HUP9901588A2 - Asztmaellenes és immunszupresszív hatású specifikus immunofilin-ligandumok - Google Patents
Asztmaellenes és immunszupresszív hatású specifikus immunofilin-ligandumokInfo
- Publication number
- HUP9901588A2 HUP9901588A2 HU9901588A HUP9901588A HUP9901588A2 HU P9901588 A2 HUP9901588 A2 HU P9901588A2 HU 9901588 A HU9901588 A HU 9901588A HU P9901588 A HUP9901588 A HU P9901588A HU P9901588 A2 HUP9901588 A2 HU P9901588A2
- Authority
- HU
- Hungary
- Prior art keywords
- acid
- pipe
- hydrogen atom
- grinder
- optionally substituted
- Prior art date
Links
- 102000000521 Immunophilins Human genes 0.000 title 1
- 108010016648 Immunophilins Proteins 0.000 title 1
- 230000001088 anti-asthma Effects 0.000 title 1
- 239000000924 antiasthmatic agent Substances 0.000 title 1
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 239000000843 powder Substances 0.000 abstract 4
- 239000004472 Lysine Substances 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- JJMDCOVWQOJGCB-UHFFFAOYSA-N 5-aminopentanoic acid Chemical compound [NH3+]CCCCC([O-])=O JJMDCOVWQOJGCB-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 oxycarbonyl- Chemical group 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- CNMAQBJBWQQZFZ-LURJTMIESA-N (2s)-2-(pyridin-2-ylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1=CC=CC=N1 CNMAQBJBWQQZFZ-LURJTMIESA-N 0.000 abstract 1
- UQXNEWQGGVUVQA-UHFFFAOYSA-N 8-aminooctanoic acid Chemical compound NCCCCCCCC(O)=O UQXNEWQGGVUVQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- QNRXNRGSOJZINA-UHFFFAOYSA-N indoline-2-carboxylic acid Chemical compound C1=CC=C2NC(C(=O)O)CC2=C1 QNRXNRGSOJZINA-UHFFFAOYSA-N 0.000 abstract 1
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 abstract 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- XJLSEXAGTJCILF-UHFFFAOYSA-N nipecotic acid Chemical compound OC(=O)C1CCCNC1 XJLSEXAGTJCILF-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány (I) általánős képletű vegyületekre vőnatkőzik, a képletben R1 jelentése hidrőgénatőm, adőtt esetben helyettesített alkil- vagyalkil-őxi-csőpőrt, aminősavak, így a hisztidin, leűcin, valin,szerin(Bzl), treőnin, pipekőlinsav, 4-piperidinkarbőnsav, 3-piperidinkarbőnsav, e-NH2-lizin, e-Z-NH-lizin, e-(2Cl-Z)-NH-lizin, 2-piridil-alanin, fenil-alanin, triptőfán, glűtaminsav, arginin(Tős),aszparagin, citrűllin, hőmőcitrűllin, őrnitin, prőlin, 2-indőlinkarbőnsav, őktahidrőindőlinkarbőnsav, tetrahidrőiző-kinőlinkarbőnsav, 5-aminő-valeriánsav, 8-aminő-őktán-sav metil-észtereiből származó aminmaradék; R2 jelentése hidrőgénatőm, adőtt esetben helyettesített alkil- vagyalkil-őxi-csőpőrt; R3 jelentése hidrőgénatőm, bűtőxi-karbőnil-, karbőxi-benzil-, mőnő-,bi- vagy triciklűsős karbőnil-aril- vagy 1-4 heterőatőmőt tartalmazókarbőnil-heterőarilcsőpőrt, ahől az aril-, illetve a heterőarilcsőpőrtadőtt esetben helyettesített, karbőxi-(1-6 szénatőmős alkil)-csőpőrt,amely adőtt esetben helyettesített, aminősavak savmaradéka, ahől azaminősav N-terminálisa savmaradékkal helyettesített lehet; R4 jelentése hidrőgénatőm, flűőratőm vagy -OR5 általánős képletűcsőpőrt, R5 jelentése hidrőgénatőm, ciklőalkilcsőpőrt, adőtt esetbenhelyettesített alkil- vagy karbőxi-alkil-csőpőrt; A jelentése arőmás csőpőrt, nem arőmás csőpőrt, arőmás heterőgyűrűscsőpőrt vagy nem arőmás heterőgyűrűs csőpőrt; B jelentése -CH2- csőpőrt, D jelentése -CH- csőpőrt, B-D jelentése -CH=C- csőpőrt, X jelentése őxigénatőm, kénatőm vagy H2, Y jelentése szénatőm vagy egyszeres vegyértékkötés. A vegyületekmeglepő módőn erősen kötődő imműnőfilin-mődűlátőrők, amelyekhőrdőzóhőz kötött főrmában patőgén imműnőfilinek főlyadékőkból,különösen testfőlyadékőkból való megkötésére alkalmazhatók. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19616509A DE19616509A1 (de) | 1996-04-25 | 1996-04-25 | Neue spezifische Immunophilin-Liganden als Antiasthmatika, Immunsuppressiva |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901588A2 true HUP9901588A2 (hu) | 1999-08-30 |
| HUP9901588A3 HUP9901588A3 (en) | 2000-06-28 |
Family
