SK17752000A3 - Farmaceutický prípravok - Google Patents
Farmaceutický prípravok Download PDFInfo
- Publication number
- SK17752000A3 SK17752000A3 SK1775-2000A SK17752000A SK17752000A3 SK 17752000 A3 SK17752000 A3 SK 17752000A3 SK 17752000 A SK17752000 A SK 17752000A SK 17752000 A3 SK17752000 A3 SK 17752000A3
- Authority
- SK
- Slovakia
- Prior art keywords
- benzoyl
- trifluoromethyl
- bis
- piperidinyl
- chlorobenzyl
- Prior art date
Links
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 19
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract description 21
- 239000003890 substance P antagonist Substances 0.000 title abstract description 6
- 239000000203 mixture Substances 0.000 claims description 64
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 43
- -1 3,5-bis (trifluoromethyl) benzoyl Chemical group 0.000 claims description 35
- 238000009472 formulation Methods 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 239000004094 surface-active agent Substances 0.000 claims description 23
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- 239000000194 fatty acid Substances 0.000 claims description 18
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- 238000000034 method Methods 0.000 claims description 5
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 4
- 239000001069 triethyl citrate Substances 0.000 claims description 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 4
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- NXLUTEDAEFXMQR-BJKOFHAPSA-N n-[(2r,4s)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]piperidin-4-yl]quinoline-4-carboxamide Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(C(=O)N2[C@@H](C[C@H](CC2)NC(=O)C=2C3=CC=CC=C3N=CC=2)CC=2C=CC(Cl)=CC=2)=C1 NXLUTEDAEFXMQR-BJKOFHAPSA-N 0.000 claims description 3
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- LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 claims 1
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- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 4
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811200.6A GB9811200D0 (en) | 1998-05-26 | 1998-05-26 | Organic compounds |
| GBGB9818105.0A GB9818105D0 (en) | 1998-08-19 | 1998-08-19 | Organic compounds |
| PCT/EP1999/003623 WO1999061025A1 (en) | 1998-05-26 | 1999-05-26 | Microemulsion preconcentrates containing a piperidine substance p antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK17752000A3 true SK17752000A3 (sk) | 2001-05-10 |
Family
ID=26313736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1775-2000A SK17752000A3 (sk) | 1998-05-26 | 1999-05-26 | Farmaceutický prípravok |
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| EP (1) | EP1082119B1 (enExample) |
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| CN (1) | CN1270714C (enExample) |
| AR (1) | AR018376A1 (enExample) |
| AT (1) | ATE257380T1 (enExample) |
| AU (1) | AU755134B2 (enExample) |
| BE (1) | BE1012143A5 (enExample) |
| BR (1) | BR9910696A (enExample) |
| CA (1) | CA2333154C (enExample) |
| DE (2) | DE19983247T1 (enExample) |
| DK (1) | DK1082119T3 (enExample) |
| ES (1) | ES2214859T3 (enExample) |
| FR (1) | FR2779145B1 (enExample) |
| GB (1) | GB2353473A (enExample) |
| HU (1) | HUP0102202A3 (enExample) |
| ID (1) | ID27096A (enExample) |
| IL (1) | IL139501A0 (enExample) |
| IT (1) | IT1313551B1 (enExample) |
| NO (1) | NO20005920L (enExample) |
| NZ (1) | NZ508325A (enExample) |
| PE (1) | PE20000537A1 (enExample) |
| PL (1) | PL344245A1 (enExample) |
| PT (1) | PT1082119E (enExample) |
| RU (1) | RU2240121C2 (enExample) |
| SK (1) | SK17752000A3 (enExample) |
| TR (1) | TR200003502T2 (enExample) |
| TW (1) | TW537894B (enExample) |
| WO (1) | WO1999061025A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW537894B (en) | 1998-05-26 | 2003-06-21 | Novartis Ag | A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist |
| US7202282B2 (en) * | 2002-04-22 | 2007-04-10 | University Of Florida | Microemulsions for selective molecular separation |
| GB0220953D0 (en) | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
| US7842791B2 (en) | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| FR2934953B1 (fr) | 2008-08-14 | 2011-01-21 | Commissariat Energie Atomique | Nanoemulsions de nanocristaux |
