BG106074A - N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists - Google Patents

N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Info

Publication number
BG106074A
BG106074A BG106074A BG10607401A BG106074A BG 106074 A BG106074 A BG 106074A BG 106074 A BG106074 A BG 106074A BG 10607401 A BG10607401 A BG 10607401A BG 106074 A BG106074 A BG 106074A
Authority
BG
Bulgaria
Prior art keywords
neurokinin
alkyl
hydrogen
optionally substituted
phenyl
Prior art date
Application number
BG106074A
Other languages
Bulgarian (bg)
English (en)
Inventor
Peter Bernstein
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BG106074A publication Critical patent/BG106074A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
BG106074A 1999-04-06 2001-11-01 N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists BG106074A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9907571.5A GB9907571D0 (en) 1999-04-06 1999-04-06 Compounds
PCT/GB2000/001252 WO2000059873A1 (en) 1999-04-06 2000-04-03 N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Publications (1)

Publication Number Publication Date
BG106074A true BG106074A (en) 2002-05-31

Family

ID=10850835

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106074A BG106074A (en) 1999-04-06 2001-11-01 N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists

Country Status (25)

Country Link
US (3) US6476077B1 (xx)
EP (1) EP1169302B1 (xx)
JP (1) JP2002541137A (xx)
KR (1) KR20010102580A (xx)
CN (2) CN1534017A (xx)
AT (1) ATE277893T1 (xx)
AU (1) AU3569200A (xx)
BG (1) BG106074A (xx)
BR (1) BR0009582A (xx)
CA (1) CA2368240A1 (xx)
CZ (1) CZ20013574A3 (xx)
DE (1) DE60014343T2 (xx)
EE (1) EE200100520A (xx)
GB (1) GB9907571D0 (xx)
HK (1) HK1044145A1 (xx)
HU (1) HUP0200707A3 (xx)
IL (1) IL145645A0 (xx)
IS (1) IS6087A (xx)
NO (1) NO20014855L (xx)
PL (1) PL350568A1 (xx)
SK (1) SK13012001A3 (xx)
TR (1) TR200102875T2 (xx)
UA (1) UA67839C2 (xx)
WO (1) WO2000059873A1 (xx)
ZA (1) ZA200108176B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
GB0019008D0 (en) * 2000-08-04 2000-09-27 Astrazeneca Ab Therapeutic compounds
SE0201938D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
KR20050072786A (ko) * 2002-11-05 2005-07-12 아스트라제네카 아베 잠금 덮개를 갖는 안전 용기 및 덮개를 잠그는 방법
US20060058352A1 (en) * 2002-12-20 2006-03-16 Peter Bernstein Piperidine amine compounds and their use
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
MX2017012720A (es) 2015-05-18 2018-02-09 Nerre Therapeutics Ltd Antagonistas duales de receptores de neurocinina-1 (nk-1) / neurocinina-3 (nk-3) para el tratamiento de enfermedades dependientes de hormonas sexuales.
US20210015834A1 (en) 2018-02-26 2021-01-21 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
MA51999B1 (fr) 2018-03-14 2024-02-29 Kandy Therapeutics Ltd Nouvelle formulation pharmaceutique comprenant deux antagonistes recepteurs de nk-1/nk-3.
RU2697414C1 (ru) 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
CA2163995A1 (en) * 1993-06-07 1994-12-22 Malcolm Maccoss Spiro-substituted azacycles as neurokinin antagonists
DK0777659T3 (da) * 1994-08-15 2001-09-03 Merck Sharp & Dohme Morpholinderivater og deres anvendelse som terapeutiske midler
AU5522498A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
WO2002076929A1 (en) * 2001-03-21 2002-10-03 Pharmacopeia, Inc. Aryl and biaryl compounds having mch modulatory activity

Also Published As

Publication number Publication date
WO2000059873A1 (en) 2000-10-12
NO20014855L (no) 2001-12-06
ZA200108176B (en) 2003-01-06
HK1044145A1 (zh) 2002-10-11
CA2368240A1 (en) 2000-10-12
US6586432B2 (en) 2003-07-01
HUP0200707A2 (en) 2002-06-29
KR20010102580A (ko) 2001-11-15
EE200100520A (et) 2002-12-16
CZ20013574A3 (cs) 2002-05-15
ATE277893T1 (de) 2004-10-15
SK13012001A3 (sk) 2002-04-04
US6821973B2 (en) 2004-11-23
DE60014343T2 (de) 2006-03-02
CN1345307A (zh) 2002-04-17
HUP0200707A3 (en) 2002-11-28
GB9907571D0 (en) 1999-05-26
PL350568A1 (en) 2002-12-16
US6476077B1 (en) 2002-11-05
IS6087A (is) 2001-09-26
UA67839C2 (uk) 2004-07-15
JP2002541137A (ja) 2002-12-03
US20040106610A1 (en) 2004-06-03
EP1169302A1 (en) 2002-01-09
TR200102875T2 (tr) 2002-01-21
CN1534017A (zh) 2004-10-06
IL145645A0 (en) 2002-06-30
BR0009582A (pt) 2001-12-26
DE60014343D1 (de) 2004-11-04
AU3569200A (en) 2000-10-23
US20030092713A1 (en) 2003-05-15
EP1169302B1 (en) 2004-09-29
NO20014855D0 (no) 2001-10-05

Similar Documents

Publication Publication Date Title
BG106074A (en) N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists
CY1105899T1 (el) Πυριδινοϋλοπιπepιδινες ως 5-ht1f αγωνιστες
KR20050085991A (en) Compounds exhibiting thrombopoietin receptor agonism
EA200200942A1 (ru) Фармацевтические композиции, содержащие производные 3-аминоазетидина, новые производные и способ их получения
IL176247A0 (en) Cyclopropane compounds and pharmaceutical use thereof
AU2001272476A1 (en) Piperidines for use as orexin receptor antagonists
YU52403A (sh) Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
HUT76476A (en) Morpholine and thiomorpholine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
EA200400981A1 (ru) Новые гетероциклические соединения, активные в качестве ингибиторов бета-лактамаз
MY130907A (en) Piperazine compounds as tachykinins antagonists
RS20060143A (xx) Jedinjenja fenil ili piridil amida kao antagonisti prostaglandina e2
TR200400541T4 (tr) Terapide faydalı tropan türevleri.
TW200510440A (en) Novel compounds
CA2284795A1 (en) Novel pyrimidine derivatives and processes for the preparation thereof
NZ331060A (en) Quinoxalinediones, preparation and pharmaceutical compositions thereof
EA200500087A1 (ru) Производные пиперазина
HUP9903758A2 (hu) Benzoxazinon dopamin D4 receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények
DE60032016D1 (de) Zyklische aminverbindungen als ccr5-rezeptor antagonisten
RS51126B (sr) Postupak za pripremanje mezilata piperazin derivata
MY134226A (en) 1,2-dihydropyrazol-3-ones which control inflammatory cyctokines
RS50085B (sr) Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
IL136510A0 (en) Acylated hetero-alicyclic derivatives and pharmaceutical compositions containing the same
EP1559707A4 (en) SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAID COMPOUNDS AND INTERMEDIATES THEREOF
DK0630893T3 (da) N,N'-disubstitueret amidderivat
MY136065A (en) Prodrugs to nmda receptor ligands