SK143998A3 - Specific immunophilin ligands as antiasthmatics and immunosuppressants - Google Patents
Specific immunophilin ligands as antiasthmatics and immunosuppressants Download PDFInfo
- Publication number
- SK143998A3 SK143998A3 SK1439-98A SK143998A SK143998A3 SK 143998 A3 SK143998 A3 SK 143998A3 SK 143998 A SK143998 A SK 143998A SK 143998 A3 SK143998 A3 SK 143998A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- indoline
- acid
- carboxylic acid
- boc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19616509A DE19616509A1 (de) | 1996-04-25 | 1996-04-25 | Neue spezifische Immunophilin-Liganden als Antiasthmatika, Immunsuppressiva |
| PCT/EP1997/001681 WO1997041148A1 (de) | 1996-04-25 | 1997-04-04 | Spezifische immunophilin-liganden als antiasthmatika, immunsuppressiva |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK143998A3 true SK143998A3 (en) | 1999-08-06 |
Family
ID=7792406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1439-98A SK143998A3 (en) | 1996-04-25 | 1997-04-04 | Specific immunophilin ligands as antiasthmatics and immunosuppressants |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6258815B1 (no) |
| EP (1) | EP0896580A1 (no) |
| JP (1) | JP3102895B2 (no) |
| KR (1) | KR20000065003A (no) |
| CN (1) | CN1214690A (no) |
| AU (1) | AU719840B2 (no) |
| BR (1) | BR9708869A (no) |
| CA (1) | CA2203466A1 (no) |
| CZ (1) | CZ297298A3 (no) |
| DE (1) | DE19616509A1 (no) |
| HU (1) | HUP9901588A3 (no) |
| IL (1) | IL125340A0 (no) |
| IS (1) | IS4808A (no) |
| NO (1) | NO984647L (no) |
| NZ (1) | NZ331180A (no) |
| PL (1) | PL329560A1 (no) |
| SK (1) | SK143998A3 (no) |
| TR (1) | TR199801949T2 (no) |
| WO (1) | WO1997041148A1 (no) |
| ZA (1) | ZA973121B (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19742263A1 (de) * | 1997-09-25 | 1999-04-01 | Asta Medica Ag | Neue spezifische Immunophilin-Liganden als Antiasthmatika, Antiallergika, Antirheumatika, Immunsuppressiva, Antipsoriatika, Neuroprotektiva |
| US6251932B1 (en) | 1998-09-25 | 2001-06-26 | Asta Medica Ag | Immunophilin ligands |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| CN112022846B (zh) * | 2020-09-23 | 2021-10-08 | 吕奔 | 一种吲哚啉衍生物在制备治疗脓毒症药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2585709B1 (fr) * | 1985-08-05 | 1987-10-02 | Adir | Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE3742431A1 (de) * | 1987-12-15 | 1989-07-13 | Hoechst Ag | Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung |
| JPH0712045B2 (ja) | 1988-03-02 | 1995-02-08 | 株式会社東海理化電機製作所 | 電流検出素子 |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| FR2681864B1 (fr) | 1991-09-27 | 1995-03-31 | Adir | Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JP3810097B2 (ja) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | ピロリジン−２−イルカルボニル複素環式化合物誘導体 |
| FR2703050B1 (fr) * | 1993-03-24 | 1995-04-28 | Adir | Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1996
- 1996-04-25 DE DE19616509A patent/DE19616509A1/de not_active Withdrawn
-
1997
- 1997-04-04 PL PL97329560A patent/PL329560A1/xx unknown
- 1997-04-04 JP JP09538489A patent/JP3102895B2/ja not_active Expired - Fee Related
- 1997-04-04 BR BR9708869A patent/BR9708869A/pt unknown
- 1997-04-04 KR KR1019980708534A patent/KR20000065003A/ko not_active Application Discontinuation
- 1997-04-04 HU HU9901588A patent/HUP9901588A3/hu unknown
- 1997-04-04 CZ CZ982972A patent/CZ297298A3/cs unknown
- 1997-04-04 IL IL12534097A patent/IL125340A0/xx unknown
- 1997-04-04 TR TR1998/01949T patent/TR199801949T2/xx unknown
- 1997-04-04 NZ NZ331180A patent/NZ331180A/xx unknown
- 1997-04-04 SK SK1439-98A patent/SK143998A3/sk unknown
- 1997-04-04 CN CN97193256A patent/CN1214690A/zh active Pending
- 1997-04-04 EP EP97916432A patent/EP0896580A1/de not_active Withdrawn
- 1997-04-04 AU AU25082/97A patent/AU719840B2/en not_active Ceased
