SK15692002A3 - 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie - Google Patents

3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie Download PDF

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Publication number
SK15692002A3
SK15692002A3 SK1569-2002A SK15692002A SK15692002A3 SK 15692002 A3 SK15692002 A3 SK 15692002A3 SK 15692002 A SK15692002 A SK 15692002A SK 15692002 A3 SK15692002 A3 SK 15692002A3
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Slovakia
Prior art keywords
compound
substituted
hydrogen
groups
group
Prior art date
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SK1569-2002A
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English (en)
Slovak (sk)
Inventor
Jeffrey R. Raymond
Claudia E. Kasserra
Yaping Shen
Original Assignee
Inflazyme Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharmaceuticals Limited filed Critical Inflazyme Pharmaceuticals Limited
Publication of SK15692002A3 publication Critical patent/SK15692002A3/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011Unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0047Nitrogen only at position 2(3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0057Nitrogen and oxygen
    • C07J71/0063Nitrogen and oxygen at position 2(3)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1569-2002A 2000-04-28 2001-04-30 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie SK15692002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20061700P 2000-04-28 2000-04-28
PCT/CA2001/000581 WO2001083512A1 (en) 2000-04-28 2001-04-30 3-nitrogen-6,7-dioxygen steroids and uses related thereto

Publications (1)

Publication Number Publication Date
SK15692002A3 true SK15692002A3 (sk) 2003-11-04

Family

ID=22742458

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1569-2002A SK15692002A3 (sk) 2000-04-28 2001-04-30 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie

Country Status (34)

Country Link
US (4) US20040034216A1 (xx)
EP (1) EP1278763B1 (xx)
JP (1) JP2003531916A (xx)
KR (1) KR20030045671A (xx)
CN (1) CN1214039C (xx)
AP (1) AP1825A (xx)
AT (1) ATE353909T1 (xx)
AU (2) AU5208401A (xx)
BG (1) BG107289A (xx)
BR (1) BR0110419A (xx)
CA (1) CA2418748A1 (xx)
CO (1) CO5590904A2 (xx)
DE (1) DE60126597T2 (xx)
DK (1) DK1278763T3 (xx)
DZ (1) DZ3355A1 (xx)
EE (1) EE200200613A (xx)
ES (1) ES2282247T3 (xx)
HK (1) HK1050694A1 (xx)
HR (1) HRP20020944A2 (xx)
HU (1) HUP0300908A2 (xx)
IL (2) IL152448A0 (xx)
MA (1) MA25808A1 (xx)
MX (1) MXPA02010645A (xx)
NO (1) NO324873B1 (xx)
NZ (1) NZ522181A (xx)
OA (1) OA12255A (xx)
PL (1) PL365798A1 (xx)
PT (1) PT1278763E (xx)
RU (1) RU2291873C2 (xx)
SK (1) SK15692002A3 (xx)
UA (1) UA79229C2 (xx)
WO (1) WO2001083512A1 (xx)
YU (1) YU88102A (xx)
ZA (1) ZA200208631B (xx)

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EP1404700A2 (en) 2001-05-22 2004-04-07 Inflazyme Pharmaceuticals, Ltd. Process for the production of 6,7-dihydroxy steroid compounds by allylic oxidation of steroid-5-ene compounds to steroid-5-ene-7-one compounds followed by hydroboration and oxidation and intermediates of this process
US7264935B2 (en) 2002-08-01 2007-09-04 Astellas Pharma Inc. Potassium-dependent sodium-calcium exchanger
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20110209699A1 (en) * 2003-07-31 2011-09-01 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
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US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
WO2005037851A1 (fr) * 2003-10-20 2005-04-28 Inflazyme Pharmaceuticals, Ltd. Formes cristallines du chlorhydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
FR2861077B1 (fr) * 2003-10-20 2006-03-03 Aventis Pharma Sa Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US20080051382A1 (en) * 2003-10-20 2008-02-28 Inflazyme Pharmaceuticals Ltd. Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride
US20050227927A1 (en) * 2004-03-31 2005-10-13 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20090317477A1 (en) * 2004-03-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
US20050222049A1 (en) * 2004-03-31 2005-10-06 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a glucocorticosteroid for treatment of asthma, chronic obstructive pulmonary disease or allergic rhinitis
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JP5655243B2 (ja) * 2009-10-19 2015-01-21 国立大学法人 熊本大学 インドキシル硫酸の産生の阻害剤のスクリーニング方法、インドキシル硫酸代謝産生阻害剤、及び腎障害軽減剤
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WO2012103810A1 (en) 2011-02-02 2012-08-09 Suzhou Neupharma Co., Ltd Certain chemical entities, compositions, and methods
US9340570B2 (en) 2012-04-29 2016-05-17 Neupharma, Inc. Certain chemical entities, compositions, and methods
TWI750197B (zh) 2012-09-25 2021-12-21 美商百歐維拉提夫治療公司 Fix多肽的應用
US9765085B2 (en) 2013-03-14 2017-09-19 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
CA2902764A1 (en) 2013-03-14 2014-09-18 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
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Also Published As

Publication number Publication date
YU88102A (sh) 2006-01-16
AP2002002659A0 (en) 2002-12-31
BR0110419A (pt) 2004-02-25
EP1278763B1 (en) 2007-02-14
JP2003531916A (ja) 2003-10-28
CO5590904A2 (es) 2005-12-30
NZ522181A (en) 2005-04-29
PT1278763E (pt) 2007-05-31
CN1430625A (zh) 2003-07-16
DE60126597D1 (de) 2007-03-29
NO20025106D0 (no) 2002-10-24
ZA200208631B (en) 2004-02-23
US7112580B2 (en) 2006-09-26
BG107289A (bg) 2003-07-31
EE200200613A (et) 2004-04-15
US20020072510A1 (en) 2002-06-13
DK1278763T3 (da) 2007-06-11
OA12255A (en) 2006-05-11
US20050215534A9 (en) 2005-09-29
CN1214039C (zh) 2005-08-10
RU2291873C2 (ru) 2007-01-20
UA79229C2 (en) 2007-06-11
MXPA02010645A (es) 2004-04-20
NO324873B1 (no) 2007-12-17
EP1278763A1 (en) 2003-01-29
ES2282247T3 (es) 2007-10-16
MA25808A1 (fr) 2003-07-01
HK1050694A1 (en) 2003-07-04
AP1825A (en) 2008-02-03
US20040034216A1 (en) 2004-02-19
ATE353909T1 (de) 2007-03-15
US20040138186A1 (en) 2004-07-15
HRP20020944A2 (en) 2004-02-29
DZ3355A1 (fr) 2001-11-08
AU2001252084B2 (en) 2006-07-06
HUP0300908A2 (hu) 2003-07-28
IL152448A (en) 2006-12-31
US20070060553A1 (en) 2007-03-15
US6635629B2 (en) 2003-10-21
PL365798A1 (en) 2005-01-10
NO20025106L (no) 2002-12-18
DE60126597T2 (de) 2007-10-31
WO2001083512A1 (en) 2001-11-08
AU5208401A (en) 2001-11-12
CA2418748A1 (en) 2001-11-08
KR20030045671A (ko) 2003-06-11
IL152448A0 (en) 2003-05-29

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