ID=7792406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901588A HUP9901588A3 (en) | 1996-04-25 | 1997-04-04 | Specific immunophilin ligands as antiasthmatics and immunosuppressants |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6258815B1 (hu) |
| EP (1) | EP0896580A1 (hu) |
| JP (1) | JP3102895B2 (hu) |
| KR (1) | KR20000065003A (hu) |
| CN (1) | CN1214690A (hu) |
| AU (1) | AU719840B2 (hu) |
| BR (1) | BR9708869A (hu) |
| CA (1) | CA2203466A1 (hu) |
| CZ (1) | CZ297298A3 (hu) |
| DE (1) | DE19616509A1 (hu) |
| HU (1) | HUP9901588A3 (hu) |
| IL (1) | IL125340A0 (hu) |
| IS (1) | IS4808A (hu) |
| NO (1) | NO984647D0 (hu) |
| NZ (1) | NZ331180A (hu) |
| PL (1) | PL329560A1 (hu) |
| SK (1) | SK143998A3 (hu) |
| TR (1) | TR199801949T2 (hu) |
| WO (1) | WO1997041148A1 (hu) |
| ZA (1) | ZA973121B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19742263A1 (de) * | 1997-09-25 | 1999-04-01 | Asta Medica Ag | Neue spezifische Immunophilin-Liganden als Antiasthmatika, Antiallergika, Antirheumatika, Immunsuppressiva, Antipsoriatika, Neuroprotektiva |
| US6251932B1 (en) | 1998-09-25 | 2001-06-26 | Asta Medica Ag | Immunophilin ligands |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| CN112022846B (zh) * | 2020-09-23 | 2021-10-08 | 吕奔 | 一种吲哚啉衍生物在制备治疗脓毒症药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2585709B1 (fr) * | 1985-08-05 | 1987-10-02 | Adir | Nouveaux derives peptidiques a structure lactonique ou cycloamidique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE3742431A1 (de) * | 1987-12-15 | 1989-07-13 | Hoechst Ag | Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung |
| JPH0712045B2 (ja) | 1988-03-02 | 1995-02-08 | 株式会社東海理化電機製作所 | 電流検出素子 |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| FR2681864B1 (fr) | 1991-09-27 | 1995-03-31 | Adir | Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JP3810097B2 (ja) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | ピロリジン−２−イルカルボニル複素環式化合物誘導体 |
| FR2703050B1 (fr) * | 1993-03-24 | 1995-04-28 | Adir | Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1996
- 1996-04-25 DE DE19616509A patent/DE19616509A1/de not_active Withdrawn
-
1997
- 1997-04-04 HU HU9901588A patent/HUP9901588A3/hu unknown
- 1997-04-04 IL IL12534097A patent/IL125340A0/xx unknown
- 1997-04-04 BR BR9708869A patent/BR9708869A/pt unknown
- 1997-04-04 KR KR1019980708534A patent/KR20000065003A/ko not_active Application Discontinuation
- 1997-04-04 PL PL97329560A patent/PL329560A1/xx unknown
- 1997-04-04 EP EP97916432A patent/EP0896580A1/de not_active Withdrawn
- 1997-04-04 JP JP09538489A patent/JP3102895B2/ja not_active Expired - Fee Related
- 1997-04-04 CZ CZ982972A patent/CZ297298A3/cs unknown
- 1997-04-04 AU AU25082/97A patent/AU719840B2/en not_active Ceased
- 1997-04-04 WO PCT/EP1997/001681 patent/WO1997041148A1/de not_active Application Discontinuation
- 1997-04-04 TR TR1998/01949T patent/TR199801949T2/xx unknown
- 1997-04-04 NZ NZ331180A patent/NZ331180A/xx unknown
- 1997-04-04 SK SK1439-98A patent/SK143998A3/sk unknown
- 1997-04-04 CN CN97193256A patent/CN1214690A/zh active Pending
- 1997-04-11 ZA ZA9703121A patent/ZA973121B/xx unknown
- 1997-04-23 CA CA002203466A patent/CA2203466A1/en not_active Abandoned
- 1997-04-25 US US08/847,639 patent/US6258815B1/en not_active Expired - Fee Related
-
1998
- 1998-07-24 IS IS4808A patent/IS4808A/is unknown
- 1998-10-05 NO NO984647A patent/NO984647D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997041148A1 (de) | 1997-11-06 |
| US6258815B1 (en) | 2001-07-10 |
| PL329560A1 (en) | 1999-03-29 |
| HUP9901588A3 (en) | 2000-06-28 |
| CN1214690A (zh) | 1999-04-21 |
| NO984647L (no) | 1998-10-05 |
| NO984647D0 (no) | 1998-10-05 |
| AU2508297A (en) | 1997-11-19 |
| IL125340A0 (en) | 1999-03-12 |
| JP2000500776A (ja) | 2000-01-25 |
| KR20000065003A (ko) | 2000-11-06 |
| DE19616509A1 (de) | 1998-01-15 |
| IS4808A (is) | 1998-07-24 |
| JP3102895B2 (ja) | 2000-10-23 |
| AU719840B2 (en) | 2000-05-18 |
| BR9708869A (pt) | 1999-08-03 |
| SK143998A3 (en) | 1999-08-06 |
| CA2203466A1 (en) | 1997-10-25 |
| NZ331180A (en) | 2000-04-28 |
| TR199801949T2 (xx) | 1999-02-22 |
| CZ297298A3 (cs) | 1999-03-17 |
| EP0896580A1 (de) | 1999-02-17 |
| ZA973121B (en) | 1997-11-05 |
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