | スミスクライン・ビーチャム・コーポレイション | 置換メチレンジオキシ［３’，４’：６，７］インドリジノ［１，２−ｂ］キノリノン |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
| IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| KR960029336A (ko) | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
| US5496952A (en) * | 1995-02-07 | 1996-03-05 | North Carolina State University | Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
| US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| ATE275132T1 (de) * | 1995-06-27 | 2004-09-15 | Takeda Chemical Industries Ltd | 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| SG116433A1 (en) * | 1996-10-30 | 2005-11-28 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof. |
| US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
| US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| EP1278518B1 (en) | 2000-02-28 | 2006-11-08 | Pfizer Enterprises SARL | Synergistic combination for the treatment of colorectal cancer |
| US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| YU29803A (sh) | 2000-10-27 | 2006-05-25 | Aventis Pharma S.A. | Kombinacija kamptotekina i derivata stilbena za lečenje raka |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| WO2006069344A2 (en) | 2004-12-22 | 2006-06-29 | Rutgers, The State University Of New Jersey | Controlled release hydrogels |
| WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| EP1998809B1 (en) | 2006-03-30 | 2014-06-25 | Drais Pharmaceuticals, Inc. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
| CN101407524B (zh) * | 2007-10-09 | 2012-07-18 | 江苏先声药物研究有限公司 | 噁嗪骈喜树碱衍生物及其制备方法和用途 |
| CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
| ES2373172B1 (es) * | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
| US8980909B2 (en) | 2011-01-12 | 2015-03-17 | Crystal Biopharmaceutical Llc | HDAC inhibiting derivatives of camptothecin |
| IL277748B1 (en) * | 2018-04-06 | 2024-03-01 | Seagen Inc | Camptothecin peptide conjugates |
| CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
| CN117769555A (zh) * | 2021-08-19 | 2024-03-26 | 先声再明医药有限公司 | 喜树碱衍生物、其药物组合物及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1992
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-23 EP EP92203263A patent/EP0540099B1/en not_active Expired - Lifetime
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-27 SK SK3237-92A patent/SK323792A3/sk unknown
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active IP Right Cessation
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
- 1992-10-28 CA CA002081580A patent/CA2081580A1/en not_active Abandoned
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
-
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
-
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
-
1998
- 1998-10-08 FI FI982185A patent/FI982185A/fi unknown
-
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
-
2002
- 2002-06-07 FI FI20021090A patent/FI20021090A/fi not_active Application Discontinuation
Also Published As
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