SK13012001A3 - N-(2-Fenyl-4-amino-butyl)-1-naftamidy ako antagonisty receptora neurokinínu-1 - Google Patents
N-(2-Fenyl-4-amino-butyl)-1-naftamidy ako antagonisty receptora neurokinínu-1 Download PDFInfo
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- SK13012001A3 SK13012001A3 SK1301-2001A SK13012001A SK13012001A3 SK 13012001 A3 SK13012001 A3 SK 13012001A3 SK 13012001 A SK13012001 A SK 13012001A SK 13012001 A3 SK13012001 A3 SK 13012001A3
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- cyano
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- alkyl
- methyl
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- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical class [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 108010078913 substance P (6-11) Proteins 0.000 description 1
- 239000003890 substance P antagonist Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical group CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- LJJKNPQAGWVLDQ-SNVBAGLBSA-N thiorphan Chemical compound OC(=O)CNC(=O)[C@@H](CS)CC1=CC=CC=C1 LJJKNPQAGWVLDQ-SNVBAGLBSA-N 0.000 description 1
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9907571.5A GB9907571D0 (en) | 1999-04-06 | 1999-04-06 | Compounds |
| PCT/GB2000/001252 WO2000059873A1 (fr) | 1999-04-06 | 2000-04-03 | N-(2-phenyl-4-amino-butyl)-1-naphthamides en tant qu'antagonistes du recepteur de la neurokinine-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK13012001A3 true SK13012001A3 (sk) | 2002-04-04 |
Family
ID=10850835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1301-2001A SK13012001A3 (sk) | 1999-04-06 | 2000-04-03 | N-(2-Fenyl-4-amino-butyl)-1-naftamidy ako antagonisty receptora neurokinínu-1 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6476077B1 (fr) |
| EP (1) | EP1169302B1 (fr) |
| JP (1) | JP2002541137A (fr) |
| KR (1) | KR20010102580A (fr) |
| CN (2) | CN1534017A (fr) |
| AT (1) | ATE277893T1 (fr) |
| AU (1) | AU3569200A (fr) |
| BG (1) | BG106074A (fr) |
| BR (1) | BR0009582A (fr) |
| CA (1) | CA2368240A1 (fr) |
| CZ (1) | CZ20013574A3 (fr) |
| DE (1) | DE60014343T2 (fr) |
| EE (1) | EE200100520A (fr) |
| GB (1) | GB9907571D0 (fr) |
| HK (1) | HK1044145A1 (fr) |
| HU (1) | HUP0200707A3 (fr) |
| IL (1) | IL145645A0 (fr) |
| IS (1) | IS6087A (fr) |
| NO (1) | NO20014855L (fr) |
| PL (1) | PL350568A1 (fr) |
| SK (1) | SK13012001A3 (fr) |
| TR (1) | TR200102875T2 (fr) |
| UA (1) | UA67839C2 (fr) |
| WO (1) | WO2000059873A1 (fr) |
| ZA (1) | ZA200108176B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9907571D0 (en) * | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
| GB0019008D0 (en) * | 2000-08-04 | 2000-09-27 | Astrazeneca Ab | Therapeutic compounds |
| SE0201938D0 (sv) * | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New process |
| KR20050072786A (ko) * | 2002-11-05 | 2005-07-12 | 아스트라제네카 아베 | 잠금 덮개를 갖는 안전 용기 및 덮개를 잠그는 방법 |
| US20060058352A1 (en) * | 2002-12-20 | 2006-03-16 | Peter Bernstein | Piperidine amine compounds and their use |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| CA2580694A1 (fr) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methodes permettant de reguler les systemes de neurotransmetteurs en induisant des contre-adaptations |
| ES2672099T3 (es) | 2011-07-04 | 2018-06-12 | Irbm - Science Park S.P.A. | Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal |
| MX2017012720A (es) | 2015-05-18 | 2018-02-09 | Nerre Therapeutics Ltd | Antagonistas duales de receptores de neurocinina-1 (nk-1) / neurocinina-3 (nk-3) para el tratamiento de enfermedades dependientes de hormonas sexuales. |
| US20210015834A1 (en) | 2018-02-26 | 2021-01-21 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
| MA51999B1 (fr) | 2018-03-14 | 2024-02-29 | Kandy Therapeutics Ltd | Nouvelle formulation pharmaceutique comprenant deux antagonistes recepteurs de nk-1/nk-3. |
