TR200002642T2 - Benzofurilpiron türevleri - Google Patents

Benzofurilpiron türevleri

Info

Publication number
TR200002642T2
TR200002642T2 TR2000/02642T TR200002642T TR200002642T2 TR 200002642 T2 TR200002642 T2 TR 200002642T2 TR 2000/02642 T TR2000/02642 T TR 2000/02642T TR 200002642 T TR200002642 T TR 200002642T TR 200002642 T2 TR200002642 T2 TR 200002642T2
Authority
TR
Turkey
Prior art keywords
derivatives
benzofurylpyrone
alkyl
represents hydrogen
hydrogen
Prior art date
Application number
TR2000/02642T
Other languages
English (en)
Inventor
Naniwa Yoshimitsu
Imai Hiroshi
Ida Tomohide
Muratani Emiko
Kitai Kazuo
Sugimoto Yoshinori
Kosugi Tomomi
Takeuchi Akiko
Watanabe Kunihito
Tomiyama Takami
Takeuchi Tomio
Hamada Masa
Original Assignee
Teijin Limited
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Limited, Microbial Chemistry Research Foundation filed Critical Teijin Limited
Publication of TR200002642T2 publication Critical patent/TR200002642T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • External Artificial Organs (AREA)
  • Furan Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Genel formül (1) ile gösterilmekte olan benzofuril-alfa-piron türevleri ya da bunlarin tuzlari, R1 hidrojen ya da C1-5 alkili temsil eder; R2 hidrojeni, -CO-R5'i ya da SO2R6'yi temsil eder; R3 hidrojeni, C1-5 alkil'i, vs.'yi temsil eder; ve R4 benzofuran halkasinin 4-,5-,6- ya da 7- pozisyonuna baglanmis olan belirli bir yapiya sahip bir degiskendir.
TR2000/02642T 1998-03-12 1999-03-12 Benzofurilpiron türevleri TR200002642T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6135698 1998-03-12

Publications (1)

Publication Number Publication Date
TR200002642T2 true TR200002642T2 (tr) 2001-01-22

Family

ID=13168805

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02642T TR200002642T2 (tr) 1998-03-12 1999-03-12 Benzofurilpiron türevleri

Country Status (25)

Country Link
US (2) US6589984B1 (tr)
EP (1) EP1063235B1 (tr)
JP (1) JP3922884B2 (tr)
KR (1) KR100595332B1 (tr)
CN (1) CN1170827C (tr)
AT (1) ATE266659T1 (tr)
AU (1) AU756965B2 (tr)
BG (1) BG104761A (tr)
BR (1) BR9908706A (tr)
CA (1) CA2323456A1 (tr)
DE (1) DE69917237T2 (tr)
EE (1) EE200000504A (tr)
HR (1) HRP20000600A2 (tr)
HU (1) HUP0101381A3 (tr)
ID (1) ID27511A (tr)
IL (1) IL138279A0 (tr)
IS (1) IS5617A (tr)
NO (1) NO20004517L (tr)
NZ (1) NZ506802A (tr)
PL (1) PL343419A1 (tr)
RU (1) RU2199536C2 (tr)
SK (1) SK13412000A3 (tr)
TR (1) TR200002642T2 (tr)
UA (1) UA58587C2 (tr)
WO (1) WO1999046262A1 (tr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID27511A (id) * 1998-03-12 2001-04-12 Teijin Ltd Turunan-turunan benzofurilpiron
EP1351946A2 (en) * 2000-09-01 2003-10-15 Icos Corporation Materials and methods to potentiate cancer treatment
DE10115408A1 (de) * 2001-03-29 2002-10-02 Bayer Ag Benzofuran-Derivate
BR0307944A (pt) * 2002-02-25 2005-02-01 Kudos Pharm Ltd Piranonas úteis como inibidores de atm
DE10314610A1 (de) 2003-04-01 2004-11-04 Aventis Pharma Deutschland Gmbh Neues Diphenylazetidinon mit verbesserten physiologischen Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindungen enthaltende Arzneimittel und dessen Verwendung
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102007063671A1 (de) * 2007-11-13 2009-06-25 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US8785608B2 (en) 2009-08-26 2014-07-22 Sanofi Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2683701B1 (de) 2011-03-08 2014-12-24 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120057A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
DE102014214016A1 (de) 2014-07-18 2015-11-05 Deutsches Zentrum für Luft- und Raumfahrt e.V. Leichtbaustruktur und Verfahren zur Herstellung einer Leichtbaustruktur
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668803A (en) * 1984-05-10 1987-05-26 Atlantic Richfield Company Benzafuran derivatives
DE4308451A1 (de) 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
ZA938019B (en) 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5808062A (en) 1993-11-19 1998-09-15 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
ID27511A (id) * 1998-03-12 2001-04-12 Teijin Ltd Turunan-turunan benzofurilpiron

Also Published As

Publication number Publication date
BG104761A (en) 2001-08-31
WO1999046262A1 (fr) 1999-09-16
NO20004517D0 (no) 2000-09-11
IS5617A (is) 2000-09-08
IL138279A0 (en) 2001-10-31
KR20010041776A (ko) 2001-05-25
NO20004517L (no) 2000-09-11
HUP0101381A3 (en) 2002-06-28
AU3277399A (en) 1999-09-27
BR9908706A (pt) 2000-11-21
JP3922884B2 (ja) 2007-05-30
HUP0101381A2 (hu) 2002-05-29
UA58587C2 (uk) 2003-08-15
EP1063235A4 (en) 2003-01-07
KR100595332B1 (ko) 2006-07-03
RU2199536C2 (ru) 2003-02-27
PL343419A1 (en) 2001-08-13
US6589984B1 (en) 2003-07-08
EP1063235A1 (en) 2000-12-27
AU756965B2 (en) 2003-01-30
ATE266659T1 (de) 2004-05-15
DE69917237T2 (de) 2005-05-04
US20030186976A1 (en) 2003-10-02
CA2323456A1 (en) 1999-09-16
SK13412000A3 (sk) 2001-04-09
CN1170827C (zh) 2004-10-13
DE69917237D1 (de) 2004-06-17
ID27511A (id) 2001-04-12
HRP20000600A2 (en) 2001-06-30
NZ506802A (en) 2002-11-26
EE200000504A (et) 2002-02-15
CN1299359A (zh) 2001-06-13
EP1063235B1 (en) 2004-05-12

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