SK2722002A3 - Use of bis-sulfonamides for producing medicaments used for preventing or treating hyperlipidaemia - Google Patents
Use of bis-sulfonamides for producing medicaments used for preventing or treating hyperlipidaemia Download PDFInfo
- Publication number
- SK2722002A3 SK2722002A3 SK272-2002A SK2722002A SK2722002A3 SK 2722002 A3 SK2722002 A3 SK 2722002A3 SK 2722002 A SK2722002 A SK 2722002A SK 2722002 A3 SK2722002 A3 SK 2722002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- phenyl
- group
- cycloalkyl
- pyridyl
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims abstract description 16
- 229940124530 sulfonamide Drugs 0.000 title abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 53
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 206010003210 Arteriosclerosis Diseases 0.000 claims abstract description 5
- 208000011775 arteriosclerosis disease Diseases 0.000 claims abstract description 5
- -1 4-thiazo Chemical group 0.000 claims description 124
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 120
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 48
- 239000000460 chlorine Chemical group 0.000 claims description 42
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 24
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 22
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 21
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 21
- 229910052731 fluorine Inorganic materials 0.000 claims description 21
- 229910052801 chlorine Inorganic materials 0.000 claims description 20
- 238000011282 treatment Methods 0.000 claims description 20
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 19
- 125000001153 fluoro group Chemical group F* 0.000 claims description 18
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 17
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 17
- 229910052794 bromium Inorganic materials 0.000 claims description 17
- 239000011737 fluorine Substances 0.000 claims description 17
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 16
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 16
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 16
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 14
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 13
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 12
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 12
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 12
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 11
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 10
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 claims description 10
- 125000005936 piperidyl group Chemical group 0.000 claims description 10
- 230000002265 prevention Effects 0.000 claims description 10
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 10
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 9
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims description 9
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 9
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 9
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 claims description 8
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 claims description 8
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims description 8
- 125000002757 morpholinyl group Chemical group 0.000 claims description 7
- 125000004193 piperazinyl group Chemical group 0.000 claims description 7
- 125000003386 piperidinyl group Chemical group 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 7
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 6
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 5
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 5
- 125000004539 5-benzimidazolyl group Chemical group N1=CNC2=C1C=CC(=C2)* 0.000 claims description 5
- 239000003524 antilipemic agent Substances 0.000 claims description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims description 5
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 229910052740 iodine Inorganic materials 0.000 claims description 4
- 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 claims description 3
- 125000001414 1,2,4-triazol-5-yl group Chemical group [H]N1N=C([H])N=C1[*] 0.000 claims description 3
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims description 3
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 3
- 239000004305 biphenyl Substances 0.000 claims description 3
- 235000010290 biphenyl Nutrition 0.000 claims description 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 3
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims description 3
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000004526 pyridazin-2-yl group Chemical group N1N(C=CC=C1)* 0.000 claims description 2
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims description 2
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 claims 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 125000005322 morpholin-1-yl group Chemical group 0.000 claims 1
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 23
- 239000013543 active substance Substances 0.000 description 13
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19941559A DE19941559A1 (de) | 1999-09-01 | 1999-09-01 | Verwendung von Bissulfonamiden zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Hyperlipidömie |
| PCT/EP2000/008026 WO2001016096A2 (de) | 1999-09-01 | 2000-08-17 | Verwendung von bissulfonamiden zur herstellung von medikamenten zur prophylaxe oder behandlung von hyperlipidämie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK2722002A3 true SK2722002A3 (en) | 2002-07-02 |
Family