| RU2697414C1 (ru) | 2018-05-11 | 2019-08-14 | Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" | Новый антагонист тахикининовых рецепторов и его применение |
| US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| CA2163995A1 (fr) * | 1993-06-07 | 1994-12-22 | Malcolm Maccoss | Derives de substitution spiro d'azacycles, antagonistes de la neurokinine |
| DK0777659T3 (da) * | 1994-08-15 | 2001-09-03 | Merck Sharp & Dohme | Morpholinderivater og deres anvendelse som terapeutiske midler |
| AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
| GB9907571D0 (en) * | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
| WO2002076929A1 (fr) * | 2001-03-21 | 2002-10-03 | Pharmacopeia, Inc. | Composes d'aryle et de biaryle ayant une activite modulatrice de mch |
-
1999
- 1999-04-06 GB GBGB9907571.5A patent/GB9907571D0/en not_active Ceased
-
2000
- 2000-03-04 UA UA2001117535A patent/UA67839C2/uk unknown
- 2000-04-03 CZ CZ20013574A patent/CZ20013574A3/cs unknown
- 2000-04-03 CA CA002368240A patent/CA2368240A1/fr not_active Abandoned
- 2000-04-03 BR BR0009582-6A patent/BR0009582A/pt not_active IP Right Cessation
- 2000-04-03 EE EEP200100520A patent/EE200100520A/xx unknown
- 2000-04-03 WO PCT/GB2000/001252 patent/WO2000059873A1/fr not_active Application Discontinuation
- 2000-04-03 US US09/937,981 patent/US6476077B1/en not_active Expired - Fee Related
- 2000-04-03 HU HU0200707A patent/HUP0200707A3/hu unknown
- 2000-04-03 IL IL14564500A patent/IL145645A0/xx unknown
- 2000-04-03 SK SK1301-2001A patent/SK13012001A3/sk unknown
- 2000-04-03 PL PL00350568A patent/PL350568A1/xx unknown
- 2000-04-03 KR KR1020017012692A patent/KR20010102580A/ko not_active Application Discontinuation
- 2000-04-03 DE DE60014343T patent/DE60014343T2/de not_active Expired - Fee Related
- 2000-04-03 EP EP00914298A patent/EP1169302B1/fr not_active Expired - Lifetime
- 2000-04-03 TR TR2001/02875T patent/TR200102875T2/xx unknown
- 2000-04-03 AT AT00914298T patent/ATE277893T1/de not_active IP Right Cessation
- 2000-04-03 CN CNA2004100053467A patent/CN1534017A/zh active Pending
- 2000-04-03 AU AU35692/00A patent/AU3569200A/en not_active Abandoned
- 2000-04-03 JP JP2000609386A patent/JP2002541137A/ja active Pending
- 2000-04-03 CN CN00805623A patent/CN1345307A/zh active Pending
-
2001
- 2001-09-26 IS IS6087A patent/IS6087A/is unknown
- 2001-10-04 ZA ZA200108176A patent/ZA200108176B/en unknown
- 2001-10-05 NO NO20014855A patent/NO20014855L/no not_active Application Discontinuation
- 2001-11-01 BG BG106074A patent/BG106074A/xx unknown
-
2002
- 2002-06-26 HK HK02104758.2A patent/HK1044145A1/zh unknown
- 2002-11-01 US US10/286,624 patent/US6586432B2/en not_active Expired - Fee Related
-
2003
- 2003-06-30 US US10/611,052 patent/US6821973B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000059873A1 (fr) | 2000-10-12 |
| NO20014855L (no) | 2001-12-06 |
| ZA200108176B (en) | 2003-01-06 |
| HK1044145A1 (zh) | 2002-10-11 |
| CA2368240A1 (fr) | 2000-10-12 |
| US6586432B2 (en) | 2003-07-01 |
| HUP0200707A2 (en) | 2002-06-29 |
| KR20010102580A (ko) | 2001-11-15 |
| EE200100520A (et) | 2002-12-16 |
| CZ20013574A3 (cs) | 2002-05-15 |
| ATE277893T1 (de) | 2004-10-15 |
| US6821973B2 (en) | 2004-11-23 |
| DE60014343T2 (de) | 2006-03-02 |
| CN1345307A (zh) | 2002-04-17 |
| HUP0200707A3 (en) | 2002-11-28 |
| GB9907571D0 (en) | 1999-05-26 |
| PL350568A1 (en) | 2002-12-16 |
| US6476077B1 (en) | 2002-11-05 |
| IS6087A (is) | 2001-09-26 |
| UA67839C2 (uk) | 2004-07-15 |
| JP2002541137A (ja) | 2002-12-03 |
| US20040106610A1 (en) | 2004-06-03 |
| EP1169302A1 (fr) | 2002-01-09 |
| TR200102875T2 (tr) | 2002-01-21 |
| CN1534017A (zh) | 2004-10-06 |
| IL145645A0 (en) | 2002-06-30 |
| BG106074A (en) | 2002-05-31 |
| BR0009582A (pt) | 2001-12-26 |
| DE60014343D1 (de) | 2004-11-04 |
| AU3569200A (en) | 2000-10-23 |
| US20030092713A1 (en) | 2003-05-15 |
| EP1169302B1 (fr) | 2004-09-29 |
| NO20014855D0 (no) | 2001-10-05 |
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