SK19495A3 - Pharmaceutical compositions - Google Patents
Pharmaceutical compositions Download PDFInfo
- Publication number
- SK19495A3 SK19495A3 SK194-95A SK19495A SK19495A3 SK 19495 A3 SK19495 A3 SK 19495A3 SK 19495 A SK19495 A SK 19495A SK 19495 A3 SK19495 A3 SK 19495A3
- Authority
- SK
- Slovakia
- Prior art keywords
- benzylidene
- piperazinedione
- compound
- methyl
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929217331A GB9217331D0 (en) | 1992-08-14 | 1992-08-14 | Pharmaceutical compounds |
PCT/GB1993/001735 WO1994004513A1 (en) | 1992-08-14 | 1993-08-16 | Pharmaceutically active diketopiperazines |
Publications (1)
Publication Number | Publication Date |
---|---|
SK19495A3 true SK19495A3 (en) | 1995-11-08 |
Family
ID=10720385
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK194-95A SK19495A3 (en) | 1992-08-14 | 1993-08-16 | Pharmaceutical compositions |
SK195-95A SK19595A3 (en) | 1992-08-14 | 1993-08-16 | Diketopiperazines, method of their preparation, use and pharmaceutical agent which containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK195-95A SK19595A3 (en) | 1992-08-14 | 1993-08-16 | Diketopiperazines, method of their preparation, use and pharmaceutical agent which containing them |
Country Status (24)
Country | Link |
---|---|
US (1) | US5700804A (hu) |
EP (2) | EP0672036A1 (hu) |
JP (2) | JPH08504175A (hu) |
KR (2) | KR950702967A (hu) |
AT (1) | ATE162186T1 (hu) |
AU (2) | AU693420B2 (hu) |
BG (2) | BG99496A (hu) |
BR (2) | BR9306905A (hu) |
CA (2) | CA2141938A1 (hu) |
CZ (2) | CZ38195A3 (hu) |
DE (1) | DE69316370T2 (hu) |
DK (1) | DK0655060T3 (hu) |
ES (1) | ES2111169T3 (hu) |
FI (2) | FI950617A (hu) |
GB (2) | GB9217331D0 (hu) |
GR (1) | GR3026272T3 (hu) |
HU (2) | HUT71592A (hu) |
IL (2) | IL106695A0 (hu) |
PL (2) | PL307437A1 (hu) |
RU (2) | RU95108759A (hu) |
SK (2) | SK19495A3 (hu) |
TW (1) | TW334427B (hu) |
WO (2) | WO1994004512A1 (hu) |
ZA (2) | ZA935968B (hu) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
DK85193D0 (da) | 1993-07-16 | 1993-07-16 | Cancerforskningsfondet Af 1989 | Suppression of inhibitors |
GB9402805D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
GB9402809D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
GB9410387D0 (en) * | 1994-05-24 | 1994-07-13 | Xenova Ltd | Pharmaceutical compounds |
GB9426090D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB9426071D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB2310854B (en) * | 1994-12-23 | 1998-09-09 | Xenova Ltd | Piperazine-2,5-dione derivatives as modulators of multi-drug resistance |
GB9426224D0 (en) * | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB2311781B (en) * | 1994-12-23 | 1998-09-16 | Xenova Ltd | Piperazine 2,5 dione derivatives as modulators of multi-drug resistance |
US5891877A (en) * | 1995-02-14 | 1999-04-06 | Xenova Limited | Pharmaceutical compounds |
AU779230C (en) * | 1999-12-03 | 2006-05-25 | Emory University | Curcumin analogues for treating cancer |
US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
US6635649B2 (en) * | 2000-05-09 | 2003-10-21 | Che-Ming Teng | Piperazinedione compounds |
CA2774959C (en) | 2000-08-04 | 2016-05-31 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
ES2294026T3 (es) | 2000-09-06 | 2008-04-01 | Ap Pharma, Inc. | Polimeros degradables de poliacetal. |
US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6815214B2 (en) * | 2000-12-29 | 2004-11-09 | Celltech R & D, Inc. | Pharmaceutical uses and synthesis of diketopiperazines |
GB2372740A (en) * | 2001-01-17 | 2002-09-04 | Xenova Ltd | Diketopiperazines |
CA2478522A1 (en) * | 2002-03-08 | 2003-09-18 | Emory University | Novel curcuminoid-factor viia constructs as suppressors of tumor growth and angiogenesis |
US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
PT1529044E (pt) | 2002-08-02 | 2008-01-14 | Nereus Pharmaceuticals Inc | Desidrofenila-histinas e os seus análogos e a síntese de desidrofenila-histinas e os seus análogos |