- 1997-04-04 WO PCT/EP1997/001681 patent/WO1997041148A1/de not_active Application Discontinuation
- 1997-04-11 ZA ZA9703121A patent/ZA973121B/xx unknown
- 1997-04-23 CA CA002203466A patent/CA2203466A1/en not_active Abandoned
- 1997-04-25 US US08/847,639 patent/US6258815B1/en not_active Expired - Fee Related
-
1998
- 1998-07-24 IS IS4808A patent/IS4808A/is unknown
- 1998-10-05 NO NO984647A patent/NO984647L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901588A3 (en) | 2000-06-28 |
| AU719840B2 (en) | 2000-05-18 |
| JP2000500776A (ja) | 2000-01-25 |
| TR199801949T2 (xx) | 1999-02-22 |
| PL329560A1 (en) | 1999-03-29 |
| NZ331180A (en) | 2000-04-28 |
| NO984647D0 (no) | 1998-10-05 |
| CN1214690A (zh) | 1999-04-21 |
| ZA973121B (en) | 1997-11-05 |
| KR20000065003A (ko) | 2000-11-06 |
| CZ297298A3 (cs) | 1999-03-17 |
| IS4808A (is) | 1998-07-24 |
| AU2508297A (en) | 1997-11-19 |
| JP3102895B2 (ja) | 2000-10-23 |
| CA2203466A1 (en) | 1997-10-25 |
| US6258815B1 (en) | 2001-07-10 |
| EP0896580A1 (de) | 1999-02-17 |
| HUP9901588A2 (hu) | 1999-08-30 |
| IL125340A0 (en) | 1999-03-12 |
| DE19616509A1 (de) | 1998-01-15 |
| BR9708869A (pt) | 1999-08-03 |
| NO984647L (no) | 1998-10-05 |
| WO1997041148A1 (de) | 1997-11-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5710129A (en) | Inhibitors of SH2-mediated processes | |
| US8178575B2 (en) | Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV | |
| NO861141L (no) | Fremgangsmaate ved fremstilling av therapeutisk virksomme n,n[-dialkylguanidino-dipeptider. | |
| CN102844327B (zh) | 具有cxcr7 调节活性的模板固定的肽模拟物 | |
| CN1175259A (zh) | 低分子量双环凝血酶抑制剂 | |
| Lei et al. | Discovery of a novel dipeptidyl boronic acid proteasome inhibitor for the treatment of multiple myeloma and triple-negative breast cancer | |
| EP0610743A1 (en) | Novel aminomethylene-peptides as immunosuppressants | |
| US6251932B1 (en) | Immunophilin ligands | |
| Lesma et al. | Ugi 4-CR/Pictet–Spengler reaction as a short route to tryptophan-derived peptidomimetics | |
| CN102946726B (zh) | 新型降血糖化合物 | |
| Kobayashi et al. | Discovery of the orally effective Thyrotropin-Releasing Hormone mimetic: 1-{N-[(4 S, 5 S)-(5-Methyl-2-oxooxazolidine-4-yl) carbonyl]-3-(thiazol-4-yl)-L-alanyl}-(2 R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate) | |
| EP0753004A1 (en) | Antagonists of endothelin receptors | |
| JP2001517653A (ja) | 抗喘息薬、抗アレルギー薬、抗リウマチ薬、免疫抑制薬、抗乾癬薬、神経保護薬としての特異性イムノフィリン配位子 | |
| SK143998A3 (en) | Specific immunophilin ligands as antiasthmatics and immunosuppressants | |
| JP5634397B2 (ja) | ｐ２７のプロテアソーム分解の阻害物質である、アルギリン及びその誘導体等の新規の大環状化合物の製造の中間体を製造する方法、並びに上記大環状化合物の使用 | |
| RU2098424C1 (ru) | Производные дипептидов или их фармацевтически приемлемые соли, способы их получения, антигипертоническая фармацевтическая композиция | |
| Danilewicz et al. | Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence | |
| RU2172743C2 (ru) | Иммунофилин-специфические лиганды в качестве антиастматических и иммунодепрессантных агентов и способ их получения, фармацевтически готовая форма, лекарственное средство и способ его получения | |
| CA2527375C (en) | Beta-strand mimetics and methods relating thereto | |
| WO2008148279A1 (fr) | Dérivés de pyrrolidine condensés avec du cyclobutyle, leurs procédés de préparation et leur utilisation médicale | |
| Philipova et al. | Application of the ‘Direct Amide Cyclization’to Peptides Containing an Anthranilic Acid Residue | |
| CA2887420A1 (en) | Matrix metalloproteinase inhibitors and methods for the treatment of pain and other diseases | |
| WO2012017391A2 (en) | Novel compounds as dpp-iv inhibitors and process for preparation thereof | |
| MXPA99012020A (en) | Specific immunophilin ligands useful as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsoriatic and neuroprotective agents | |
| MXPA98008546A (en) | Specific binders of immunophylin as antimatic, immunosupreso |