BE1012143A5 - Nouvelles compositions pharmaceutiques. - Google Patents
Nouvelles compositions pharmaceutiques. Download PDFInfo
- Publication number
- BE1012143A5 BE1012143A5 BE9900364A BE9900364A BE1012143A5 BE 1012143 A5 BE1012143 A5 BE 1012143A5 BE 9900364 A BE9900364 A BE 9900364A BE 9900364 A BE9900364 A BE 9900364A BE 1012143 A5 BE1012143 A5 BE 1012143A5
- Authority
- BE
- Belgium
- Prior art keywords
- pharmaceutical composition
- composition according
- spontaneously dispersible
- dispersible pharmaceutical
- piperidine
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 60
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000003890 substance P antagonist Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims description 72
- -1 3, 5-bis (trifluoromethyl) -benzoyl Chemical group 0.000 claims description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- 239000004094 surface-active agent Substances 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 23
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 23
- 239000000194 fatty acid Substances 0.000 claims description 23
- 229930195729 fatty acid Natural products 0.000 claims description 23
- 239000004530 micro-emulsion Substances 0.000 claims description 19
- 239000004480 active ingredient Substances 0.000 claims description 15
- 239000005557 antagonist Substances 0.000 claims description 15
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 claims description 13
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- 101800003906 Substance P Proteins 0.000 claims description 13
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- 235000013769 triethyl citrate Nutrition 0.000 claims description 4
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 3
- GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 claims description 3
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- KPUPBSZZGVEESV-UHFFFAOYSA-N n-(1-benzoyl-2-benzylpiperidin-4-yl)isoquinoline-1-carboxamide Chemical group N=1C=CC2=CC=CC=C2C=1C(=O)NC(C1)CCN(C(=O)C=2C=CC=CC=2)C1CC1=CC=CC=C1 KPUPBSZZGVEESV-UHFFFAOYSA-N 0.000 claims description 2
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- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811200.6A GB9811200D0 (en) | 1998-05-26 | 1998-05-26 | Organic compounds |
| GBGB9818105.0A GB9818105D0 (en) | 1998-08-19 | 1998-08-19 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1012143A5 true BE1012143A5 (fr) | 2000-05-02 |
Family
ID=26313736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE9900364A BE1012143A5 (fr) | 1998-05-26 | 1999-05-25 | Nouvelles compositions pharmaceutiques. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20020156099A1 (enExample) |
| EP (1) | EP1082119B1 (enExample) |
| JP (1) | JP4083985B2 (enExample) |
| KR (1) | KR20010043669A (enExample) |
| CN (1) | CN1270714C (enExample) |
| AR (1) | AR018376A1 (enExample) |
| AT (1) | ATE257380T1 (enExample) |
| AU (1) | AU755134B2 (enExample) |
| BE (1) | BE1012143A5 (enExample) |
| BR (1) | BR9910696A (enExample) |
| CA (1) | CA2333154C (enExample) |
| DE (2) | DE19983247T1 (enExample) |
| DK (1) | DK1082119T3 (enExample) |
| ES (1) | ES2214859T3 (enExample) |
| FR (1) | FR2779145B1 (enExample) |
| GB (1) | GB2353473A (enExample) |
| HU (1) | HUP0102202A3 (enExample) |
| ID (1) | ID27096A (enExample) |
| IL (1) | IL139501A0 (enExample) |
| IT (1) | IT1313551B1 (enExample) |
| NO (1) | NO20005920L (enExample) |
| NZ (1) | NZ508325A (enExample) |
| PE (1) | PE20000537A1 (enExample) |
| PL (1) | PL344245A1 (enExample) |
| PT (1) | PT1082119E (enExample) |
| RU (1) | RU2240121C2 (enExample) |
| SK (1) | SK17752000A3 (enExample) |
| TR (1) | TR200003502T2 (enExample) |
| TW (1) | TW537894B (enExample) |
| WO (1) | WO1999061025A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW537894B (en) | 1998-05-26 | 2003-06-21 | Novartis Ag | A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist |
| US7202282B2 (en) * | 2002-04-22 | 2007-04-10 | University Of Florida | Microemulsions for selective molecular separation |
| GB0220953D0 (en) | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
| US7842791B2 (en) | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| FR2934953B1 (fr) | 2008-08-14 | 2011-01-21 | Commissariat Energie Atomique | Nanoemulsions de nanocristaux |
| FR2934954B1 (fr) | 2008-08-14 | 2011-07-22 | Commissariat Energie Atomique | Emulsion fluorescente de vert d'indocyanine |
| FR2934955B1 (fr) | 2008-08-14 | 2011-07-08 | Commissariat Energie Atomique | Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions |
| FR2935001B1 (fr) * | 2008-08-14 | 2011-12-30 | Commissariat Energie Atomique | Emulsion fluorescente |