US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
DE10238144A1 (de) * | 2002-08-15 | 2004-02-26 | Basf Ag | Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen |
WO2004030522A2 (en) | 2002-10-02 | 2004-04-15 | Dmi Biosciences, Inc. | Diagnosis and monitoring of diseases |
CA2523467C (en) * | 2003-05-15 | 2021-10-26 | Dmi Biosciences, Inc. | Treatment of t-cell mediated diseases |
GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
US7732605B2 (en) | 2005-03-29 | 2010-06-08 | Nereus Pharmaceuticals, Inc. | Synthesis of diketopiperazines |
US20070270464A1 (en) * | 2006-02-24 | 2007-11-22 | Emory University | Prodrugs of curcumin analogs |
US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
WO2012033792A2 (en) | 2010-09-07 | 2012-03-15 | Dmi Acquisition Corp. | Treatment of diseases |
CA2826973C (en) * | 2011-02-10 | 2020-03-24 | Mannkind, Corp | Formation of n-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine |
MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
AU2012323305B2 (en) | 2011-10-10 | 2017-07-27 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
AU2012328605B9 (en) | 2011-10-28 | 2017-08-03 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
US9808454B2 (en) | 2013-03-15 | 2017-11-07 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
CN103396372B (zh) * | 2013-08-09 | 2015-05-20 | 中国科学院南海海洋研究所 | 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用 |
CN105272968B (zh) * | 2014-06-10 | 2018-03-13 | 首都医科大学 | (3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用 |
US9956217B2 (en) | 2014-08-18 | 2018-05-01 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
CN104610170B (zh) * | 2015-01-14 | 2017-02-01 | 中国科学院南海海洋研究所 | 2,5‑二酮哌嗪衍生物及其制备方法和应用 |
KR102623404B1 (ko) | 2015-03-06 | 2024-01-11 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 뇌 종양 치료 방법 |
EP3265090A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating cancer associated with a ras mutation |
WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
EP3334726B1 (en) | 2015-07-13 | 2022-03-16 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
MY192703A (en) | 2016-02-08 | 2022-09-02 | Beyondspring Pharmaceuticals Inc | Compositions containing tucaresol or its analogs |
MX2018015100A (es) | 2016-06-06 | 2019-09-04 | Beyondspring Pharmaceuticals Inc | Composicion y metodo para reducir la neutropenia. |
JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
WO2018144764A1 (en) | 2017-02-01 | 2018-08-09 | Beyondspring Pharmaceuticals, Inc. | Method of reducing neutropenia |
CN110054619A (zh) * | 2018-01-18 | 2019-07-26 | 西北农林科技大学 | 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂 |
KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
US11129878B1 (en) | 2020-03-24 | 2021-09-28 | Ampio Pharmaceuticals, Inc. | Methods for treating diseases associated with respiratory viruses |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE621862C (de) * | 1932-07-01 | 1935-11-14 | Guenther Schiemann Dr | Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde |
BE584914A (hu) * | 1958-11-24 | |||
JPS5747357A (en) * | 1980-09-04 | 1982-03-18 | Ricoh Co Ltd | Novel disazo compound and its preparation |
GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
-
1992
- 1992-08-14 GB GB929217331A patent/GB9217331D0/en active Pending
-
1993
- 1993-08-15 IL IL106695A patent/IL106695A0/xx unknown
- 1993-08-15 IL IL106696A patent/IL106696A0/xx unknown
- 1993-08-16 DK DK93918032.9T patent/DK0655060T3/da active
- 1993-08-16 CA CA002141938A patent/CA2141938A1/en not_active Abandoned
- 1993-08-16 GB GB9502859A patent/GB2284420B/en not_active Expired - Fee Related
- 1993-08-16 EP EP93918033A patent/EP0672036A1/en not_active Ceased
- 1993-08-16 EP EP93918032A patent/EP0655060B1/en not_active Expired - Lifetime
- 1993-08-16 HU HU9500436A patent/HUT71592A/hu unknown
- 1993-08-16 PL PL93307437A patent/PL307437A1/xx unknown
