TR200102875T2 - Neurokinin-1 reseptörü antagonistler olarak n-(2-fenil-4-amino-butil)-1-naftamidler. - Google Patents

Neurokinin-1 reseptörü antagonistler olarak n-(2-fenil-4-amino-butil)-1-naftamidler.

Info

Publication number
TR200102875T2
TR200102875T2 TR2001/02875T TR200102875T TR200102875T2 TR 200102875 T2 TR200102875 T2 TR 200102875T2 TR 2001/02875 T TR2001/02875 T TR 2001/02875T TR 200102875 T TR200102875 T TR 200102875T TR 200102875 T2 TR200102875 T2 TR 200102875T2
Authority
TR
Turkey
Prior art keywords
6alkyl
hydrogen
phenyl
naphthomids
neurokinin
Prior art date
Application number
TR2001/02875T
Other languages
English (en)
Inventor
Robert Bernstein Peter
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TR200102875T2 publication Critical patent/TR200102875T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

Abstract

R1R2N-CH2CH2-CHAr1-CH2-NR3-CO-R4 genel formül (I)'e sahip bir bilesikte R1 hidrojen, C1-6alkil, C2-6alkenil, aril, C1-6alkonoil, C1-6 alkoksikarbonil ya da arilkarbonil 'dir; benzer gruplardan herhangi birine vekalet edilebilir; R2 hidrojen ya da C1-6alkil'dir; ya da R1 ve R2 istege bagli olarak vekalet edilen bir morfolino halkasi olusturmak üzere birlestirilmistir; Ar1 halo tarafindan vekalet edilen fenil mono- ya da di-'dir; R3 hidrojen ya da C1-6alkil'dir; R4 istege bagli olarak naft-1-il; ya da onun eczacilikla ilgili kabul edilebilir tuzlari tarafindan vekalet edilendir. Bu bilesikler, iç sebeplerden dogan neuropeptid tasikininlerinin özellikle neurokinin 1 (NK1) reseptörünün farmakolojik hareketlerine düsmanlik ederler.
TR2001/02875T 1999-04-06 2000-04-03 Neurokinin-1 reseptörü antagonistler olarak n-(2-fenil-4-amino-butil)-1-naftamidler. TR200102875T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9907571.5A GB9907571D0 (en) 1999-04-06 1999-04-06 Compounds

Publications (1)

Publication Number Publication Date
TR200102875T2 true TR200102875T2 (tr) 2002-01-21

Family

ID=10850835

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02875T TR200102875T2 (tr) 1999-04-06 2000-04-03 Neurokinin-1 reseptörü antagonistler olarak n-(2-fenil-4-amino-butil)-1-naftamidler.

Country Status (25)

Country Link
US (3) US6476077B1 (tr)
EP (1) EP1169302B1 (tr)
JP (1) JP2002541137A (tr)
KR (1) KR20010102580A (tr)
CN (2) CN1534017A (tr)
AT (1) ATE277893T1 (tr)
AU (1) AU3569200A (tr)
BG (1) BG106074A (tr)
BR (1) BR0009582A (tr)
CA (1) CA2368240A1 (tr)
CZ (1) CZ20013574A3 (tr)
DE (1) DE60014343T2 (tr)
EE (1) EE200100520A (tr)
GB (1) GB9907571D0 (tr)
HK (1) HK1044145A1 (tr)
HU (1) HUP0200707A3 (tr)
IL (1) IL145645A0 (tr)
IS (1) IS6087A (tr)
NO (1) NO20014855L (tr)
PL (1) PL350568A1 (tr)
SK (1) SK13012001A3 (tr)
TR (1) TR200102875T2 (tr)
UA (1) UA67839C2 (tr)
WO (1) WO2000059873A1 (tr)
ZA (1) ZA200108176B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
GB0019008D0 (en) * 2000-08-04 2000-09-27 Astrazeneca Ab Therapeutic compounds
SE0201938D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New process
KR20050072786A (ko) * 2002-11-05 2005-07-12 아스트라제네카 아베 잠금 덮개를 갖는 안전 용기 및 덮개를 잠그는 방법
US20060058352A1 (en) * 2002-12-20 2006-03-16 Peter Bernstein Piperidine amine compounds and their use
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
MX2017012720A (es) 2015-05-18 2018-02-09 Nerre Therapeutics Ltd Antagonistas duales de receptores de neurocinina-1 (nk-1) / neurocinina-3 (nk-3) para el tratamiento de enfermedades dependientes de hormonas sexuales.
US20210015834A1 (en) 2018-02-26 2021-01-21 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
MA51999B1 (fr) 2018-03-14 2024-02-29 Kandy Therapeutics Ltd Nouvelle formulation pharmaceutique comprenant deux antagonistes recepteurs de nk-1/nk-3.
RU2697414C1 (ru) 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
CA2163995A1 (en) * 1993-06-07 1994-12-22 Malcolm Maccoss Spiro-substituted azacycles as neurokinin antagonists
DK0777659T3 (da) * 1994-08-15 2001-09-03 Merck Sharp & Dohme Morpholinderivater og deres anvendelse som terapeutiske midler
AU5522498A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
WO2002076929A1 (en) * 2001-03-21 2002-10-03 Pharmacopeia, Inc. Aryl and biaryl compounds having mch modulatory activity

Also Published As

Publication number Publication date
WO2000059873A1 (en) 2000-10-12
NO20014855L (no) 2001-12-06
ZA200108176B (en) 2003-01-06
HK1044145A1 (zh) 2002-10-11
CA2368240A1 (en) 2000-10-12
US6586432B2 (en) 2003-07-01
HUP0200707A2 (en) 2002-06-29
KR20010102580A (ko) 2001-11-15
EE200100520A (et) 2002-12-16
CZ20013574A3 (cs) 2002-05-15
ATE277893T1 (de) 2004-10-15
SK13012001A3 (sk) 2002-04-04
US6821973B2 (en) 2004-11-23
DE60014343T2 (de) 2006-03-02
CN1345307A (zh) 2002-04-17
HUP0200707A3 (en) 2002-11-28
GB9907571D0 (en) 1999-05-26
PL350568A1 (en) 2002-12-16
US6476077B1 (en) 2002-11-05
IS6087A (is) 2001-09-26
UA67839C2 (uk) 2004-07-15
JP2002541137A (ja) 2002-12-03
US20040106610A1 (en) 2004-06-03
EP1169302A1 (en) 2002-01-09
CN1534017A (zh) 2004-10-06
IL145645A0 (en) 2002-06-30
BG106074A (en) 2002-05-31
BR0009582A (pt) 2001-12-26
DE60014343D1 (de) 2004-11-04
AU3569200A (en) 2000-10-23
US20030092713A1 (en) 2003-05-15
EP1169302B1 (en) 2004-09-29
NO20014855D0 (no) 2001-10-05

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