SK139194A3 - The improved antiandrogens - Google Patents
The improved antiandrogens Download PDFInfo
- Publication number
- SK139194A3 SK139194A3 SK1391-94A SK139194A SK139194A3 SK 139194 A3 SK139194 A3 SK 139194A3 SK 139194 A SK139194 A SK 139194A SK 139194 A3 SK139194 A3 SK 139194A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ring
- separated
- atoms
- mediating
- carbon atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0044—Alkenyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0048—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6061293A | 1993-05-17 | 1993-05-17 | |
| PCT/CA1993/000216 WO1994026767A1 (en) | 1993-05-17 | 1993-05-20 | Improved antiandrogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK139194A3 true SK139194A3 (en) | 1995-07-11 |
Family
ID=22030624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1391-94A SK139194A3 (en) | 1993-05-17 | 1993-05-20 | The improved antiandrogens |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0650495B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2741286B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100241228B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE197458T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2136303A1 (cg-RX-API-DMAC7.html) |
| CZ (2) | CZ285893B6 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69329649D1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI945458L (cg-RX-API-DMAC7.html) |
| HU (1) | HUT69408A (cg-RX-API-DMAC7.html) |
| PL (1) | PL307333A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2141966C1 (cg-RX-API-DMAC7.html) |
| SK (1) | SK139194A3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW259791B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1994026767A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5879711A (en) * | 1997-11-07 | 1999-03-09 | Sequeira; Joel A. | Stable antiandrogenic gel composition |
| MXPA00008868A (es) | 1998-03-11 | 2003-04-25 | Endorech Inc | Inhibidores de dihidrogenasa de 17 -hidroxiesteroide y metodos para su uso. |
| WO2002089802A2 (en) | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| MY141661A (en) | 2001-09-06 | 2010-05-31 | Schering Corp | 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| ES2347643T3 (es) | 2001-10-17 | 2010-11-03 | Schering Corporation | Piperin- y piperazinacetamidas como inhibidores de 17beta hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
| AU2003219656B2 (en) * | 2002-01-15 | 2007-05-17 | Merck Sharp & Dohme Corp. | 17-hydroxy-4-aza-androstan-3-ones as androgen receptor modulators |
| ES2345146T3 (es) | 2002-11-18 | 2010-09-16 | Schering Corporation | Inhibidores de 17beta-hidroxiesteroides deshidrogenasa de tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
| AU2003293555A1 (en) | 2002-12-17 | 2004-07-29 | Schering Corporation | 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1081494A (en) * | 1965-09-14 | 1967-08-31 | British Drug Houses Ltd | 17ª-(alka-1',3'-diynyl)-steroids |
| US3875188A (en) * | 1968-04-10 | 1975-04-01 | Eugene E Galantay | 17-Beta-alpha-lower alkyl allene-substituted steroids |
| JPS5513273A (en) * | 1978-07-13 | 1980-01-30 | Kanebo Ltd | Readily absorbable thiazolidine prodrug of anti- inflammatory corticosteroid and its drug composition |
| FR2430952A1 (fr) * | 1978-07-13 | 1980-02-08 | Roussel Uclaf | Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament |
| JP2959839B2 (ja) * | 1989-07-07 | 1999-10-06 | アンドルシェルシュ・インコーポレイテッド | 性ステロイド活性の抑制における使用のためのアンドロゲン誘導体 |
-
1993
- 1993-05-20 CZ CZ942824A patent/CZ285893B6/cs not_active IP Right Cessation
- 1993-05-20 JP JP6501832A patent/JP2741286B2/ja not_active Expired - Lifetime
- 1993-05-20 AT AT93909730T patent/ATE197458T1/de not_active IP Right Cessation
- 1993-05-20 KR KR1019940704184A patent/KR100241228B1/ko not_active Expired - Fee Related
- 1993-05-20 CA CA002136303A patent/CA2136303A1/en not_active Abandoned
- 1993-05-20 WO PCT/CA1993/000216 patent/WO1994026767A1/en not_active Ceased
- 1993-05-20 PL PL93307333A patent/PL307333A1/xx unknown
- 1993-05-20 HU HU9403262A patent/HUT69408A/hu unknown
- 1993-05-20 RU RU94046463A patent/RU2141966C1/ru active
- 1993-05-20 EP EP93909730A patent/EP0650495B1/en not_active Expired - Lifetime
- 1993-05-20 SK SK1391-94A patent/SK139194A3/sk unknown
- 1993-05-20 DE DE69329649T patent/DE69329649D1/de not_active Expired - Lifetime
- 1993-05-20 FI FI945458A patent/FI945458L/fi unknown
- 1993-05-21 TW TW082104024A patent/TW259791B/zh active
-
1999
- 1999-05-31 CZ CZ19991917A patent/CZ287991B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW259791B (cg-RX-API-DMAC7.html) | 1995-10-11 |
| WO1994026767A1 (en) | 1994-11-24 |
| RU94046463A (ru) | 1997-02-27 |
| CZ282494A3 (en) | 1995-12-13 |
| CZ287991B6 (cs) | 2001-03-14 |
| FI945458A0 (fi) | 1994-11-21 |
| EP0650495A1 (en) | 1995-05-03 |
| KR100241228B1 (ko) | 2000-02-01 |
| RU2141966C1 (ru) | 1999-11-27 |
| PL307333A1 (en) | 1995-05-15 |
| JP2741286B2 (ja) | 1998-04-15 |
| FI945458A7 (fi) | 1995-01-16 |
| ATE197458T1 (de) | 2000-11-11 |
| EP0650495B1 (en) | 2000-11-08 |
| CA2136303A1 (en) | 1994-11-24 |
| DE69329649D1 (de) | 2000-12-14 |
| FI945458L (fi) | 1995-01-16 |
| HUT69408A (en) | 1995-09-28 |
| JPH08510988A (ja) | 1996-11-19 |
| CZ285893B6 (cs) | 1999-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9284345B2 (en) | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators | |
| KR101536701B1 (ko) | 헬릭스 12 배향형 스테로이드계 약학 제품 | |
| RU2141967C1 (ru) | ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ | |
| EA002623B1 (ru) | 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ | |
| JPH02243698A (ja) | 性ステロイド活性を抑制するために用いるエストロゲン核誘導体の薬学組成物 | |
| JP2741286B2 (ja) | 改良された抗アンドロゲン | |
| US6015806A (en) | Antiandrogens | |
| WO2002000681A1 (en) | 20-fluoro-17(20)-vinyl steroids as inhibitors of c17-20-lyase and 5-alpha reductase | |
| SK882003A3 (en) | 16alpha-substituted steroid compounds, pharmaceutical composition comprising same and their use | |
| US6413951B2 (en) | 20-fluoro-17(20)-vinyl steroids | |
| AU718358B2 (en) | Inhibitors of testosterone 5-alpha reductase activity | |
| NZ280175A (en) | Inhibiting testosterone 5alpha-reductase activity using an A ring modified 4-aza-3-oxo-cyclopentanoperhydrophenarthrene substituted in position-17beta by amino or acylamino | |
| AU2004200173A1 (en) | Inhibitors of Type 5 and Type 3 17B-Hydroxysteroid Dehydrogenase and Methods for Their Use | |
| MXPA96003476A (es) | Derivados de 11-(fenilo sustituido)-estra-4,9-dieno |