WO2011140832A1 - 己烯酮类化合物及其医药用途 - Google Patents
己烯酮类化合物及其医药用途 Download PDFInfo
- Publication number
- WO2011140832A1 WO2011140832A1 PCT/CN2011/000848 CN2011000848W WO2011140832A1 WO 2011140832 A1 WO2011140832 A1 WO 2011140832A1 CN 2011000848 W CN2011000848 W CN 2011000848W WO 2011140832 A1 WO2011140832 A1 WO 2011140832A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- group
- substituted
- phenyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/194—Radicals derived from thio- or thiono carboxylic acids
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/696,697 US8884007B2 (en) | 2010-05-14 | 2011-05-16 | Hexenone compounds and medical use thereof |
EP11780054.0A EP2570408B1 (en) | 2010-05-14 | 2011-05-16 | Hexaketide compound and medicinal use thereof |
JP2013509428A JP5858298B2 (ja) | 2010-05-14 | 2011-05-16 | ヘキセノン化合物及びその医学的使用 |
RU2012154071/04A RU2553668C2 (ru) | 2010-05-14 | 2011-05-16 | Соединения гексенона и их применение в медицинских целях |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010172482.0A CN102241646B (zh) | 2010-05-14 | 2010-05-14 | 己烯酮类化合物及其医药用途 |
CN201010172482.0 | 2010-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011140832A1 true WO2011140832A1 (zh) | 2011-11-17 |
Family
ID=44913887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2011/000848 WO2011140832A1 (zh) | 2010-05-14 | 2011-05-16 | 己烯酮类化合物及其医药用途 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8884007B2 (zh) |
EP (1) | EP2570408B1 (zh) |
JP (1) | JP5858298B2 (zh) |
CN (1) | CN102241646B (zh) |
RU (1) | RU2553668C2 (zh) |
WO (1) | WO2011140832A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109232341B (zh) * | 2018-10-08 | 2020-01-10 | 中国人民解放军总医院 | 一种化合物或其药学上可接受的盐及其用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041679A (en) * | 1988-01-07 | 1991-08-20 | Sumitomo Chemical Company, Limited | Beta-hydroxyketone and its production |
CN1852709A (zh) * | 2003-08-06 | 2006-10-25 | 创新信号股份有限公司 | 巨噬细胞活化抑制剂 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60116642A (ja) * | 1983-11-29 | 1985-06-24 | Nippon Kayaku Co Ltd | 2−モノ−置換メチル−5,5−ジメチル−シクロ−2−ヘキセノン誘導体 |
AP1258A (en) * | 1998-02-26 | 2004-03-15 | Aventis Pharma Inc | 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines. |
CN1845741A (zh) * | 2003-07-02 | 2006-10-11 | 健泰科生物技术公司 | Trp-p8活性化合物和治病性治疗方法 |
CN100347163C (zh) * | 2005-09-05 | 2007-11-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 环己烯酮类双环(稠环)化合物及其制备方法与用途 |
-
2010
- 2010-05-14 CN CN201010172482.0A patent/CN102241646B/zh active Active
-
2011
- 2011-05-16 WO PCT/CN2011/000848 patent/WO2011140832A1/zh active Application Filing
- 2011-05-16 JP JP2013509428A patent/JP5858298B2/ja not_active Expired - Fee Related
- 2011-05-16 EP EP11780054.0A patent/EP2570408B1/en active Active
- 2011-05-16 RU RU2012154071/04A patent/RU2553668C2/ru active
- 2011-05-16 US US13/696,697 patent/US8884007B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041679A (en) * | 1988-01-07 | 1991-08-20 | Sumitomo Chemical Company, Limited | Beta-hydroxyketone and its production |
CN1852709A (zh) * | 2003-08-06 | 2006-10-25 | 创新信号股份有限公司 | 巨噬细胞活化抑制剂 |
Non-Patent Citations (4)
Title |
---|
"Design Of Prodrugs", 1985, ELSEVIER |
"Enantiomers, Racemates and Resolution", 1981, WILEY INTERSCIENCE |
KREIDER; A. MESSING; H. DOAN; S.U. KIM; R.P. LISAK; D.E. PLEASURE: "Enrichment of Schwann cell cultures from neonatal rat sciatic nerve by differential adhesion", BRAIN RES, vol. 2, 1981, pages 433 - 444, XP024254946, DOI: doi:10.1016/0006-8993(81)90375-9 |
See also references of EP2570408A4 |
Also Published As
Publication number | Publication date |
---|---|
EP2570408A4 (en) | 2013-11-13 |
CN102241646B (zh) | 2014-04-09 |
CN102241646A (zh) | 2011-11-16 |
US8884007B2 (en) | 2014-11-11 |
JP5858298B2 (ja) | 2016-02-10 |
EP2570408B1 (en) | 2018-01-10 |
RU2553668C2 (ru) | 2015-06-20 |
US20130116256A1 (en) | 2013-05-09 |
EP2570408A1 (en) | 2013-03-20 |
JP2013526490A (ja) | 2013-06-24 |
RU2012154071A (ru) | 2014-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6748652B2 (ja) | 抗酸化性炎症調節剤としてのイミダゾリル三環式エノン | |
CA3024610A1 (en) | Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer | |
WO2012043891A1 (ja) | 眼疾患処置薬 | |
JP2019534310A (ja) | 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩 | |
WO2014127722A1 (zh) | 氮杂环取代二氢青蒿素衍生物及其应用 | |
JP5752239B2 (ja) | 尿素化合物及びアポトーシスを阻害するためのその使用 | |
EP0591027A1 (fr) | Dérivés de pipéridine, leur préparation et leur application en thérapeutique | |
SK2722002A3 (en) | Use of bis-sulfonamides for producing medicaments used for preventing or treating hyperlipidaemia | |
CN115043820B (zh) | Par-1抑制剂及其类似物的制备方法和在血栓性疾病防治中的应用 | |
JP5330377B2 (ja) | 3,4−ジヒドロキナゾリン誘導体 | |
CN113387909B (zh) | 2,3-环氧丁二酰衍生物的医药用途 | |
WO2011140832A1 (zh) | 己烯酮类化合物及其医药用途 | |
CN102241673B (zh) | 丙烯酰胺类化合物及其医药用途 | |
US9439881B2 (en) | Acrylamide compounds and use thereof for inhibiting apoptosis | |
WO2012122891A1 (zh) | 含肟类的氨基衍生物、其药物组合物、其制备方法及用途 | |
CN112920133B (zh) | (e)-4-甲基-2-(4-(三氟甲基)苯乙烯基)噁唑类化合物及其制备方法与用途 | |
CN102241627B (zh) | 脲类化合物及其医药用途 | |
US9139543B2 (en) | Thiazole compounds and uses thereof | |
CN114478318A (zh) | 二腈异佛尔酮衍生物、其制备方法及应用 | |
JPWO2006082822A1 (ja) | アシクロビル耐性ヘルペスウイルスによる疾患の予防・治療剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11780054 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 2013509428 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011780054 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2012154071 Country of ref document: RU Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13696697 Country of ref document: US |