SK13412000A3 - Deriváty benzofuryl-alfa-pyrónu, farmaceutické prostriedky, synergisty, inhibítory a činidlá - Google Patents

Deriváty benzofuryl-alfa-pyrónu, farmaceutické prostriedky, synergisty, inhibítory a činidlá Download PDF

Info

Publication number
SK13412000A3
SK13412000A3 SK1341-2000A SK13412000A SK13412000A3 SK 13412000 A3 SK13412000 A3 SK 13412000A3 SK 13412000 A SK13412000 A SK 13412000A SK 13412000 A3 SK13412000 A3 SK 13412000A3
Authority
SK
Slovakia
Prior art keywords
carbon atoms
heterocycle
group
pyran
dimethyl
Prior art date
Application number
SK1341-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Yoshimitsu Naniwa
Hiroshi Imai
Tomohide Ida
Emiko Muratani
Kazuo Kitai
Yoshinori Sugimoto
Tomomi Kosugi
Akiko Takeuchi
Kunihito Watanabe
Takami Tomiyama
Tomio Takeuchi
Masa Hamada
Original Assignee
Teijin Limited
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Limited, Microbial Chemistry Research Foundation filed Critical Teijin Limited
Publication of SK13412000A3 publication Critical patent/SK13412000A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
SK1341-2000A 1998-03-12 1999-03-12 Deriváty benzofuryl-alfa-pyrónu, farmaceutické prostriedky, synergisty, inhibítory a činidlá SK13412000A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6135698 1998-03-12
PCT/JP1999/001225 WO1999046262A1 (fr) 1998-03-12 1999-03-12 Derives de benzofurylpyrone

Publications (1)

Publication Number Publication Date
SK13412000A3 true SK13412000A3 (sk) 2001-04-09

Family

ID=13168805

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1341-2000A SK13412000A3 (sk) 1998-03-12 1999-03-12 Deriváty benzofuryl-alfa-pyrónu, farmaceutické prostriedky, synergisty, inhibítory a činidlá

Country Status (25)

Country Link
US (2) US6589984B1 (is)
EP (1) EP1063235B1 (is)
JP (1) JP3922884B2 (is)
KR (1) KR100595332B1 (is)
CN (1) CN1170827C (is)
AT (1) ATE266659T1 (is)
AU (1) AU756965B2 (is)
BG (1) BG104761A (is)
BR (1) BR9908706A (is)
CA (1) CA2323456A1 (is)
DE (1) DE69917237T2 (is)
EE (1) EE200000504A (is)
HR (1) HRP20000600A2 (is)
HU (1) HUP0101381A3 (is)
ID (1) ID27511A (is)
IL (1) IL138279A0 (is)
IS (1) IS5617A (is)
NO (1) NO20004517D0 (is)
NZ (1) NZ506802A (is)
PL (1) PL343419A1 (is)
RU (1) RU2199536C2 (is)
SK (1) SK13412000A3 (is)
TR (1) TR200002642T2 (is)
UA (1) UA58587C2 (is)
WO (1) WO1999046262A1 (is)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908706A (pt) * 1998-03-12 2000-11-21 Teijin Ltd Derivado de benzofuril-alfa-pirona, composição farmacêutica, acentuador de metabolismo de lipìdeos, inibidor de biossìntese de triglicerìdeos, agente redutor de triglicerìdeos do sangue, agente elevador de hdl do sangue, agente profilático para a arteriosclerose, e, agente de tratamento para a arteriosclerose
WO2002020500A2 (en) * 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
DE10115408A1 (de) * 2001-03-29 2002-10-02 Bayer Ag Benzofuran-Derivate
MXPA04007809A (es) * 2002-02-25 2004-10-15 Kudos Pharm Ltd Piranonas utiles como inhibidores de ataxia-telangetaxia mutada.
DE10314610A1 (de) 2003-04-01 2004-11-04 Aventis Pharma Deutschland Gmbh Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102007063671A1 (de) * 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CN102482312A (zh) 2009-08-26 2012-05-30 赛诺菲 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
DE102014214016A1 (de) 2014-07-18 2015-11-05 Deutsches Zentrum für Luft- und Raumfahrt e.V. Leichtbaustruktur und Verfahren zur Herstellung einer Leichtbaustruktur
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668803A (en) 1984-05-10 1987-05-26 Atlantic Richfield Company Benzafuran derivatives
DE4308451A1 (de) 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
ZA938019B (en) 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5808062A (en) 1993-11-19 1998-09-15 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
BR9908706A (pt) * 1998-03-12 2000-11-21 Teijin Ltd Derivado de benzofuril-alfa-pirona, composição farmacêutica, acentuador de metabolismo de lipìdeos, inibidor de biossìntese de triglicerìdeos, agente redutor de triglicerìdeos do sangue, agente elevador de hdl do sangue, agente profilático para a arteriosclerose, e, agente de tratamento para a arteriosclerose