| ES2969933T3 (es) | 2012-12-31 | 2024-05-23 | Jrx Biotechnology Inc | Formulaciones farmacéuticas tópicas líquidas en nanoemulsión |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2278780A (en) * | 1993-05-27 | 1994-12-14 | Sandoz Ltd | Macrolide antibiotic emulsions |
| EP0707006A1 (de) * | 1994-10-14 | 1996-04-17 | Ciba-Geigy Ag | Aroyl-piperidin-Derivate |
| EP0722722A1 (fr) * | 1994-12-19 | 1996-07-24 | L'oreal | Utilisation d'un antagoniste de substance P pour le traitement des rougeurs cutanées d'origine neurogène |
| EP0826684A1 (en) * | 1995-03-27 | 1998-03-04 | Hisamitsu Pharmaceutical Co., Inc. | Piperidine derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3305689A1 (de) | 1983-02-18 | 1984-08-23 | Mack Chem Pharm | Pharmazeutische zubereitung mit retardwirkung |
| US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| DE4220616C2 (de) | 1992-06-24 | 1994-12-22 | Byk Gulden Lomberg Chem Fab | Dexniguldipin zur intravenösen Verabreichung |
| PT589843E (pt) | 1992-09-25 | 2002-04-29 | Novartis Ag | Composicoes farmaceuticas contendo ciclosporinas |
| AU696855B2 (en) * | 1994-03-18 | 1998-09-17 | Shire Laboratories, Inc. | Emulsified drug delivery systems |
| GB2308545B (en) | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| MY129435A (en) * | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| FR2728169A1 (fr) * | 1994-12-19 | 1996-06-21 | Oreal | Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales |
| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| AU2898297A (en) | 1996-05-24 | 1998-01-05 | Novartis Ag | Use of substance p antagonists for treating social phobia |
| TW537894B (en) | 1998-05-26 | 2003-06-21 | Novartis Ag | A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist |
-
1999
- 1999-05-24 TW TW088108449A patent/TW537894B/zh not_active IP Right Cessation
- 1999-05-24 AR ARP990102454A patent/AR018376A1/es not_active Application Discontinuation
- 1999-05-25 PE PE1999000436A patent/PE20000537A1/es not_active Application Discontinuation
- 1999-05-25 BE BE9900364A patent/BE1012143A5/fr not_active IP Right Cessation
- 1999-05-26 KR KR1020007012871A patent/KR20010043669A/ko not_active Ceased
- 1999-05-26 JP JP2000550485A patent/JP4083985B2/ja not_active Expired - Fee Related
- 1999-05-26 PL PL99344245A patent/PL344245A1/xx unknown
- 1999-05-26 GB GB0028506A patent/GB2353473A/en not_active Withdrawn
- 1999-05-26 IT IT1999MI001164A patent/IT1313551B1/it active
- 1999-05-26 AU AU45008/99A patent/AU755134B2/en not_active Ceased
- 1999-05-26 DE DE19983247T patent/DE19983247T1/de not_active Withdrawn
- 1999-05-26 BR BR9910696-5A patent/BR9910696A/pt not_active Application Discontinuation
- 1999-05-26 HU HU0102202A patent/HUP0102202A3/hu unknown
- 1999-05-26 NZ NZ508325A patent/NZ508325A/xx unknown
- 1999-05-26 CN CNB998066036A patent/CN1270714C/zh not_active Expired - Fee Related
- 1999-05-26 EP EP99927760A patent/EP1082119B1/en not_active Expired - Lifetime
- 1999-05-26 ID IDW20002316A patent/ID27096A/id unknown
- 1999-05-26 WO PCT/EP1999/003623 patent/WO1999061025A1/en not_active Ceased
- 1999-05-26 IL IL13950199A patent/IL139501A0/xx unknown
- 1999-05-26 ES ES99927760T patent/ES2214859T3/es not_active Expired - Lifetime
- 1999-05-26 SK SK1775-2000A patent/SK17752000A3/sk unknown
- 1999-05-26 FR FR9906629A patent/FR2779145B1/fr not_active Expired - Fee Related
- 1999-05-26 DK DK99927760T patent/DK1082119T3/da active
- 1999-05-26 TR TR2000/03502T patent/TR200003502T2/xx unknown
- 1999-05-26 CA CA002333154A patent/CA2333154C/en not_active Expired - Fee Related
- 1999-05-26 RU RU2000133308/15A patent/RU2240121C2/ru not_active IP Right Cessation
- 1999-05-26 DE DE69914077T patent/DE69914077T2/de not_active Expired - Lifetime
- 1999-05-26 AT AT99927760T patent/ATE257380T1/de not_active IP Right Cessation
- 1999-05-26 PT PT99927760T patent/PT1082119E/pt unknown
-
2000
- 2000-11-23 NO NO20005920A patent/NO20005920L/no not_active Application Discontinuation
-
2002
- 2002-04-10 US US10/119,549 patent/US20020156099A1/en not_active Abandoned
-
2003
- 2003-03-04 US US10/379,345 patent/US6949257B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2278780A (en) * | 1993-05-27 | 1994-12-14 | Sandoz Ltd | Macrolide antibiotic emulsions |
| EP0707006A1 (de) * | 1994-10-14 | 1996-04-17 | Ciba-Geigy Ag | Aroyl-piperidin-Derivate |
| EP0722722A1 (fr) * | 1994-12-19 | 1996-07-24 | L'oreal | Utilisation d'un antagoniste de substance P pour le traitement des rougeurs cutanées d'origine neurogène |
| EP0826684A1 (en) * | 1995-03-27 | 1998-03-04 | Hisamitsu Pharmaceutical Co., Inc. | Piperidine derivatives |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Effective date: 20110531 |