ID=7920369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK272-2002A SK2722002A3 (en) | 1999-09-01 | 2000-08-17 | Use of bis-sulfonamides for producing medicaments used for preventing or treating hyperlipidaemia |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6632838B1 (zh) |
| EP (1) | EP1237859B1 (zh) |
| JP (1) | JP4982021B2 (zh) |
| KR (1) | KR20020023429A (zh) |
| CN (1) | CN1384742A (zh) |
| AT (1) | ATE380789T1 (zh) |
| AU (1) | AU775336B2 (zh) |
| BR (1) | BR0013723A (zh) |
| CA (1) | CA2383783A1 (zh) |
| CZ (1) | CZ2002708A3 (zh) |
| DE (2) | DE19941559A1 (zh) |
| EE (1) | EE200200088A (zh) |
| HR (1) | HRP20020178A2 (zh) |
| HU (1) | HUP0204282A2 (zh) |
| IL (1) | IL148147A0 (zh) |
| MX (1) | MXPA02001740A (zh) |
| NO (1) | NO20020812L (zh) |
| NZ (1) | NZ517485A (zh) |
| PL (1) | PL353205A1 (zh) |
| RU (1) | RU2002107996A (zh) |
| SK (1) | SK2722002A3 (zh) |
| WO (1) | WO2001016096A2 (zh) |
| ZA (1) | ZA200201592B (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS88803A (en) * | 2001-05-11 | 2007-02-05 | Biovitrum Ab., | Novel-arylsulfonamide compounds for the treatment of obesity type ii diabetes and cns-disorders |
| CN1329382C (zh) * | 2001-05-11 | 2007-08-01 | 比奥维特罗姆股份公司 | 治疗肥胖、ⅱ型糖尿病和cns－疾病的芳基磺酰胺化合物 |
| US7718650B2 (en) * | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
| US20070185248A1 (en) * | 2004-06-25 | 2007-08-09 | Polyone Corporation | Intumescent polylefin nanocomposites and their use |
| JP4925629B2 (ja) * | 2005-09-02 | 2012-05-09 | 住友化学株式会社 | スルホンアミド化合物 |
| WO2008129288A2 (en) * | 2007-04-19 | 2008-10-30 | Boehringer Ingelheim International Gmbh | Disulfonamides useful in the treatment of inflammation |
| TW200930368A (en) * | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| TW200930369A (en) * | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| US20090163586A1 (en) * | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| WO2010132016A1 (en) * | 2009-05-14 | 2010-11-18 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives for treatment of pain and inflammation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1353357A (en) * | 1970-09-14 | 1974-05-15 | Pfizer | Substituted 5-sulphamylbenzoic acids |
| NL7310889A (zh) * | 1972-08-12 | 1974-02-14 | ||
| DE2459394A1 (de) * | 1974-12-16 | 1976-06-24 | Hoechst Ag | Basisch substituierte benzol-1,3- disulfonamide und verfahren zu ihrer herstellung |
| FR2517202B1 (fr) * | 1981-12-02 | 1986-07-04 | Choay Sa | Compositions pharmaceutiques presentant des proprietes normolipemiantes et contenant des composes ayant une structure du type benzenesulfonamides n-substitues |
| DE3713757A1 (de) | 1987-04-24 | 1988-11-10 | Hoechst Ag | Benzolsulfonamidderivate und verfahren zu ihrer herstellung |
| DE3905075A1 (de) * | 1989-02-18 | 1990-08-30 | Hoechst Ag | Benzolsulfonamide und verfahren zu ihrer herstellung |
-
1999
- 1999-09-01 DE DE19941559A patent/DE19941559A1/de not_active Withdrawn
-
2000
- 2000-08-17 SK SK272-2002A patent/SK2722002A3/sk unknown
- 2000-08-17 PL PL00353205A patent/PL353205A1/xx not_active Application Discontinuation
- 2000-08-17 IL IL14814700A patent/IL148147A0/xx unknown
- 2000-08-17 EE EEP200200088A patent/EE200200088A/xx unknown
- 2000-08-17 CN CN00812133A patent/CN1384742A/zh active Pending
- 2000-08-17 MX MXPA02001740A patent/MXPA02001740A/es active IP Right Grant
- 2000-08-17 CA CA002383783A patent/CA2383783A1/en not_active Abandoned
- 2000-08-17 WO PCT/EP2000/008026 patent/WO2001016096A2/de active IP Right Grant
- 2000-08-17 JP JP2001519666A patent/JP4982021B2/ja not_active Expired - Fee Related
- 2000-08-17 KR KR1020027002627A patent/KR20020023429A/ko not_active Application Discontinuation
- 2000-08-17 DE DE50014850T patent/DE50014850D1/de not_active Expired - Lifetime
- 2000-08-17 RU RU2002107996/14A patent/RU2002107996A/ru not_active Application Discontinuation
- 2000-08-17 EP EP00962330A patent/EP1237859B1/de not_active Expired - Lifetime
- 2000-08-17 AU AU74099/00A patent/AU775336B2/en not_active Ceased
- 2000-08-17 NZ NZ517485A patent/NZ517485A/en unknown
- 2000-08-17 CZ CZ2002708A patent/CZ2002708A3/cs unknown
- 2000-08-17 AT AT00962330T patent/ATE380789T1/de not_active IP Right Cessation
- 2000-08-17 HU HU0204282A patent/HUP0204282A2/hu unknown
- 2000-08-17 BR BR0013723-5A patent/BR0013723A/pt not_active IP Right Cessation
- 2000-08-31 US US09/653,253 patent/US6632838B1/en not_active Expired - Lifetime
-
2002
- 2002-02-19 NO NO20020812A patent/NO20020812L/no not_active Application Discontinuation
- 2002-02-26 ZA ZA200201592A patent/ZA200201592B/en unknown
- 2002-02-27 HR HR20020178A patent/HRP20020178A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20020812L (no) | 2002-04-30 |
| BR0013723A (pt) | 2002-05-07 |
| AU775336B2 (en) | 2004-07-29 |
| IL148147A0 (en) | 2002-09-12 |
| ZA200201592B (en) | 2003-01-29 |
| CZ2002708A3 (cs) | 2002-05-15 |
| EE200200088A (et) | 2003-04-15 |
| EP1237859B1 (de) | 2007-12-12 |
| DE19941559A1 (de) | 2001-03-15 |
| DE50014850D1 (de) | 2008-01-24 |
| US6632838B1 (en) | 2003-10-14 |
| EP1237859A2 (de) | 2002-09-11 |
| NO20020812D0 (no) | 2002-02-19 |
| MXPA02001740A (es) | 2002-08-06 |
| AU7409900A (en) | 2001-03-26 |
| CA2383783A1 (en) | 2001-03-08 |
| ATE380789T1 (de) | 2007-12-15 |
| KR20020023429A (ko) | 2002-03-28 |
| WO2001016096A3 (de) | 2002-07-04 |
| CN1384742A (zh) | 2002-12-11 |
| PL353205A1 (en) | 2003-11-03 |
| WO2001016096A2 (de) | 2001-03-08 |
| NZ517485A (en) | 2004-01-30 |
| JP4982021B2 (ja) | 2012-07-25 |
| HUP0204282A2 (hu) | 2003-06-28 |
| RU2002107996A (ru) | 2003-11-20 |
| HRP20020178A2 (en) | 2004-02-29 |
| JP2003508381A (ja) | 2003-03-04 |
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