- 1993-08-16 CZ CZ95381A patent/CZ38195A3/cs unknown
- 1993-08-16 BR BR9306905A patent/BR9306905A/pt not_active Application Discontinuation
- 1993-08-16 US US08/381,932 patent/US5700804A/en not_active Expired - Fee Related
- 1993-08-16 CA CA002141939A patent/CA2141939A1/en not_active Abandoned
- 1993-08-16 RU RU95108759/04A patent/RU95108759A/ru unknown
- 1993-08-16 SK SK194-95A patent/SK19495A3/sk unknown
- 1993-08-16 AU AU47264/93A patent/AU693420B2/en not_active Ceased
- 1993-08-16 KR KR1019950700555A patent/KR950702967A/ko not_active Application Discontinuation
- 1993-08-16 JP JP6506028A patent/JPH08504175A/ja active Pending
- 1993-08-16 AT AT93918032T patent/ATE162186T1/de active
- 1993-08-16 DE DE69316370T patent/DE69316370T2/de not_active Expired - Fee Related
- 1993-08-16 PL PL93307438A patent/PL307438A1/xx unknown
- 1993-08-16 BR BR9306904A patent/BR9306904A/pt not_active Application Discontinuation
- 1993-08-16 WO PCT/GB1993/001734 patent/WO1994004512A1/en active IP Right Grant
- 1993-08-16 AU AU47265/93A patent/AU678172B2/en not_active Ceased
- 1993-08-16 JP JP6506029A patent/JPH08504176A/ja active Pending
- 1993-08-16 RU RU95108387/04A patent/RU95108387A/ru unknown
- 1993-08-16 KR KR1019950700556A patent/KR950702968A/ko not_active Application Discontinuation
- 1993-08-16 WO PCT/GB1993/001735 patent/WO1994004513A1/en not_active Application Discontinuation
- 1993-08-16 SK SK195-95A patent/SK19595A3/sk unknown
- 1993-08-16 HU HU9500437A patent/HUT71593A/hu unknown
- 1993-08-16 ZA ZA935968A patent/ZA935968B/xx unknown
- 1993-08-16 CZ CZ95383A patent/CZ38395A3/cs unknown
- 1993-08-16 ZA ZA935969A patent/ZA935969B/xx unknown
- 1993-08-16 ES ES93918032T patent/ES2111169T3/es not_active Expired - Lifetime
- 1993-10-29 TW TW082109040A patent/TW334427B/zh active
-
1995
- 1995-02-13 FI FI950617A patent/FI950617A/fi not_active Application Discontinuation
- 1995-02-13 FI FI950616A patent/FI950616A/fi not_active Application Discontinuation
- 1995-03-13 BG BG99496A patent/BG99496A/xx unknown
- 1995-03-13 BG BG99495A patent/BG99495A/xx unknown
-
1998
- 1998-03-03 GR GR980400450T patent/GR3026272T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK19495A3 (en) | Pharmaceutical compositions | |
JP6228130B2 (ja) | 治療活性化合物およびそれらの使用方法 | |
RU2728827C2 (ru) | Кристаллическая форма ингибитора тирозинкиназы брутона и способ её получения | |
US5852018A (en) | Pharmaceutical piperazine compounds | |
EP0170213B1 (en) | Glutarimide antianxiety and antihypertensive agents | |
EP2964223A1 (en) | Compounds inhibiting leucine-rich repeat kinase enzyme activity | |
JP2018519249A (ja) | イソオキサゾリル置換ベンズイミダゾール類 | |
KR101569261B1 (ko) | 암을 치료하기 위한 hdac 억제제로서 4-아미노-n-하이드록시-벤즈아미드 | |
EA022341B1 (ru) | Производные тетрагидрохинолина, полезные в качестве ингибиторов бромодомена | |
WO2003041641A2 (en) | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity | |
TW200815387A (en) | Chromen-2-one derivatives | |
JP2593273B2 (ja) | 置換ジアミノフタルイミドおよび同族体 | |
SK83697A3 (en) | Piperazine-2,5-dione derivatives as modulators of multi-drug resistance | |
WO2018005801A2 (en) | Novel non-systemic tgr5 agonists | |
KR20130086608A (ko) | 암 치료용 신규 n-하이드록시-벤즈아마이드 | |
KR20230171449A (ko) | 브루톤 티로신 키나제 억제제의 공결정질 형태 | |
KR100412167B1 (ko) | 다중약물내성의조절제로서의피페라진-2,5-디온유도체 | |
JP5330377B2 (ja) | 3,4−ジヒドロキナゾリン誘導体 | |
US20220267289A1 (en) | Selective bcrp/abcg2 transporter inhibitors as agents to abolish resistance to anti-cancer agents | |
US5861400A (en) | Pharmaceutical compounds | |
WO2016127949A1 (zh) | 作为t790变异抑制剂的嘧啶衍生物 | |
CN115052855A (zh) | 酰胺化合物的制备方法、其晶型及其盐类 | |
US20190240244A1 (en) | Compounds for cancer chemotherapeutic sensitization | |
EP4317143A1 (en) | Bicyclic heterocyclic fgfr4 inhibitor, pharmaceutical composition and preparation comprising same, and application thereof | |
SK286055B6 (sk) | Indenoindolónové zlúčeniny, spôsob ich prípravy afarmaceutické kompozície s ich obsahom |