| FR2934954B1 (fr) | 2008-08-14 | 2011-07-22 | Commissariat Energie Atomique | Emulsion fluorescente de vert d'indocyanine |
| FR2934955B1 (fr) | 2008-08-14 | 2011-07-08 | Commissariat Energie Atomique | Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions |
| FR2935001B1 (fr) * | 2008-08-14 | 2011-12-30 | Commissariat Energie Atomique | Emulsion fluorescente |
| ES2969933T3 (es) | 2012-12-31 | 2024-05-23 | Jrx Biotechnology Inc | Formulaciones farmacéuticas tópicas líquidas en nanoemulsión |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3305689A1 (de) | 1983-02-18 | 1984-08-23 | Mack Chem Pharm | Pharmazeutische zubereitung mit retardwirkung |
| US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| DE4220616C2 (de) | 1992-06-24 | 1994-12-22 | Byk Gulden Lomberg Chem Fab | Dexniguldipin zur intravenösen Verabreichung |
| PT589843E (pt) | 1992-09-25 | 2002-04-29 | Novartis Ag | Composicoes farmaceuticas contendo ciclosporinas |
| GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
| AU696855B2 (en) * | 1994-03-18 | 1998-09-17 | Shire Laboratories, Inc. | Emulsified drug delivery systems |
| TW397825B (en) * | 1994-10-14 | 2000-07-11 | Novartis Ag | Aroyl-piperidine derivatives |
| GB2308545B (en) | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| MY129435A (en) * | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| FR2728165A1 (fr) * | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene |
| FR2728169A1 (fr) * | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
| DE69617226T2 (de) * | 1995-03-27 | 2002-07-25 | Hisamitsu Pharmaceutical Co., Inc. | Piperidinderivate. |
| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| AU2898297A (en) | 1996-05-24 | 1998-01-05 | Novartis Ag | Use of substance p antagonists for treating social phobia |
| TW537894B (en) | 1998-05-26 | 2003-06-21 | Novartis Ag | A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist |
-
1999
- 1999-05-24 TW TW088108449A patent/TW537894B/zh not_active IP Right Cessation
- 1999-05-24 AR ARP990102454A patent/AR018376A1/es not_active Application Discontinuation
- 1999-05-25 PE PE1999000436A patent/PE20000537A1/es not_active Application Discontinuation
- 1999-05-25 BE BE9900364A patent/BE1012143A5/fr not_active IP Right Cessation
- 1999-05-26 KR KR1020007012871A patent/KR20010043669A/ko not_active Ceased
- 1999-05-26 JP JP2000550485A patent/JP4083985B2/ja not_active Expired - Fee Related
- 1999-05-26 PL PL99344245A patent/PL344245A1/xx unknown
- 1999-05-26 GB GB0028506A patent/GB2353473A/en not_active Withdrawn
- 1999-05-26 IT IT1999MI001164A patent/IT1313551B1/it active
- 1999-05-26 AU AU45008/99A patent/AU755134B2/en not_active Ceased
- 1999-05-26 DE DE19983247T patent/DE19983247T1/de not_active Withdrawn
- 1999-05-26 BR BR9910696-5A patent/BR9910696A/pt not_active Application Discontinuation
- 1999-05-26 HU HU0102202A patent/HUP0102202A3/hu unknown
- 1999-05-26 NZ NZ508325A patent/NZ508325A/xx unknown
- 1999-05-26 CN CNB998066036A patent/CN1270714C/zh not_active Expired - Fee Related
- 1999-05-26 EP EP99927760A patent/EP1082119B1/en not_active Expired - Lifetime
- 1999-05-26 ID IDW20002316A patent/ID27096A/id unknown
- 1999-05-26 WO PCT/EP1999/003623 patent/WO1999061025A1/en not_active Ceased
- 1999-05-26 IL IL13950199A patent/IL139501A0/xx unknown
- 1999-05-26 ES ES99927760T patent/ES2214859T3/es not_active Expired - Lifetime
- 1999-05-26 SK SK1775-2000A patent/SK17752000A3/sk unknown
- 1999-05-26 FR FR9906629A patent/FR2779145B1/fr not_active Expired - Fee Related
- 1999-05-26 DK DK99927760T patent/DK1082119T3/da active
- 1999-05-26 TR TR2000/03502T patent/TR200003502T2/xx unknown
- 1999-05-26 CA CA002333154A patent/CA2333154C/en not_active Expired - Fee Related
- 1999-05-26 RU RU2000133308/15A patent/RU2240121C2/ru not_active IP Right Cessation
- 1999-05-26 DE DE69914077T patent/DE69914077T2/de not_active Expired - Lifetime
- 1999-05-26 AT AT99927760T patent/ATE257380T1/de not_active IP Right Cessation
- 1999-05-26 PT PT99927760T patent/PT1082119E/pt unknown
-
2000
- 2000-11-23 NO NO20005920A patent/NO20005920L/no not_active Application Discontinuation
-
2002
- 2002-04-10 US US10/119,549 patent/US20020156099A1/en not_active Abandoned
-
2003
- 2003-03-04 US US10/379,345 patent/US6949257B2/en not_active Expired - Fee Related
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