Also Published As

Publication number Publication date
US6589984B1 (en) 2003-07-08
NZ506802A (en) 2002-11-26
DE69917237D1 (de) 2004-06-17
HUP0101381A3 (en) 2002-06-28
KR20010041776A (ko) 2001-05-25
ID27511A (id) 2001-04-12
KR100595332B1 (ko) 2006-07-03
EP1063235B1 (en) 2004-05-12
NO20004517L (no) 2000-09-11
EP1063235A1 (en) 2000-12-27
CN1170827C (zh) 2004-10-13
CN1299359A (zh) 2001-06-13
AU3277399A (en) 1999-09-27
NO20004517D0 (no) 2000-09-11
IL138279A0 (en) 2001-10-31
EP1063235A4 (en) 2003-01-07
ATE266659T1 (de) 2004-05-15
CA2323456A1 (en) 1999-09-16
HRP20000600A2 (en) 2001-06-30
EE200000504A (et) 2002-02-15
TR200002642T2 (tr) 2001-01-22
JP3922884B2 (ja) 2007-05-30
BR9908706A (pt) 2000-11-21
PL343419A1 (en) 2001-08-13
WO1999046262A1 (fr) 1999-09-16
IS5617A (is) 2000-09-08
DE69917237T2 (de) 2005-05-04
HUP0101381A2 (hu) 2002-05-29
UA58587C2 (uk) 2003-08-15
RU2199536C2 (ru) 2003-02-27
US20030186976A1 (en) 2003-10-02
BG104761A (en) 2001-08-31
AU756965B2 (en) 2003-01-30

Similar Documents

Publication Publication Date Title
SK13412000A3 (sk) Deriváty benzofuryl-alfa-pyrónu, farmaceutické prostriedky, synergisty, inhibítory a činidlá
US10626095B2 (en) Cyanotriazole compounds
JP6603712B2 (ja) Sumo活性化酵素の阻害薬として有用なヘテロアリール化合物
US8222261B2 (en) Chemical compounds
NL2000581C2 (nl) Aangecondenseerde fenylamidoheterocyclische verbindingen.
CN103153968B (zh) 三唑衍生物及含有其的具有镇痛作用的药物组合物
US9205077B2 (en) 2-alkoxy-substituted dicyanopyridines and their use
EP1107973B1 (en) NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY
MXPA02001565A (es) Inhibidores de cinasas c-jun n-terminal (jnk) y de otras cinasas proteicas.
KR20090097184A (ko) 비시클릭 화합물 및 항당뇨병제로서의 용도
KR20160078286A (ko) Gpr120 효능제로서의 바이아릴 유도체
KR20170063937A (ko) 제2형 당뇨병 치료용 gpr40 작용제로서의 치환된 벤조티오페닐 유도체
KR20230124926A (ko) Trpm3 매개 장애를 치료하기 위한 헤테로사이클 유도체
JP2009542641A (ja) 新規ピリジン類縁体
TW201427968A (zh) 芳香環化合物
JP2000128878A (ja) ベンゾフリル−α−ピリドン誘導体
CZ20003191A3 (cs) Deriváty benzofuryl-alfa-pyronu, farmaceutické prostředky, synergisté, inhibitory a činidla
MXPA00008781A (en) Benzofurylpyrone derivatives
BR112016000792B1 (pt) Compostos cianotriazol, seu uso, e agente profilático e/ou terapêutico
TW201350491A (zh) 雙環化合物